Vitamin d receptor
Common Questions and Answers about Vitamin d receptor
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s Murdoch School of Biological Medicine and Biotechnology explains that increased ingestion of vitamin D affects more than bone health. The Vitamin D receptor, a protein on cells that reacts with vitamin D molecules is involved in the repression or transcription of hundreds of genes associated with diseases ranging from cancers to multiple sclerosis. The Vitamin D receptor also regulates innate immunity particularly the body?s natural antimicrobial peptides.
you need to increase vitamin d dose, having a high pth while also having high/normal vitamin d means vitamin d receptors are blocked.
this happens for almost all chronic diseases especially hbv carriers but can be also due to the vitamin d receptor genotype, weaker vit d receptor genotypes are linked to weaker immune system and various diseases and hbv chronicity as well.
The insights are based on molecular research showing that 25-D inactivates rather than activates its native receptor - the Vitamin D nuclear receptor or VDR. Once associated solely with calcium metabolism, the VDR is now known to transcribe at least 913 genes and largely control the innate immune response by expressing the bulk of the body's antimicrobial peptides, natural antimicrobials that target bacteria.
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researchers have found that vitamin d needs oleic acids to bound to gcmaf which bounds to vdr receptor on immune cells influencing trl7 the most
i have no idea if this form of vit d can be more active on hbv than normal vit d3, too early to say, but i think it would be useful if some members use this
of course we need a member with vit d deficency so it is easier to see if there is any difference with normal vit d3, since latest human trials showing inactive carriers have high vit
If you experience a worsening of symptoms when starting thyroid medication, adrenal insufficiency needs to be ruled out. Thyroid hormone preparations are generally contraindicated (a reason to withhold a medical treatment) in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency.
ve learned that excessive vitamin A interferes with the effectiveness of Vitamin D since they can compete for some of the same receptor sites. I take a pretty good dose of fish oil every day and am wondering if it has any vitamin A in it. I wouldn't want to take anymore vitamin A than what is already in my multivitamin.
I know cod liver oil has vitamin A and D, but what about regular fish oil from things like anchovy, mackerel and sardines?
Patients with cancer are at high risk for vitamin D deficiency. Sensible sun exposure, vitamin D fortification and vitamin D supplementation should be encouraged to improve the vitamin D status of children and adults not only for bone health but for reducing risk of developing and dying of cancer.
The goal is to achieve a blood level of 25-hydroxyvitamin D of 40-60 ng/mL.
Hi, these are my cousins results who I posted about recently - any comments regarding treatment etc would be appreciated..
Diagnosis: Graves’ disease, Vitamin D deficiency
Investigations: TSH receptor antibody significantly elevated at 12.5IU/L (0-1.5), TSH <0.01, fT3 33, fT4 92, Vitamin D 61nmol/L.
Ultrasound thyroid was a little enlarged with the right lobe measuring 49 x 15 x 17mm, left lobe 49 x 14.19mm.
is there a natural vitamin that can be taken to help with change of life symptoms after a hysterectomy?
The research team found that the level of circulating vitamin D in the blood affected the toll-like receptor (TLR) expression measured on white blood cell lymphocytes and monocytes. Specifically, they found that the TRL most affected by a vitamin D insufficiency is TLR7, which regulates the immune response against viruses.
org/home/pathogenesis/vitamind/metabolism, it is very detailed and addresses thyroid specifically about 2/3s through. There are others just search vit d receptor sites/ thyroid t3 receptor sites. The vit d replacement hype is not good and miss leads many into more chronic conditions. That's what makes this whole dosing frustrating and unsatisfactory, I have yet to find the answer and have experienced the negatives of d supplementation and hoping to prevent others from same.
When a T cell recognizes foreign invaders like bacteria or viruses, it sends activating signals to the vitamin D receptor gene. The VDR gene then starts producing DVR protein, which binds vitamin D in the T cell. Then the vitamin D bound and activated DVR produces PLC-gamma1 protein — which allows the T cell to get started fighting the infection.
Dr. John Cannell has also reported that vitamin D helps produce antibacterial peptides that help protect against the flu.
In addition, should this be combined with a VDR (vitamin D receptor) polymorphism, a genetic mutation, you would need supplementation at much higher levels, along with boosting cholesterol through diet and perhaps taking also cholesterol supplements. Look into Sonic Cholesterol supplements made from raw sheep's wool.
That is very bizarre, I didn't know that Vitamin D could have that effect. I'm currently taking 50,000 of prescription Vitamin D once a week for 4 weeks because I'm severely low. I'm on week 3 and I haven't noticed any hypo symptoms, my last tsh was .36. I will have it checked again in 2 weeks. Maybe it's the type of vitamin d you are taking? I don't know, but that is strange that there would be a relationship between the two. What does your doc say about it?
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The research team found that the level of circulating vitamin D in the blood affected the toll-like receptor (TLR) expression measured on white blood cell lymphocytes and monocytes. Specifically, they found that the TRL most affected by a vitamin D insufficiency is TLR7, which regulates the immune response against viruses.
the doctor who wrote it ran a treatment facility in UPstate New york where they gave patients amino acids and vitamin via IV during treatment.. He also counsels patients individually.. All of these things are meant to rebuild activity in the major neuro transmitters.. as addicts our neurotransmitters have been disrupted by our use of drugs.. even stuff like cigarettes and eating alot of sugar can disrupt them.. with drugs however it can be more damaging..
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