Ribavirin mechanism

Common Questions and Answers about Ribavirin mechanism


Avatar m tn When ribavirin is used in conjunction with IFN-α, induction of specific ISGs is synergistic when compared with either drug applied separately. Direct up-regulation of these antiviral genes by ribavirin is mediated by a novel mechanism different from those associated with IFN signaling and intracellular double-stranded RNA sensing pathways such as RIG-I and MDA5. RNA interference studies excluded the activation of the Toll-like receptor and nuclear factor κB pathways in the action of ribavirin.
Avatar m tn Our study suggests that ribavirin, acting by way of a novel innate mechanism, potentiates the anti-HCV effect of IFN. Understanding the mechanism of action of ribavirin would be valuable in identifying novel antivirals (HEPATOLOGY 2010;.). http://www.ncbi.nlm.nih.
Avatar f tn Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material. Though not effective against all viruses, ribavirin has important activities against influenzas, flaviviruses and agents of many viral hemorrhagic fevers. Ribavirin is a pro-drug, meaning that it is a chemical precursor for the actual phamacologically active molecule.
Avatar n tn Hi to everybody! I was trying to find any studyies about lowering the ribavirin dosage and outcome of tx.. anyone has done some googleing about it??? Got great neews! got finaly my week 2 test; form 7.7 million units, to 1.1 million units!! ..when u can consider your self an early responder?? ..i know, i'm such a winer.. i'm on my 6/48 week, and allready wining..
Avatar f tn Ribavirin is an antiviral drug. It is used in combination with interferon for the treatment of chronic hepatitis C. Although the exact mechanism of its action is unknown, it is thought to interfere with the production and/or action of viral DNA and RNA which are critical to the survival and multiplication of the virus. GENERIC: no PRESCRIPTION: yes PREPARATIONS: Capsule: 200 mg. STORAGE: Ribavirin should be refrigerated at 2-8 C (36-46 F).
223152 tn?1346981971 Based on the fact that interferon monotherapy is not effective, it's effective with ribavirin, and at full strength, I would rather have my ribavirin working at full strength when I start my interferon than have it take awhile after my interferon to get to full strength. There IS data on the amount of time it takes for ribavirin to get to full concentration AND there is data on the efficacy of ribavirin together with interferon.
Avatar n tn How important is it to be taking a full ribavirin dosage late in treatment? I am male, 39yrs, 140lb, genotype 1a, in week 34 of peg-intron+riba treatment. I started tx with a viral load of 3,000,000IU/m. Viral load tests were undetectable at 12 and 24 weeks (yay!). However, I have not been tolerating the ribavirin very well - anemia, fatigue, the usual... My starting riba dosage was 800mg/day, but I have been at that dosage for only a total of 8 weeks (out of 34 weeks so far).
135456 tn?1301441224 Have you had previous experience with 1600 mg/day of ribavirin? If not, you might start sooner and titer up more gradually to make sure that you can handle the dose. Keep in mind that it can take 1-3 weeks for a change in ribavirin dose to be reflected in your hemoglobin. Also, and again based on your previous treatment experience, consider Procrit (epo) coincidental with the riba pre-dosing for same reasons.
Avatar n tn It was only five ago that Shane Crotty and his fellow scientists identified the mechanism by which ribavirin causes "error catastrophe" in our favorite virus: <a href=http://www.sciencedaily.com/releases/2000/12/001208073913.htm><b>Antiviral Drug Works By Causing "Genetic Meltdown"</b></a> It's really a shame that we can't replicate the Swedish experiment by testing for serum saturation.
233616 tn?1312790796 The complete mechanism of antiviral activity of ribavirin is unknown, and intracellular phosphorylation of ribavirin is believed to be required to exert its antiviral activity. Marked improvements in the sustained viral response (SVR) were achieved when peg-interferon was combined with ribavirin. It has been found that higher rates of SVR could be achieved with higher ribavirin concentrations in genotype 1-infected patients.
135456 tn?1301441224 I haven't been able to find any ribavirin pre-dosing studies, although someone did post here about a year ago which suggested that one such study may exist. If so, it appears to be a carefully guarded secret :) That said, the concept of pre-dosing ribavirin makes sense to this non-medical professional on a logical basis. Since it takes 2-4 week for ribavirin to reach maxium serum levels, then in a sense, if we don't pre-dose ribavirin, we are under-dosed for the first 2-4 weeks of treatment..
Avatar m tn In this study, we compared hepatic gene expression in patients prior to and during peginterferon and ribavirin therapy. In the on-treatment group, patients received either ribavirin for 72 hours prior to peginterferon alpha-2a injection or peginterferon alpha-2a for 24 hours, prior to biopsy. The patients were grouped into rapid responders (RRs) with a greater than 2-log drop and slow responders (SRs) with a less than 2-log drop in hepatitis C virus RNA by week 4.
173930 tn?1196341998 Evolutionary psychology and cognitive science say this psychological trait might have evolved in our ancestral environment when real chances of survival were slim and some mechanism of self-delusion were necessary for performing high-risk tasks (hunting dangerous animals, tribal warfare, crossing harsh territories, etc.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
Avatar n tn I was wondering whether anyone had received cautions from their physician about possible carcinogeneic effects of ribavirin. The Roche/Rebetol docs do note that it is mutagenenic and "should be considered a potential carcinogen" and recent research on its effectiveness against hcv indicates that at least one of the mechanisms is via mutagenesis ("Ribavirin's antiviral mechanism of action:lethal mutagenesis?", J. Mol. Med 80:86, 2002 on pubmed).
Avatar m tn It's an approximate computation based on the half life of ribavirin which is quite long. My guess it's probably a bit on the conservative side but why take a risk when potential birth defects are involved.
1118724 tn?1357014191 1 Mechanism of Action Ribavirin is an antiviral drug [see Microbiology (12.4)]. 12.4 Microbiology Mechanism of Action The mechanism by which ribavirin contributes to its antiviral efficacy in the clinic is not fully understood. Ribavirin has direct antiviral activity in tissue culture against many RNA viruses. Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
1084115 tn?1385232189 Indeed, a triphasic viral decline has been observed in clinical data, particularly in patients treated with standard doses of (pegylated) interferon plus ribavirin, and, therefore, such a mechanism of ribavirin can be explained by these models (41, 43–46). Lastly, ribavirin may influence the infectivity of newly produced virus.
374652 tn?1494815035 40 patients who received pegylated interferon plus ribavirin (control arm) for 48 weeks. 2. 28 patients who received nitazoxanide for 12 weeks followed by 36 weeks of nitazoxanide plus pegylated interferon (dual therapy), 3.
Avatar n tn A recent study that modeled the impact of ribavirin on IFN therapy has provided further insight into the mechanism of action of ribavirin.[45] This study tested the hypothesis that ribavirin acts by causing lethal mutagenesis to the virus, and the traditional model was, therefore, extended to incorporate a term accounting for these effects. The results fit well into this revised model.
Avatar m tn Furthermore, in these nitazoxanide- and tizoxanide-resistant cell lines, the anti-HCV effects of ribavirin remained constant and susceptibility to interferon was increased several-fold. The mechanism of interaction between tizoxanide and interferon alfa is still under investigation, but it is proposed that nitazoxanide and tizoxanide inhibit HCV replication by a cell-mediated mechanism and not via a virus-specific mechanism.
568322 tn?1370169040 Study Results: PegIntron + Ribavirin........... RVR 6.1%......SVR 38.7% PegIntron+ Ribavirin+ Actos....RVR 27%.......SVR 60.4% Liver Int. 2009 Nov 16. Pioglitazone (Actos) improves virological response to peginterferon alpha-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance. Khattab M, Emad M, Abdelaleem A, Eslam M, Atef R, Shaker Y, Hamdy L. Department of Internal Medicine, Minya University, Minya, Egypt.
Avatar f tn The interferon (IFN)-free regimen of sofosbuvir and ribavirin for 24 weeks was recently approved to treat chronic hepatitis C virus (HCV) genotype 1 (GT-1) infection for patients ineligible for IFN. However, sofosbuvir plus ribavirin therapy is associated with relapse in 15% to 30% of patients with HCV GT-1. Neither the mechanism of relapse nor the optimal re-treatment strategy for these patients is defined.
7510956 tn?1411675017 Ribavirin (an antiviral drug) work differently and are processed differently in the body so there is no correlation between the dosing of these very different drugs. * Ribavirin Mechanism of Action The mechanism by which ribavirin contributes to its antiviral efficacy in the clinic is not fully understood. Ribavirin has direct antiviral activity in tissue culture against many RNA viruses (such as HCV).
Avatar m tn Accumulating data are available today that aim to explain the distinct molecular mechanisms of the ribavirin mode of action. Generally, none of the proposed mechanism seems to account solely for the clinical benefit of ribavirin.
87972 tn?1322664839 At higher doses, ribavirin may either augment previously proposed antiviral pathways, act through a novel mechanism or, perhaps, at higher doses more patients achieve a critical threshold of intracellular ribavirin concentration. Unfortunately, the results of Lindahl and coworkers seem to raise more questions than to provide answers as to the mechanism of action of ribavirin. Clearly more research is needed in this area.
Avatar n tn Am at 24 weeks and just got results back...virus undetectable. I'm genotype 1, over 60, and long term. Dr. has me on peginterferon + ribavirin. At 12 weeks, just barely 2 log drop. Then started daily Vitamin D supplements (5000mg) after reading latest studies. Doc was hesitant but agreed. Now says was good idea. I hope this helps someone out their. Just hoping no relapse for next 24 weeks. Have had gradually increasing neutropenia but still over the <500 limit and still asymptomatic.