for your situation entecavir is the most suitable drug, low kidneys damage if any and low resistance but if you use lamivudine entecavir cannot be used because lamivudine makes resistance mutations to enecavir too
i think you d best work to improve your kidneys function by supplements as decribed above and look for coverage for hbv drugs which are only tenofovir, entecavir or peginterferon.
I understood what you explained me about it. Should I check blood test on HBV/DNA/PCR or HBsAg (Quantity) ? If resistance of lamivudine, what name of the drug will be changed?
- If the HBsAb become Positive level, my liver working well or not?
- What drugs can't I use? (Avoid hepatotoxic) when I got diarrhea - Headache or fever.
My doctor has asked me to take lamivudine 100 mg for 6 months or until hbv dna becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
Maybe Entecavir is more potent on HBe + and Tenofovir in HBe-, but if you have Lamivudine resistance already the chance to become Entecavir resistance incerease, so maybe Tenofovir will be a good option, or maybe a combo Tenofovir / Entecavir
I am not a doctor but i can tell you lamivudine is the worst drug for hbv and just make damage.
Lamivudine is outdated and ur virus will multiply anyway someday due to resistance to it so best is change to tenofovir and also change ur doctor who even don't know in today's time lamivudine is not used.
My doctor has asked me to take lamivudine 100 mg for 6 months or until it becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
After treatment HBV, I took lamivudine 100 mg/day DNA/HBV is negative since May 2008. Successive (check blood DNA HBV Every 3 months).
Now after I stopped using lamivudine 2 months
-DNA/HBV: 280,000 Copies = 2,8 x 5log10.
-SGOT : 140 ui
-SGPT : 300 ui
Should I take tenofovir 0,5 mg alone or plus lamivudine 100 mg ?
The antiviral lamivudine (Epivir-HBV) has fallen out of favor as an antiviral treatment for hepatitis B because it causes drug resistance.
However, a study reported in the Digestive Diseases and Sciences found the antiviral was effective when administered in high doses in patients with cirrhosis.
so if an HBV-naive adult becomes infected with a lamivudine mutant and recovers, will he still get infected with the "original" versions of HBV?
regarding prophylaxis stefano, if one is tested and is negative for HBSAG in at least 3 occasions and weeks apart for each test and injected with a recombinant HBV vaccine, will that be a good sign?
The available data suggest that telbivudine is slightly more effective than lamivudine in suppressing HBV DNA in patients who are HBeAg positive but the benefit does not appear to translate into a clinically important advantage for HBeAg seroconversion or histologic improvement. Regards.
HBV carriers do not typically require medication such as lamivudine, which itself can sometimes cause virological resistance and could explain the elevated liver tests. their elevation is not related to working out. You should check your HBV-DNA level.
Objectives
The aim of this study was to characterise a novel HBV pattern which shows resistance to lamivudine, adefovir dipivoxil and entecavir using in vitro phenoyping assay.
Study design
A male 36 years old patient diagnosed with anti HBe-positive chronic hepatitis B (CHB) had received lamivudine treatment for 7 years following an initial unsuccessfull interferon treatment. The therapy had been switched to adefovir and then to entecavir when breakthrough occcured during each treatment.
you can blame the doctor for her situation lamivudine can t be used on hbv and is proposed for a ban, entecavir can t also be used once lamivudine is used because they share same development of resistance and then entecavir resistance is difficult to manage, change butcher immediately a doctor like that can only work as a butcher and get your mother tenofovir plus entecavir, resistance to a nuc can be deadly for her so the combo must be used here
i hope you dont have financial limits because a
So best not to use Lamivudine as it has very high drug resistance rate. Usually Lamivudine has very few side effects, so it is unlikely to cause all the problems you are experiencing.
The mechanism for resistance is differ from antiviral to antiviral. For example, Lamivudine resistance is more on and off. Adefovir is more gradual. Unless you research this area, it's hard to know what exactly is happening. But we do know all antivirals are at risk for resistance over time. And since you are 40 with early cirrohsis, you need the antiviral to stay working for another 30 years or so without resistance, that is a tough goal.
look for a liver specialist that doctor doesn t know hbv and doesn t know hbv drugs, antivirals have no effect on hbv virus and are used only to stop liver damage so you have to take them from decades to all life
tenofovir is the only 100% safe drug for hbv since there are no known mutations or resistance to it and of course it is the most potent on hbv, it may take about 17years to clear hbv definitively
no these drugs make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now
sorry a big mistake i did here, this drug lamivudine make untreatable virus mutants, this was a failure on hiv and hbv and should never be used now.
What does that mean???
--You have HBV with UND HBVDNA.
Are you taking the conventional, Western-medicine route or some other route?
If the former, according to AASLD Hep-B Guideline 2009 Update,
If you are HBeAg+, HBV DNA (PCR) >20,000 IU/mL ALT 40 years, ALT persistently high normal-2x ULN, or with family history of HCC. Consider treatment if HBV DNA >20,000 IU/mL and biopsy shows moderate/severe inflammation or significant fibrosis.
She has also been a patient of anemia.For the last 1.5 years she has been on lamivudine 100 after her hbv dna crossed 86 lacs. iu/ml in 2012.So far everything has been fine,the liver enzyme levels(AST/ALT/ALP) have nearly normalized,platelet count has increased.But one day ago she underwent a blood test and found that:Sgpt=206,Sgot=131,Alk. phosphatase=88,serum bilirubin total=0.9...While alk.
ADV not preferred due to weak antiviral activity and high risk of resistance after 1st year. HBV DNA6 months; 2. Serum HBV DNA >20,000 IU/mL (105copies/mL), lower values 2,000- 20,000 IU/mL (104-105 copies/mL) are often seen in HBeAg-negative chronic hepatitis B; 3. Persistent or intermittent elevation in ALT/AST levels; 4. Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation.
Inactive HBsAg carrier state: 1. HBsAg-positive >6 months; 2. HBeAg-, anti-HBe+; 3.
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