My doctor has asked me to take lamivudine 100 mg for 6 months or until hbv dna becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
I understood what you explained me about it. Should I check blood test on HBV/DNA/PCR or HBsAg (Quantity) ? If resistance of lamivudine, what name of the drug will be changed?
- If the HBsAb become Positive level, my liver working well or not?
- What drugs can't I use? (Avoid hepatotoxic) when I got diarrhea - Headache or fever.
I am not a doctor but i can tell you lamivudine is the worst drug for hbv and just make damage.
After treatment HBV, I took lamivudine 100 mg/day DNA/HBV is negative since May 2008. Successive (check blood DNA HBV Every 3 months).
Now after I stopped using lamivudine 2 months
-DNA/HBV: 280,000 Copies = 2,8 x 5log10.
-SGOT : 140 ui
-SGPT : 300 ui
Should I take tenofovir 0,5 mg alone or plus lamivudine 100 mg ?
My doctor has asked me to take lamivudine 100 mg for 6 months or until it becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
lamivudine is not a hbv drug anymore and it is useless on hbv so you have just wasted money, all antivirals are useless on hbv infection, they can only lower replication to lower liver damage but most hbv carriers have even no liver damage so look for an expert liver specialist to guide you or check all forum posts
the only drugs to use safely to block liver damage are: interferon, tenofovir, entecavir.
HBV DNA clearance was assessed using assays with different sensitivities to detect HBV DNA. Adefovir and lamivudine increased HBV DNA clearance at end of treatment versus placebo. Entecavir increased clearance versus lamivudine with inconsistent effect size. Lamivudine was less effective than adefovir in lamivudine-resistant patients and less effective than telbivudine in HBeAg-positive patients.
"Entecavir should not be used in patients with previous lamivudine resistance, yet it may still be an option in lamivudine-experienced patients in case lamivudine resistance never developed," - http://www.hivandhepatitis.com/hep_b/news/2010/0402_2010_a.
1. I am HBV carrier, and I am also under treatment with taking lamivudine 100mg daily. Will this impact the result? Will lamivudine/HBV virus cause false negative?
2. Because I am taking lamivudine daily, will this cause the delay of seroconversion. I think the test was done about 18 months after events that I thought maybe risky.
3. My test is Combo TypeI/II antibody and p24 antigen QUAL CMIA. Is it reliable?
4. My HBV DNA level is sometimes undetectable, but sometime a few hundreds.
About one year ago when I conducted Hepatitis B profile, I had NON RELICATIVE INFECTION but about one year on lamivudine I am now REPLICATIVE. Please what does this suggest? I am planning to stop taking lamivudine because it gives me so much side effect ranging from stomach discomforts and back pains and general weakness. The doctor I met this time related all these complaints to lamivudine.
interferon+tenofovir+alinia+lamivudine (interferon+alinia lower hbsag to zero and this means hbv clerance, tenofovir+lamivudine will keeep hbvdna undetactable), you should clear hbv in 1-2 years
hbs ag quantitative 6535 COI
this is needed in iu/ml, no other unit is useful
hbvdna must stay undetactable
lamivudine is NOT an hbv drug anymore since years it makes virus mutations which worsen the infection.
Lamivudine will not cure you or clear HBV. It also has poor resistance profile. You need to consult an expert. Not just any doctor.
Your low DNA should not prevent you from working, unless your employer is limited or biased on HBV.
Best.
She has also been a patient of anemia.For the last 1.5 years she has been on lamivudine 100 after her hbv dna crossed 86 lacs. iu/ml in 2012.So far everything has been fine,the liver enzyme levels(AST/ALT/ALP) have nearly normalized,platelet count has increased.But one day ago she underwent a blood test and found that:Sgpt=206,Sgot=131,Alk. phosphatase=88,serum bilirubin total=0.9...While alk.
so if an HBV-naive adult becomes infected with a lamivudine mutant and recovers, will he still get infected with the "original" versions of HBV?
regarding prophylaxis stefano, if one is tested and is negative for HBSAG in at least 3 occasions and weeks apart for each test and injected with a recombinant HBV vaccine, will that be a good sign?
1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey.
CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside naïve.
The antiviral lamivudine (Epivir-HBV) has fallen out of favor as an antiviral treatment for hepatitis B because it causes drug resistance.
However, a study reported in the Digestive Diseases and Sciences found the antiviral was effective when administered in high doses in patients with cirrhosis.
Schiano,one more thing I want to ask you is that should I stop taking lamivudine 100 as long as my hbv dna is -ve or continue with it?Actually I consulted two doctors but none of them could clearly specify whether I should stop treatment or continue with it.Since you have indicated mild inflammation in my liver,do i need to take medicines to cure my liver?
first of all lamivudine is a wrong choice because it is not used anymore on hbv and even for fulminant hbv tenofovir or entecavir are the best choice because they suppress hbv immediately while lam is too weak and takes too long to make hbvdna und, also rates of patients without death is much higher for tenofovir or entecavir than lam
if you are having liver decompensation making hbvdna und, ast-alt normal as soon as possible and then use of immune suppressive cortison is the way to go since yo
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