who is the crazy docotor who prescribed lamivudine/epivir, add tenofovir as soon as possible, lamivudine don t cure hbv and makes hbv mutations which can be untreatable and can make liver cancer even if hbvdna undetactable
do add tenofovir as soon as possible, you have just worsen your condition with lam, it is not indicated for hbv anymore, only tenofovir (viread) entecavir (baraclude) interferon are
to know if you are clearing you need hbsag quantitative in iu/ml and to know if you are saf
When you first treated, Epivir (Lamivudine) was almost exclusively used as Hepsera was just approved back then in 2002. It's fair to conclude the most doctors were still feeling their way on treatment sinc not much information was available, especially on the consequences of Lamivudine resistance. Even today, many doctors are still feeling their way. You could only imagine what it was like 5 years ago.
Epivir=Lamivudine, said to be very safe for husband and wife who wish to have children. But do you have to choose Lamivudine as first-line treatment with its high resistance profile?
The antiviral lamivudine (Epivir-HBV) has fallen out of favor as an antiviral treatment for hepatitis B because it causes drug resistance.
However, a study reported in the Digestive Diseases and Sciences found the antiviral was effective when administered in high doses in patients with cirrhosis.
When to Start, When to Stop, and When to Change Therapy," Keeffe, E.B. March 5, 2008.
Just wondering, I had a liver transplant three years ago. They said the donor had a HBV antibody but they did not detect HBV. I decided to go ahead and go through with the the transplant. The doctors said 1 to 2% chance of HBV appearing. I had been vaccinated (the three shots) about 15 years earlier and so I have HBV antibodies.
After the transplant my doctors said I should go ahead and take Epivir just in case they'd missed something.
I was wondering given the following conditions - 1) HBV is UND (<357/IU) 2) On Epivir for the last several years because after some surgery the doctors thought it was possible I had been exposed to HBV or got some tainted blood 3) previously had the HBV vaccine 15 years ago. 4) No signs of HBV.
Hi, if the viral load is greater than 20,000 IU/mL and HBeAg is negative then Interferon-alfa (Roferon A, Intron A), pegylated interferon-alfa (Pegasys, Peg-Intron), lamivudine (Epivir-HBV), adefovir (Hepsera), entecavir (Baraclude), tenofovir (Viread) or telbivudine (Tyzeka) may be used as initial therapy. There are standard protocols for therapy of hepatitis B infections, so you can clarify your doubts with your treating doctor. Regards.
I treated with hep b 14 years ago for 1.5 years with epivir and got hbv e antibodies and afterwards, I stop epivir and every 6 months I check my liver function and alt and ast are persistently normal. I started to check hbv dna 6 months ago as new guidelines come out. Hbv dna at six month was 5000 iu/ml and last week I checked it was 8000 iu/ml. Again both times my alt and ast are normal. As a matter of fact they are in low side of normal.
Hepatitis B virus (HBV) rebounded in nearly 80% of people treated with fully or partially suppressive antiviral therapy using adefovir (Hepsera), entecavir (Baraclude), lamivudine (Epivir), or tenofovir (Viread), indicating that long-term therapy is usually needed to control the virus, researchers reported at IDWeek 2014 last month in Philadelphia.
Hepatitis B may be treated with a number of approved nucleoside/nucleotide analog antiviral drugs.
My doctor has asked me to take lamivudine 100 mg for 6 months or until hbv dna becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
In June 2008 I was tested positive to hepatitis B and was on EPIVIR Lamivudine 150mg for six months and I quit taking meds and took my mind of meds but to stay healthy by eating and drinking healthy.
Fast forward to June 2014, I went ahead for a medical checkup and below is the result:
HEPATITIS B: POSITIVE
HCV: NON-REACTIVE
HEPATITIS B SURFACE ANTIBODY (Anti-HBs), SERUM (CMIA): 0.00
S.G.O.T.(AST) is 39
S.G.P.T.(ALT) is 21
Alk Phosphate is 162.3
Total Bilirubin is 0.8
Direct Bilirubin is 0.
Antivirals such as Entecavir (Baraclude), Telbivudine (Tyzeka), Tenofovir, Adefovir (Hepsera), lamivudine (Epivir-HBV) have less upfront side effects but their long term consequences hurt patients even more: possible lifetime dependency, resistence issue, cost burden, toxicity, possible link to neuropathy, nephropathy and cancer, etc. With all these consequences the cure rate is a miserable below 1%! That is why I choose to manage my chronic HBV with foods, herbs and adjusted life style.
I understood what you explained me about it. Should I check blood test on HBV/DNA/PCR or HBsAg (Quantity) ? If resistance of lamivudine, what name of the drug will be changed?
- If the HBsAb become Positive level, my liver working well or not?
- What drugs can't I use? (Avoid hepatotoxic) when I got diarrhea - Headache or fever.
I am not a doctor but i can tell you lamivudine is the worst drug for hbv and just make damage.
After treatment HBV, I took lamivudine 100 mg/day DNA/HBV is negative since May 2008. Successive (check blood DNA HBV Every 3 months).
Now after I stopped using lamivudine 2 months
-DNA/HBV: 280,000 Copies = 2,8 x 5log10.
-SGOT : 140 ui
-SGPT : 300 ui
Should I take tenofovir 0,5 mg alone or plus lamivudine 100 mg ?
My doctor has asked me to take lamivudine 100 mg for 6 months or until it becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
lamivudine is not a hbv drug anymore and it is useless on hbv so you have just wasted money, all antivirals are useless on hbv infection, they can only lower replication to lower liver damage but most hbv carriers have even no liver damage so look for an expert liver specialist to guide you or check all forum posts
the only drugs to use safely to block liver damage are: interferon, tenofovir, entecavir.
HBV DNA clearance was assessed using assays with different sensitivities to detect HBV DNA. Adefovir and lamivudine increased HBV DNA clearance at end of treatment versus placebo. Entecavir increased clearance versus lamivudine with inconsistent effect size. Lamivudine was less effective than adefovir in lamivudine-resistant patients and less effective than telbivudine in HBeAg-positive patients.
"Entecavir should not be used in patients with previous lamivudine resistance, yet it may still be an option in lamivudine-experienced patients in case lamivudine resistance never developed," - http://www.hivandhepatitis.com/hep_b/news/2010/0402_2010_a.
1. I am HBV carrier, and I am also under treatment with taking lamivudine 100mg daily. Will this impact the result? Will lamivudine/HBV virus cause false negative?
2. Because I am taking lamivudine daily, will this cause the delay of seroconversion. I think the test was done about 18 months after events that I thought maybe risky.
3. My test is Combo TypeI/II antibody and p24 antigen QUAL CMIA. Is it reliable?
4. My HBV DNA level is sometimes undetectable, but sometime a few hundreds.
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