Ribavirin mechanism of action

Common Questions and Answers about Ribavirin mechanism of action


Avatar m tn In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious HCV cell culture systems was studied. Similar to interferon (IFN)-α, ribavirin potently inhibits JFH-1 infection of Huh7.5.1 cells in a dose-dependent manner, which spans the physiological concentration of ribavirin in vivo.
Avatar m tn Our study suggests that ribavirin, acting by way of a novel innate mechanism, potentiates the anti-HCV effect of IFN. Understanding the mechanism of action of ribavirin would be valuable in identifying novel antivirals (HEPATOLOGY 2010;.). http://www.ncbi.nlm.nih.
Avatar f tn It is used in combination with interferon for the treatment of chronic hepatitis C. Although the exact mechanism of its action is unknown, it is thought to interfere with the production and/or action of viral DNA and RNA which are critical to the survival and multiplication of the virus. GENERIC: no PRESCRIPTION: yes PREPARATIONS: Capsule: 200 mg. STORAGE: Ribavirin should be refrigerated at 2-8 C (36-46 F).
223152 tn?1346981971 Ribavirin is a weak inhibitor of the HCV NS5B RNA polymerase in vitro, but its mechanism of action is not fully understood. This analysis included 93 chronic hepatitis C patients from 5 centers in Germany. Just over half were men and 78% had hard-to-treat HCV genotype 1. Within this group, 43 were treatment-naive, 28 were prior relapsers, and 19 were prior non-responders. All participants were initially treated with ribavirin monotherapy, at an average dose of 15.
Avatar n tn The mechanism of riba action is still under investigation but evidence is accumulating that it works by (1) promoting excessive mutation in the virus (2) inhibiting hcv polymerases's ability to make copies of the viral genome (<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
135456 tn?1301441224 BTW, re ntz, among the many things that remain to be shown is whether its effect on relapsers/nonresponders is significant. As far as I know, what's been released about its mechanism of action is "selectively inhibiting dephosphorylation of eukaryotic initiation factor 2α (eIF2α)".
Avatar m tn From Clinical Use Back to Molecular Mechanisms Posted 12/08/2008 "Ribavirin is an old broad-spectrum antiviral that is highly effective when used in combination with interferon-α and also as part of triple therapies containing new inhibitors of the hepatitis C virus (HCV) non-structural (NS)3/4 protease or HCV NS5B polymerase for the treatment of patients with chronic hepatitis C.
173930 tn?1196341998 Evolutionary psychology and cognitive science say this psychological trait might have evolved in our ancestral environment when real chances of survival were slim and some mechanism of self-delusion were necessary for performing high-risk tasks (hunting dangerous animals, tribal warfare, crossing harsh territories, etc.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
Avatar f tn boceprevir is in pharmacies now telaprevir should be by the end of the month they both have the same mechanism of action ( protease inhibitors ) and are comparable in efficacy mimi that 70% is for first timers only
2062505 tn?1331092888 While its mechanism of action has not been fully characterized, ondansetron is not a dopamine-receptor antagonist. Serotonin receptors of the 5-HT3 type are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone of the area postrema. It is not certain whether ondansetron’s antiemetic action is mediated centrally, peripherally, or in both sites.
142841 tn?1201978652 Not really -- I was asking if there was a second effect or mechanism of action of interferon on the thyroid. The interferon induced autoimmune attack of the thyroid would be indirect, if you will. I was asking about a more direct interaction with the thyroid. I guess it doesn't really matter in the end. Thanks NYgirl7, too, for the info.
158241 tn?1237723123 http://tinyurl.com/6759rg The ribavirin bioavailability of ribavirin can differ between two persons, even if they have the same height and bodyweight. Hence it just seems to be consequent to individualise the therapy more and more and to adapt the ribavirin DOSIS dependent on the individual CONCENTRATION. I predict a routine testing of riba-concentrations and individualised variation of dosis in a few years.
Avatar f tn ------------------------------------ No, in general, you are not off base, however there are a number of things to factor in such as your genotype, prior tx history if any, the amount of liver damage you have, your race, weight, height, age, doses of riba and peg, pre-tx hemoglobin and hemoglobin response during tx, etc. You might want to include some of all of this in your profile.
Avatar n tn In the current study, we investigated the antiplatelet mechanism of GTC. We tested the effects of GTC on the aggregation of human platelets and on the binding of fluorescein isothiocyanate-conjugated fibrinogen to human platelet glycoprotein (GP) IIb/IIIa. GTC inhibited the collagen-, thrombin-, adenosine diphosphate (ADP)-, and calcium ionophore A23187-induced aggregation of washed human platelets, with 50% inhibitory concentration values of 0.64, 0.52, 0.63, and 0.45 mg/ml, respectively.
Avatar m tn Thus, increased expression of innate antiviral factors and the different modulation of genes involved in cholesterol metabolism and efflux suggest a new mechanism of action mediated by thiazolides. Parole chiave: thiazolides ; influenza ; HIV-1 ; nitazoxanide Settori scientifico disciplinari: MED/04 - Patologia Generale Citazione: IMMUNOMODULATORY EFFECTS OF NITAZOXANIDE AND RELATED MOLECULES : corso di MEDICINA MOLECOLARE / Federica Gnudi ; tutor: M. Clerici ; coordinatore: M. Clerici.
1118724 tn?1357014191 1 Mechanism of Action Ribavirin is an antiviral drug [see Microbiology (12.4)]. 12.4 Microbiology Mechanism of Action The mechanism by which ribavirin contributes to its antiviral efficacy in the clinic is not fully understood. Ribavirin has direct antiviral activity in tissue culture against many RNA viruses. Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
131817 tn?1209532911 A recent study that modelled the impact of ribavirin on IFN therapy has provided further insight into the mechanism of action of ribavirin.[45] This study tested the hypothesis that ribavirin acts by causing lethal mutagenesis to the virus, and the traditional model was, therefore, extended to incorporate a term accounting for these effects. The results fit well into this revised model.
1253246 tn?1332076910 When you have more information you will be able to either relax or at least formulate a plan of action. You have come through to one of the best forums in the world so you are already on a winner.Keep reading and posting questions. Welcome to you also.
1084115 tn?1385232189 //www.aic.cuhk.edu.hk/web8/ribavirin.htm Here is an easier to understand article on the mode of action of Ribavirin: For the treatment effect of ribavirin, mainly three assumptions on treatment mechanisms have been analysed. Firstly, ribavirin may mainly block viral production. The total effect can be estimated by a viral kinetic parameter describing the treatment efficacy.
233616 tn?1312790796 The depression that occurs during viral infections is mediated via the production of interferon. This action of interferon requires the synthesis of an intermediate protein(s) yet to be identified. Using an oligonucleotide probe for a unique sequence in cytochrome P-450LA omega we have now shown that the mRNA for this isozyme is depressed following the administration of interferon inducers. The magnitude in the loss of mRNA corresponds to the magnitude of the loss in the levels of this isozyme.
Avatar m tn Replicative homeostasis also suggests a primarily non-immunological mechanism that mediates increased immune responsiveness during treatment with ribavirin (and other nucleos(t)ide analogues), explicating the enhanced second-phase clearance of HCV ribavirin promotes and, thus, the apparent immunomodulatory action of ribavirin. More importantly, RH suggests specific new antiviral therapeutic strategies...
Avatar m tn However, the putative mechanism of action of Viusid is unknown. A research article to be published on June 7, 2010 in the World Journal of Gastroenterology addresses this question. The authors reported the results of a randomized double-blind and placebo-controlled study to evaluate the effect of Viusid on oxidative stress and cytokine parameters in patients with CHC who had been nonresponders to previous antiviral therapy with peginterferon plus ribavirin and infected with genotype 1.
374652 tn?1494815035 In the group of previously treated patients the SVR was 25% in the group who received the triple therapy compared to 8 percent in the group who received the dual therapy. The speaker commented that the mechanism of action is not really understood and that larger studies are needed to confirm these findings and to understand the mechanism of action.
244899 tn?1313628239 I was ON SOC, Pegasys and Ribavirin..was told to eats lots of fat by the people here as well.
220090 tn?1379170787 In any case, if 'wiped out' means halted from replicating then there's still the question of how long it takes after that for infected cells to get cleared out. But yes I agree, every mechanism of action helps, doesn't it. The sooner replication is stopped, the less infected cells there will be in line for elimination. Somehow I like the conclusion of the Drusano study which says it takes 36 weeks after UND.
Avatar n tn She is so exhausted that she can't fight no more against medical community in order to admit the origin of her symptoms and to push them to try to find a beginnning of solution. Is there any progress in the comprehension of the cause of these symptoms ? Are there some new treatments that appeared recently to counteract exhaustion and pains ? Do people group themselves in associations to better fight against this disaster ?
Avatar f tn Each compound has its own unique mechanism of action, which supports the potential for developing these compounds together as a dual nucleotide regimen and as part of combination therapy regimens with Vertex's other approved and investigational medicines for chronic hepatitis C, including INCIVEKTM (telaprevir), an FDA-approved hepatitis C protease inhibitor, and VX-222, an investigational hepatitis C non-nucleoside polymerase inhibitor.
237222 tn?1202512241 How agressively will you use helper drugs to keep me on treatment as opposed to lowering my dose of either Peg or ribavirin. 7. What criteria do you use to prescribe Procrit (epo)? I it just an absolute hemoglobin number or do you also base it on the drop from pre-treatment baseline and how the patient feels? How often do you prescribe the helper drug Neupogen and what criteria (ANC value) do you use in determining whether or not to use it. 7.
100019 tn?1335923317 It was common in the earlier days of SOC treatment for patients to receive a fixed dose of 800mg of ribavirin. The dose was not adjusted to accommodate for variances in weight, and was NOT optimum for heavier patients (with "heavier" being defined as basically anyone over 150 lbs or so). As you can imagine, a woman weighing 130lbs taking 800mg of riba a day will have a much higher riba blood serum concentration than Lumpy Lewinski weighing in at 400 lbs and also taking 800mg/daily.