This can lead to decreased blood levels of thyroid hormone and cause symptoms including fatigue, weakness, weight gain
, intolerance to cold, hair and skin changes, constipation, irritability, memory loss and menstrual changes. SO if you are taking any of the other medications mentioned above except the Nexium space them about 4 hours from the Synthroid. I recommend asking your Dr, for name brand Synthroid instead of generic. I find I had your mentioned symptoms with generic Synthroid.