I had some issues with moodswings after detoxing off methadone, & for me it was a unfamilar feeling, because when I was on methadone I hardly had feelings, I never cried, then once off methadone, this all changed in a big way, I found myself crying for no reasons, & just wanting to be left alone. After a few weeks, the depression went away, but the anxiety & problems with sleep didnt, so I got onto trazodone, its a anti-depressant that helps with sleep.