Ribavirin action

Common Questions and Answers about Ribavirin action


Avatar m tn In order to further characterize the mechanisms of action of ribavirin, we examined the effect of ribavirin treatment on ISG induction in cell culture. In addition, the effect of ribavirin on infectious HCV cell culture systems was studied. Similar to interferon (IFN)-α, ribavirin potently inhibits JFH-1 infection of Huh7.5.1 cells in a dose-dependent manner, which spans the physiological concentration of ribavirin in vivo.
Avatar m tn Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Thomas E, Feld JJ, Li Q, Hu Z, Fried MW, Liang TJ. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. Abstract The combination of pegylated interferon (PEG-IFN) and ribavirin is the standard treatment for chronic hepatitis C.
8683847 tn?1410760916 Good ole Ribavirin. What your having is pretty common. Wishing you the best.
Avatar f tn //www.medicinenet.com/ribavirin/article.htm GENERIC NAME: ribavirin BRAND NAME: Rebetol, Copegus DRUG CLASS AND MECHANISM: Ribavirin is an antiviral drug. It is used in combination with interferon for the treatment of chronic hepatitis C. Although the exact mechanism of its action is unknown, it is thought to interfere with the production and/or action of viral DNA and RNA which are critical to the survival and multiplication of the virus.
Avatar n tn How to decide to do interferon/ribavirin? I am having a great deal of ambivalence about beginning this treatment. And a lot of fear. The docs think I should go ahead -- I've probably had Hep C for close to 30 years (I'm 46) from one incident of "we have to try everything once" injecting heroin. I've been diagnosed for 5 years, genotype 2B with a biopsy five years ago grade 1 stage 0. I have quite a bit of fatigue and have struggled (under control at this time) with clinical depression.
223152 tn?1346981971 Based on the fact that interferon monotherapy is not effective, it's effective with ribavirin, and at full strength, I would rather have my ribavirin working at full strength when I start my interferon than have it take awhile after my interferon to get to full strength. There IS data on the amount of time it takes for ribavirin to get to full concentration AND there is data on the efficacy of ribavirin together with interferon.
Avatar m tn My concern with the antacids is that they might intefere with ribavirin absorption. Very little in the literature conclusive one way or the other. Wondering if any of you also take antacids and if you take them right after meals with your riba, or if you try to time the antacids a few hours before or after the riba.
Avatar n tn How important is it to be taking a full ribavirin dosage late in treatment? I am male, 39yrs, 140lb, genotype 1a, in week 34 of peg-intron+riba treatment. I started tx with a viral load of 3,000,000IU/m. Viral load tests were undetectable at 12 and 24 weeks (yay!). However, I have not been tolerating the ribavirin very well - anemia, fatigue, the usual... My starting riba dosage was 800mg/day, but I have been at that dosage for only a total of 8 weeks (out of 34 weeks so far).
135456 tn?1301441224 Have you had previous experience with 1600 mg/day of ribavirin? If not, you might start sooner and titer up more gradually to make sure that you can handle the dose. Keep in mind that it can take 1-3 weeks for a change in ribavirin dose to be reflected in your hemoglobin. Also, and again based on your previous treatment experience, consider Procrit (epo) coincidental with the riba pre-dosing for same reasons.
Avatar f tn The cycle will continue to repeat over and over again while in the mutating presence of ribavirin and antiviral action of IFN, eventually resulting in eradication. But under the circumstances described above, since the mutation rate has been increased, its possible a pre-existing VX resistant dominant population could be mutated out of its resistance.
1961140 tn?1450742312 While Sofosbuvir is expensive, the treatment as a whole is cheaper than the triple med treatment with Interferon, Ribavirin, and a Protease Inhibitor. I treated for 48 weeks with triple med Tx. Incivek was about $64,000 for 12 weeks of Incivek. A total of 48 weeks of Tx with Inteferon and Ribavirin was about $25,000 for the Interferon and about $17,000 for the Ribavirin. Well, that totals about $106,000 for 48 weeks of Tx.
173930 tn?1196341998 I was on a drug trial for Schering Plough so they just tried Procrit 40,000iu each week and dose reduced my ribavirin from 1200mg to 1000mg. Even after 6 months on this treatment I never got above 9.5. So they dropped me from the trial. You should dose reduce the riba and start on the EPO/Procrit ASAP, I started with 40,000iu but you can double that dose. Also start taking 1000mg of vitamin C and 800mg of vitamin E this will help to boost your HGB.
334847 tn?1206533840 on VX-950 on the boards (not like I used to - might be because I'm not looking in the right place), but anyhow - I came by to see if anyone had posted on the class action law suit that's been filed against Vertex (on behalf of investors / stock holders). Was just wondering - have you all heard this? I've gotten several news alerts on it in the last several days. Thought some here might be interested.
Avatar m tn I have Hep-C G2. Started SOVALDI and Ribavirin 12 week treatment Dec 23, 2013 (viral load at 2.5 million), within 4 weeks into treatment my Hep C virus was undetectable. 12 weeks end of treatment my Hep C virus was undetectable. 4 weeks after treatment my Hep C virus was undetected. 12 weeks after of treatment my Hep C virus was detected at 83,000 viral load. It relapsed. What are my chances of a cure now?
Avatar f tn I just wanted to say that when I treated with Ribavirin and Interferon the doctor told me to be careful after finishing tx because my immune system had been so ramped up during tx that I could get ill after finishing, while my immune system tried to recover from the tx. I know you used the Sovaldi but I thought it could be the same premise. Also, once you get sick it is so easy to get sick again as your body is more susceptible.
135456 tn?1301441224 Tizoxanide, the major NTZ metabolite, is 99% bound to protein and could interfere with other protein bound drugs in plasma. Ribavirin is readily soluble in water, so it is likely not dependent on plasma protein transport, but respective data in the official files in this regard are not available. Food affects the bioavailibility of NTZ by about a factor of two.
Avatar m tn From Clinical Use Back to Molecular Mechanisms Posted 12/08/2008 "Ribavirin is an old broad-spectrum antiviral that is highly effective when used in combination with interferon-α and also as part of triple therapies containing new inhibitors of the hepatitis C virus (HCV) non-structural (NS)3/4 protease or HCV NS5B polymerase for the treatment of patients with chronic hepatitis C.
3140551 tn?1343255037 //pi.vrtx.com/files/uspi_telaprevir.pdf Ribavirin monotherapy is not effective for the treatment of chronic hepatitis C virus infection and should not be used alone for this indication. http://www.drugs.com/pro/ribavirin.
Avatar m tn 16 Ribavirin The synthetic purine nucleoside Ribavirin rapidly enters eukaryotic cells and after intracellular phosphorylation exhibits virustatic activity against a broad spectrum of DNA and RNA viruses.25 Several studies have been conducted to evaluate ribavirin monotherapy in daily doses of 600-1,200 mg in the treatment of chronic hepatitis C.26-28 While all trials consistently showed a decrease in aminotransferase levels, no virologic end-of-treatment responses were observed.
173930 tn?1196341998 Prediction of sustained virological response in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) and ribavirin. Foster GR, Fried MW, Hadziyannis SJ, Messinger D, Freivogel K, Weiland O. The Royal London Hospital. London. UK. Objective. Patient- and virus-related factors influence the response of patients with chronic hepatitis C to interferon-based therapy.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
Avatar f tn D reports that 61-80% of Hep C Genotype 1 participants who were previous treatment failures or null responders with Cirrhosis achieved SVR with TMC435 combined with Interferon and Ribavirin.
Avatar f tn Abbott (ABT) will be presenting information at the AASLD meeting in Boston, Nov, 2012, regarding it's triple DAA regimen which produced high rates of SVR both in treatment naive and null responders both with and without Ribavirin, although results with Ribavirin are higher. According to ABT's press release, the SVR rates after 12 weeks of treatment were: GT1, treatment naive 97.5% SVR, null responders 93.
1118724 tn?1357014191 1 Mechanism of Action Ribavirin is an antiviral drug [see Microbiology (12.4)]. 12.4 Microbiology Mechanism of Action The mechanism by which ribavirin contributes to its antiviral efficacy in the clinic is not fully understood. Ribavirin has direct antiviral activity in tissue culture against many RNA viruses. Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
1084115 tn?1385232189 2012 Mode of action Hypotheses include: *ribovarin monophosphate inhibits inosine monophosphate dehydrogenase which results in decreased synthesis of guanosine triphosphate (GTP).
374652 tn?1494815035 40 patients who received pegylated interferon plus ribavirin (control arm) for 48 weeks. 2. 28 patients who received nitazoxanide for 12 weeks followed by 36 weeks of nitazoxanide plus pegylated interferon (dual therapy), 3.
Avatar n tn A recent study that modeled the impact of ribavirin on IFN therapy has provided further insight into the mechanism of action of ribavirin.[45] This study tested the hypothesis that ribavirin acts by causing lethal mutagenesis to the virus, and the traditional model was, therefore, extended to incorporate a term accounting for these effects. The results fit well into this revised model.