Many strains are resistant to antibiotics, especially tetracycline
resistance. This means
doxycycline, a commonly prescribed drug, will often fail in treatment. Resistance rates of 50% have been reported for ureaplasma and doxycycline. M hominis is resistant to erythromycin, azithromycin, and clarithromycin. Levofloxacin, another common drug, also has been shown to have a high failure rate for M genitalium.