Ribavirin hemolytic anemia

Common Questions and Answers about Ribavirin hemolytic anemia


Avatar n tn html) there's a silver lining to early-onset hemolytic anemia during Pegasys/Ribavirin treatment. At least in patients with the less responsive Genotypes 1a and b it seemed to indicate a better chance of sustained viral response (that is of remaining virus free six months after treatment) after protocol completion.
Avatar f tn http://www.medhelp.
188500 tn?1207368551 Ribavirin can make you feel "shaky and speedy". We often joke about "ribarage" but it seems a very real condition for many of us during treatment. It's been defined in many different ways but for me it was a loss of emotional control where I often literally "snapped" at times -- shouting at people in traffic, throwing a fit in a doctors office after waiting too long, hanging up on someone on the phone. Stuff I just didn't do before treatment and haven't done since.
Avatar m tn Unfortunately, ribavirin can cause hemolytic anemia; his is due to the premature destruction of red blood cells. The choices are either dose reduction of ribavirin, or intervention with Procrit (or other Epo formulas).
Avatar f tn Hi. What occurs in some doing HCV therapy is drug induced "hemolytic anemia" caused both by the Interferon and Ribaniron. The Riba destroys the oxygen carrying "red blood cell" before its maturity and the Interferon suppress the bone marrow from reproducing these cells fast enough to keep up,so a it of a double whammy ....hence the anemia. When the medications so is this destructive process..
Avatar n tn Hi Karen, Anemia is caused by the oral component ribavirin. It is hemolytic anemia; in other words, red blood cells which are normally destroyed by our body every 100 days or so now die off sooner; more quickly than many of our systems can replace. It is managed with either the drug Procrit, or by dose reduction of ribavirin. If these measures don’t work, transfusion is possible, along with treatment cessation. The last two methods aren’t common, but are required as last ditch measures.
Avatar f tn The current polymerase inhibitor class drugs Teleprevir and Boceprevir both include interferon and ribavirin; it’s primarily the riba that is responsible for hemolytic anemia we experience. Not all of us get anemia so badly that it requires intervention; I don’t have an exact number, but I suppose approximately 30% require dose reduction or Procrit to manage. A call to the treating doctor himself is probably in order; explain your problem to him directly to give him the opportunity to respond.
Avatar n tn Hi GK, It’s good to hear he received a transfusion. Most doctors consider intervention for ribavirin-induced hemolytic anemia at around 10.0 g/dL. Many will consider transfusion at 8.5, so your husband was well overdue. Keep in mind that the end-point for hemolytic anemia is cardiac failure; this is something that is can be a serious issue, obviously. Intervention can consist of dose reduction, dose cessation, Rx with Procrit, Epogen, and Aranesp. These are all forms of human epoetin.
Avatar n tn i have to take decision whether to start ribavirin therapy or not,as one of its sidefect is HEMOLYTIC ANEMIA or i should first make her hemoglobin level correct then start ribavirin and interferon therpy. plz reply as soon as possible as i have to start her treatment soon.
Avatar n tn (Epogen) It is used for hemolytic anemia which is caused by the Riba. 9.9 isn't terribly bad but it's low and Procit takes several weeks to work so that is something you should discuss with your doctor immediately. If your hgb continues to drop rapdidly you may have to dose reduce until the Procrit starts working but that will prevent future riba dose reductions. You are in wk 32 and dose reduction is not as critical if as it would be prior to becoming UND.
Avatar n tn The doctors should know better but many really don't. Maybe if they had riba-induced (hemolytic) anemia once in their life they would move faster.
Avatar f tn com/hepatitis-c/hepatitis-c-topics/hcv-treatment/3583-easl-ribavirin-dose-reduction-and-epo-both-work-for-managing-anemia-in-patients- Reducing the dose of ribavirin and adding erythropoietin are both good options for managing anemia in hepatitis C patients treated with boceprevir (Victrelis) triple therapy, according to study findings presented at the 47th International Liver Congress (EASL 2012) this week in Barcelona.
Avatar f tn Someone on here had pointed out to me, that the hemolytic anemia may raise the pulse, so I was happy to see that it was still low. I havent had any ill sx, from the Procrit, at 40,000 iu's a week.
Avatar m tn unfortunately a serum concentration labtest for Riba is not available so the only way is by looking for it`s #1 toxicity namely hemolytic anemia. People predose Riba to make sure to have enough onboard when INF does it`s first strike , they don`t order extra fries for that purpose. burned74: Do you remember your HgB levels from your first tx ?
Avatar f tn Once they ruled out hemolytic anemia, which I assume they did first off, they should have tested you for infection, have they still not done that? If you have no infection, and anemia is ruled out, then the possibility that the riba is causing lung changes does exist. I read a couple of articles on this in pubmed a year ago, regarding changes that riba can cause to the mucousa.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
276730 tn?1327966546 By the way, I have nver read here (over a few years now) anyone who has incurred Aplastic Anemia for tx, Hemolytic anemia - lots. But, that just my observation. If you did start tx this week, you would not have 75 million next week. Besides, it's not a matter of how many you have, it's a matter of how few (like zero) you have.
Avatar f tn Hemolytic Anemia is different, it is caused by the meds you are taking. Your Doctor should treat you now, if you are as low as 9. Generally,if the HGB goes below 8 a blood transfusion is in order. Your Doctor can reduce your Ribaviran, or prescribe you a rescue med, called Procrit.
Avatar n tn Riba mostly gave me really bad hemolytic anemia and a REALLY bad attitude. Oh, yeah, and the trots! I got SVR so it was worth it.
Avatar f tn When your HGB drops below 10 for medical reasons, or in people on HCV tx in response to ribavirin in their blood it called Hemolitic anemia " This is not the anemia often called iron poor blood where you can eat food with more iron or take iron supplements to raise your HGB. "(Hemolytic anemia is a condition in which there are not enough red blood cells in the blood, due to the premature destruction of red blood cells.
26471 tn?1211940121 There are still doctors out there who will cut riba dosing instead of adding Procrit - which has come under more safety scrutiny lately, as I'm sure you know, and is off-label for ribavirin anemia. Some insurances won't pay for it. Some high-dose riba patients have needed transfusions to get them through therapy. I think for the most part, doctors suffer from a lack of information on the efficacy of high-dose ribavirin, as well as a powerful motivation to keep from getting sued.
Avatar f tn No. Hemolytic anemia is a common side effect of Ribavirin. (hemoglobin <10 g/dL) Just like a car, your body needs fuel to run. Hemoglobin, or Hb, is important because it transports oxygen in your blood to all parts of your body. Think of the oxygen carried by hemoglobin as the fuel your body needs to stay alive and run efficiently. Hemoglobin is a substance found in your red blood cells that carries most of your oxygen.
Avatar m tn High iron does mean you will not experience hemolytic anemia which can be caused by both the Incivek and ribavirin. Tylenol is recommended by most hepatologists, up to 2000 mg per 24 hr period. 20 g of fat is not required with Victrelis but it must be taken with food for maximum absorption benefit.
Avatar f tn The neupogen will work fast to help fix up the white blood cells - Epogen (brand name Procrit) is what we take for the hemolytic anemia it takes longer to work (a few weeks) but it quite effective and has saved many of us from having to drop out. I don't know which particular sides you are speaking about but yes most of us have had them - different ones at different times. It seems like as soon as you beat one another one pops up.
1838299 tn?1403496143 No, the anemia from HCV therapy is distinct from say, iron-deficient anemia. Ribavirin causes ‘hemolytic anemia’; red blood cells are destroyed more rapidly than they can be replaced by your body. This occurs naturally anyway; normally they have a lifespan of roughly 100 days, but the HCV drugs hasten this process. Other forms of anemia occur on the other end of spectrum; red cells aren’t produced rapidly enough, for instance.
Avatar m tn Compared with ribavirin, however, taribavirin is less likely to cause hemolytic anemia, a side effect that often necessitates ribavirin dose reduction or discontinuation. But taribavirin is more likely to cause diarrhea. Week 12 results from the study were presented this past April at the annual meeting of the European Association for the Study of the Liver (EASL 2008).
233616 tn?1312790796 Anemia is a common side effect of treatment for chronic hepatitis C virus (HCV) infection, due to red blood cell destruction (hemolytic anemia) caused by ribavirin and bone marrow suppression related to interferon. Erythropoietin (Procrit) and other erythropoiesis-stimulating agents (ESAs) that boost red blood cell production may be used to manage anemia.
Avatar m tn Anemia limits the option to treat hepatitis C, since the ribavirin will predictably exacerbate a pre-existing anemia, and may actually result in a fall in hemoglobin that is unacceptable. As a result, patients with anemia have often not been offered treatment for hepatitis C. Anemia often complicates anti-viral therapy for hepatitis C, again more often and more severely in patients who are co-infected with HIV.
Avatar f tn html These data suggest that timing, duration and extent of ribavirin dose reduction did not substantially impact SVR in the telaprevir treatment arms. Since ribavirin dose reduction was the mainstay of anemia management in the telaprevir development programme, these data suggest that reducing the ribavirin dose did not impact SVR rates.