Stopping peg intron therapy

Common Questions and Answers about Stopping peg intron therapy


Avatar n tn Can you speak with your doctor about possibly switching to the other interferon, Pegasys? I understand that Peg Intron can produce much more severe side effects at the beginning which I why I chose Pegasys. I too am doing only 6 months and am very grateful for that. If you've hung around here for awhile you will be very humbled by others' experiences. There are folks here who have treated 4 to 5 or more times. About alternatives, I learned I had this 14 years ago.
163305 tn?1333672171 I have heard that the sx for peg-intron are worse than pegasys. There is a thread from last week discussing this very topic. You might check the archives for a quick answer.
314554 tn?1337457719 I realize this is a frequently addressed topic – but I am trying to get this straight in my mind; so, here goes: Given: 1) Due to it's longer and branched-chain PEG, Pegasys has a half-life ("terminal elimination") of 50-80 hours. 2) Whereas, due to it's shorter and linear-chain PEG, Peg Intron has a half-life of 30-50 hours. (Note that NPIA or non-pegylated interferon alfa has a half-life of only 3-5 hours.
201379 tn?1319994931 I've failed two rounds of IFN+RIBA (one with PEG-IFN). My doc suggested going on maintenance therapy with PEG-IFN; 90 ug once per week, no RIBA. She said three years duration. Anyone out there have experience with this treatment that could enlighten me regarding sides, skin problems, hair loss, etc? I worked with both treatment rounds but felt like hell.
181564 tn?1189759424 It's a pity you don't have early info on your response, but the majority of genotype 2's do become UND at week 4, and about 80% can treat for 12 weeks of Peg-Intron or 16 of Pegasys and still make it. I bet you'll be one of them. As for me, I go for my 4 month blood tests (that's 4 months after stopping) next week and will know more after my doc appt. on 7/27. I'll keep you posted. To your health....
188500 tn?1207368551 It may only confirm what you already know. § PEG-Intron is the Same Drug as Interferon Only Worse § PEG-Intron is NOT Safe § PEG-Intron is NOT Effective You need only read one paragraph into the study to learn that PEG-Intron is the same drug as Interferon, only modified to stay in your system longer (Thereby killing you more consistently) ."PEG-lntronTM, peg-interferon alfa-2b, is a covalent conjugate of recombinant interferon alfa-2b with monomethoxy polyethylene glycol product.
Avatar n tn Given your low pre-tx viral load and minimal liver damage (stage 1), you should also discuss with your doctor the option of treating only 12 or 16 weeks (12 for Peg Intron, 16 for Pegasys)if you are non-detectible via a very sensitive blood test by week 4. Studies suggest that those with low pre-tx viral loads who are non-detec at week 4 have comparable success rates with those who treat 24 weeks. My guess is this is what your doctor has in mind with the early 3 week test, but do ask him.
Avatar f tn Good for you! Are you on peg-intron or pegasys. the studies for peg-intron were for 12 weeks and I though I'd do an extra 8 to increase my chances. I know I would have increased my chances more by 24 but it wasn't just the HGB. It was the tongue that felt like it was transplanted from someone twice my size for my mouth, and boiled before they put it in! It's the constant itching, that I thought was resolving but kept me up for hours again last night.
Avatar f tn (12 weeks for Peg Intron, 16 weeks for Pegasys) A later and larger study suggested that 24 weeks showed better results than the shorter courses, but I believe the shorter course group still had an SVR rate of around 80 per cent. The study therefore concluded that while the optium tx length for geno 2's and 3's was 24 weeks -- the shorter course is a very good option for those experiencing significant side effects -- which definitely would be someone like you.
Avatar m tn well to make a long story short after fighting for a month and finaly threating to sue medco health finaly sent the riba. they had sent the peg-intron 3 weeks ago. so i'm trying to see the hep np at the university and start treatments on friday. will be at least 48 weeks and dr. will let me know if we need to extend near the end. going to be a long haul for me white cell count is 1.
Avatar n tn I had the same thing happen on Pegasys. I ended up going back over to Peg-Intron and I've had much better results with that, even with the increased side effects.
Avatar n tn My doc will now be running the big head-to-head study pitting Peg-Intron against Pegasys. I do believe that Peg-Intron is more difficult, and more toxic, but all I care about is cure rate, and effectiveness. I am a big believer in the fast decline curve being the best indicator of success, and adjusting dosages to get the adequate clearance rate. Sorry for the long winded reply, but I hope I have answered your questions.
Avatar m tn Eight years ago when I took the SOC I was told that Pegasys, which was relatively new then was better than the Peg intron which had been available for some time. I was also told by my doctor who was treating a large number of patients at his clinic that he had observed that the Pegasys was more easily tolerated than the other drug.
Avatar n tn I treated with Intron A/Ribaviron (Shering's precurser to Peg-Intron) and lasted 2 months before having to quit due to severe side effects. I finished 48/48 of Pegasys 2 years ago. Although it was no walk in the park, the side effects were much more tolerable. I was able to work and go on with my life while on tx. I am 2 years SVR 1A. Everyone's body chemistry is different. There are slight chemical differences between the two interferons.
Avatar n tn Latest VL showed 2,900,000? Therapy was not the easy and I was off work for 6 mths. After stopping therapy on 8/22, I felt extremely better. Energy level bounced back incredibly. I won't let myself even think about another round of interferon at this time. I have spoken to a retired well respected physician & he is recommending that I repair the liver as much as possible before considering another form of therapy.
Avatar n tn It sounds to me like she did the non-pegylated form of interferon first, and then tried again with Peg-Intron and it still hasn't worked. I doubt she did infergen the first time around, that torture is usally reserved for non-responders or relapsers.
157966 tn?1218228940 I have done infergen as a last result. It was tougher for me than peg-intron, pegasys. It is used with Riba. I started with 3 shots per wk., then upped to every day for 52 wks. I cleared for 6 straight mths., and relapsed 1 mth. after stopping in Aug. This doesn't mean that this will happen to you or others. If I can be of any further help, just let me know.
2030686 tn?1351692148 From the two trials cited in Can-do's link: Using weight dosed Peg-Intron and weight dosed riba - "In an analysis of all RVR patients treated per protocol, 91% of those who received 14 weeks of therapy achieved SVR, compared with 95% of those treated for 24 weeks. The difference of 4% fell well within the pre-determined 10% margin needed to show inferiority, allowing the researchers to conclude that 14 week treatment was non-inferior to 24 weeks..........
Avatar n tn While on treatment I did clear the virus and my blood work normalized. After finishing Treatment the virus came back. I also was on Peg-Intron therapy when it was first approved, I was able to only complete 2 months of treatment before it was stopped because of low white counts. My DR said we probably should have waited longer between treatments, to give my body time to recuperate from the first treatment, this was in feb-2002. I will try Pegasys or Peg-Intron next spring.
Avatar m tn In many but not all cases these disorders resolve after stopping PEG-INTRON therapy. Ribavirin causes hemolytic anemia. Anemia associated with REBETOL therapy may exacerbate cardiac disease that has led to fatal and nonfatal myocardial infarctions. Patients with a history of significant or unstable cardiac disease should not be treated with REBETOL. It is advised that complete blood counts (CBC) be obtained at baseline and at weeks 2 and 4 of therapy or more frequently if clinically indicated.
Avatar n tn switch to peg intron. peg intron has a different mode of action. u might also want to try increased dosages of peg intron...higher than normal dosage that is. but of course discuss thsi with your doctor first.
Avatar n tn Short (14 Weeks) Combination Treatment with PEG-Intron Plus Ribavirin Produces a High Sustained Response Rate in Patients with HCV Genotype 2/3 Abstract Summary The objective of this multicenter Norwegian trial is to determine the virological response rate after 14 weeks of combination treatment with PEG-Intron (peginterferon alfa-2b) and ribavirin in patients with hepatitis C virus (HCV) genotype 2/3 who experience early HCV clearance.
Avatar n tn I have Kaiser in Northern California (Sacramento) and I pay $20 for name brand name meds (Incivek, Peg-Intron) and $10 for generic (ribavirin) and got 4 weeks at a time for the triple drugs. I am also on the brand name drugs Promacta (for low platelets - 75-mg - 30 day supply) and Neupogen (for low WBC - 10 week supply). Kaiser does have many different levels of coverage and I believe mine to be fairly low cost.
Avatar m tn I asked about the Pen thing because I've never used them. When I was the Peg-Intron in the past, I never used the pen, I always used the other method of Peg-Intron (a vial or Prefilled syringe - don't remember which it was). It's been a few years since the Peg-Intron for me. One time, I had this Pen-like device for another medication - not an interferon drug and I did not do well with it.
Avatar n tn After 9 weeks of this treatment (peg intron & ribovirian) I have to stop. I cannot take the sides anymore. I am a 1a, and am raging so bad that I have told all of the people that I love to get out of my life. I have zero quality of life right now and by continuing on with tx I will alienate everyone in my life....I asked the doc if I could just stop the ribavirian...he is not in favor of doing that. This is the hardest decision I have made in my life.....
Avatar m tn Peg, the molecules are different and so is the dosing scheme with Peg Intron dosed by weight and Pegasys with a one dose for all weight scheme. You will also find advocates among leading doctors/reseachers for both in private conversations although the ones I've spoken to -- advocates on both sides -- admit their conclusions are somewhat anecdotal. For example, one of my consultants said that he found the vl response identical, but fewer relapses with Peg Intron.
Avatar m tn I had previous tx with peg-intron a few years ago and had a svr at 4 weeks but after 48 weeks stopped treatment and relapsed. I know we are not Dr.s here but is there any data that suggests that 48 weeks gives it a better chance if I become indectable at 4 weeks with the triple tx? PS my geno-type is 1a and viral load is 12 million. I really dont want to do 48 weeks but if there is a better chance with 48 weeks would want to consider that as an option.
Avatar n tn I am sorry about your news, but listen to this: My friend 1a was on Peg-Intron for 16 weeks and did not clear but switched over to Pegasys and cleared at 26 weeks. She has to continue on tx for 62 weeks, but she's doing it and hoping for the best.
Avatar m tn if it has to be Pegasys if one could go with Peg-Intron. I responded better myself to Peg-Intron than Pegasys. Pegasys was a bust, a big waste of time, for me. And in fact, my viral load went up and my LFT's went up. Just curious on that.
Avatar f tn 1996 with feritin depletion followed by interferon. 1998 with riba/interferon 2001 with peg - intron 2004 with pegasys Now in Prove 3 Vertex. I have been stage 3 since 1992. I had a gallstone attack in 1992 while I was on interferon and my ast/alt went to 900/1100. favorite movies: water, Cinema Paradiso, The Namesake.