Lamivudine is outdated and ur virus will multiply anyway someday due to resistance to it so best is change to tenofovir and also change ur doctor who even don't know in today's time lamivudine is not used.
for your situation entecavir is the most suitable drug, low kidneys damage if any and low resistance but if you use lamivudine entecavir cannot be used because lamivudine makes resistance mutations to enecavir too
i think you d best work to improve your kidneys function by supplements as decribed above and look for coverage for hbv drugs which are only tenofovir, entecavir or peginterferon.
You treated with Lamivudine alone and developed resistance. Then your doctor took you off Lamivudine and gave you Hepsera (Adefovir). If so it's a terrrible treatment strategy.
If you just taking Adefovir now, you should absolutely go on the trial. Either option is better for you than Adefovir at this point.
If you develop resistance to Adefovir as well, you will be at higher risk for resistance to other HepB antivirals.
Since there is no known testing for Men, what is your recommendation (if not about resistance) for the husband, Lamivudine or Entecavir, in terms of having safe children?
I will make sure to ask my doctor on my next visit. But, would love to hear from other professional for 2nd/3rd opinion. thanks.
it is possible that you have developed resistance and may need to check a viral level and if (+) be switched to another medication. Resistance is very common with lamivudine use. a CT scan or U/s should also be checked.
Sequencing for lamivudine resistant mutants in two cases where serum was available failed to show evidence of mutations associated with lamivudine resistance. CONCLUSION: Hepatitis B virus reactivation, leading to decompensation and death, are possible complications of treatment withdrawal and patients should be monitored closely if therapy is ceased.
tenofovir (most potent, no resistance), entecavir (resistance very high on lamivudine users so it cannot be used if not naive to treatment), peginterferon
many years of tenofovir (3-6years) and then peginterferon add on are showing 50% cure of hbv by 1 year of combo, al low hbsag less than 1000iu/ml is a good time to add on peginterferon to clear definitively in more cases
you can blame the doctor for her situation lamivudine can t be used on hbv and is proposed for a ban, entecavir can t also be used once lamivudine is used because they share same development of resistance and then entecavir resistance is difficult to manage, change butcher immediately a doctor like that can only work as a butcher and get your mother tenofovir plus entecavir, resistance to a nuc can be deadly for her so the combo must be used here
i hope you dont have financial limits because a
Maybe Entecavir is more potent on HBe + and Tenofovir in HBe-, but if you have Lamivudine resistance already the chance to become Entecavir resistance incerease, so maybe Tenofovir will be a good option, or maybe a combo Tenofovir / Entecavir
Lemividine has a serious resistance Don't use. best drug r entecavir or tenofovir worldwide change your dr immediately and consult good dr who is specialist in Hbv.
I am a 26 year old male having hbsag and hbeag=+ve,hbv dna =1070 iu/ml(Taqman) but my LFT results are normal(sgpt=37,sgot=33).My doctor has asked me to take lamivudine 100 mg for 6 months or until it becomes -ve.My mom is taking lamivudine for the last 7 months after her hbv dna crossed 8 lacs iu/ml.Probably I have been infected from my birth.Is it possible for both of us to completely cure Hep. B after taking lamivudine.
HBV carriers do not typically require medication such as lamivudine, which itself can sometimes cause virological resistance and could explain the elevated liver tests. their elevation is not related to working out. You should check your HBV-DNA level.
Objectives
The aim of this study was to characterise a novel HBV pattern which shows resistance to lamivudine, adefovir dipivoxil and entecavir using in vitro phenoyping assay.
Study design
A male 36 years old patient diagnosed with anti HBe-positive chronic hepatitis B (CHB) had received lamivudine treatment for 7 years following an initial unsuccessfull interferon treatment. The therapy had been switched to adefovir and then to entecavir when breakthrough occcured during each treatment.
Unfortunately, in 2002 when your wife first started with Lamivudine, antiviral treatment was still somewhat new and probably didn't fully understand what resistance means (and sadly some still don't). And in 2002, Adefovir was approved for treating HepB. Lamivudine has has a poor resistance profile. We know that now but can't turn back the clock.
Now, I am NOT a doctor. But I read that Telbivudine is okay to use during a pregnancy. So ask your wife doctor about that option.
So best not to use Lamivudine as it has very high drug resistance rate. Usually Lamivudine has very few side effects, so it is unlikely to cause all the problems you are experiencing.
I have been on lamivudine and adefovir for 4 years (after resistance to 6 years of lamivudine).I have developed renal tubulopathy because of the toxic effect of adefovir.my DNA is undetectable ALAT ASAT normal.My doctor advised me to take lamivudine every day and adefovir just one pill every 48 hours.He also thinks that he might put me on Baraclude(entecavir) monotherapy.What do you think? Please advise me .Thanks very much for your help.
Monotherapy using lamivudine has the longest history of use and shows highest rate of resistance. A 2003 study of 998 patients showed 65% lamivudine-resistance mutations in 5 years. Lamivudine should no longer be used as monotherapy.
2. Monotherapy using adefovir has 29% mutation probability in 240 weeks, according to a 2006 study of 125 patients.
3. Entecavir is 100-fold more potent than lamivudine or adefovir.
the answer is yes for both
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