Ribavirin and hemolytic anemia

Common Questions and Answers about Ribavirin and hemolytic anemia

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Avatar n tn html) there's a silver lining to early-onset hemolytic anemia during Pegasys/Ribavirin treatment. At least in patients with the less responsive Genotypes 1a and b it seemed to indicate a better chance of sustained viral response (that is of remaining virus free six months after treatment) after protocol completion.
Avatar m tn It all depends on the rate of drop and how your body reacts. BTW I was cleaning up the other day and came across a little pink riba pill on the floor. Got all choked up.
Avatar f tn I would love any input/advise, from those who have been on Triple Tx, and experienced anemia, and used Procrit, and Riba reduction~ I am 13 shots down, and have 15 shots to go, so there is alight at the end of this achey`itchy tunnel, and thank you in advance~
188500 tn?1207368551 Ribavirin can make you feel "shaky and speedy". We often joke about "ribarage" but it seems a very real condition for many of us during treatment. It's been defined in many different ways but for me it was a loss of emotional control where I often literally "snapped" at times -- shouting at people in traffic, throwing a fit in a doctors office after waiting too long, hanging up on someone on the phone. Stuff I just didn't do before treatment and haven't done since.
Avatar m tn Unfortunately, ribavirin can cause hemolytic anemia; his is due to the premature destruction of red blood cells. The choices are either dose reduction of ribavirin, or intervention with Procrit (or other Epo formulas).
Avatar f tn Hi. What occurs in some doing HCV therapy is drug induced "hemolytic anemia" caused both by the Interferon and Ribaniron. The Riba destroys the oxygen carrying "red blood cell" before its maturity and the Interferon suppress the bone marrow from reproducing these cells fast enough to keep up,so a it of a double whammy ....hence the anemia. When the medications so is this destructive process..
Avatar n tn Bill, I was told years ago that I had pernicious anemia and now I'm testing postive for anemia too. My anemia levels were HCG 11.2 low and RBC 4.02 low which isn't horrible but low. I keep thinking that the tests must be coming in soon!
Avatar f tn The current polymerase inhibitor class drugs Teleprevir and Boceprevir both include interferon and ribavirin; it’s primarily the riba that is responsible for hemolytic anemia we experience. Not all of us get anemia so badly that it requires intervention; I don’t have an exact number, but I suppose approximately 30% require dose reduction or Procrit to manage. A call to the treating doctor himself is probably in order; explain your problem to him directly to give him the opportunity to respond.
Avatar n tn Hi GK, It’s good to hear he received a transfusion. Most doctors consider intervention for ribavirin-induced hemolytic anemia at around 10.0 g/dL. Many will consider transfusion at 8.5, so your husband was well overdue. Keep in mind that the end-point for hemolytic anemia is cardiac failure; this is something that is can be a serious issue, obviously. Intervention can consist of dose reduction, dose cessation, Rx with Procrit, Epogen, and Aranesp. These are all forms of human epoetin.
Avatar n tn I had anemia that was procrit dependent going into treatment - anemia of unknown or chronic disease (possibly an auto-immune hemolytic anemia as it turns out). I did treat with ribavirin and interferon, and I had a lot of difficulties with anemia. Early on, I began taking 40,000 units of procrit (well, epogen in my case) twice a week. It really didn't touch the anemia. I had blood transfusions every 10 to 14 days while treating and I had a successful treatment and I am now SVR.
Avatar n tn (Epogen) It is used for hemolytic anemia which is caused by the Riba. 9.9 isn't terribly bad but it's low and Procit takes several weeks to work so that is something you should discuss with your doctor immediately. If your hgb continues to drop rapdidly you may have to dose reduce until the Procrit starts working but that will prevent future riba dose reductions. You are in wk 32 and dose reduction is not as critical if as it would be prior to becoming UND.
Avatar n tn The reason I don't just add it is because they still can't get the anemia under control with the 4 I'm taking and I am on Aranesp for the anemia. That is why I am hesitant I thought maybe if I tried every other day I could build up to it.
Avatar f tn Was an early responder and SVR for next 6 months but then developed severe anemia. Was hospitalized 5 days and doctors reduced ribavirin dosage to 2 am and 2 pm(instead of 3 in the pm). Two or three weeks after I got out of hospital the virus returned." It is the last one on this thread: http://www.medhelp.org/posts/Hepatitis-C/diet-on-incivek/show/1547942#post_8273344 ________________ This could require tweaking and others might have better more clinically productive ideas.
Avatar f tn -----------------------DOSAGE AND ADMINISTRATION ----------------------- • 800 mg administered orally three times daily (every 7 to 9 hours) with food (a meal or light snack). (2) • VICTRELIS must be administered in combination with peginterferon alfa and ribavirin. (2) • Refer to peginterferon alfa and ribavirin Package Inserts for specific dosing instructions. (2) http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
Avatar f tn No. Hemolytic anemia is a common side effect of Ribavirin. (hemoglobin <10 g/dL) Just like a car, your body needs fuel to run. Hemoglobin, or Hb, is important because it transports oxygen in your blood to all parts of your body. Think of the oxygen carried by hemoglobin as the fuel your body needs to stay alive and run efficiently. Hemoglobin is a substance found in your red blood cells that carries most of your oxygen.
Avatar m tn High iron does mean you will not experience hemolytic anemia which can be caused by both the Incivek and ribavirin. Tylenol is recommended by most hepatologists, up to 2000 mg per 24 hr period. 20 g of fat is not required with Victrelis but it must be taken with food for maximum absorption benefit.
1838299 tn?1403496143 No, the anemia from HCV therapy is distinct from say, iron-deficient anemia. Ribavirin causes ‘hemolytic anemia’; red blood cells are destroyed more rapidly than they can be replaced by your body. This occurs naturally anyway; normally they have a lifespan of roughly 100 days, but the HCV drugs hasten this process. Other forms of anemia occur on the other end of spectrum; red cells aren’t produced rapidly enough, for instance.
Avatar f tn Is there anyone out there currently on a DAILY regimen of ribavirin AND interferon? I am a caregiver for a friend who is currently on this regimen and it's difficult to find any information on side effects etc. for a daily treatment. I n addition, he is starting bi-weekly Neupigen as well, and the side effects seems to be getting worse. Thanks in advance.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
276730 tn?1327966546 Interferon almost always causes a reduced white blood cell count and we have addressed this many times before. Ribavirin can and commonly does cause hemolytic anemia, sometimes severe but by no means untreatable, and NEITHER are any of these things an impediment to treatment if managed correctly. Now, who and what kind of doc do you have? Because it concerns me he is not already well aware of this. But get him on the same page.
Avatar f tn Hemolytic Anemia is different, it is caused by the meds you are taking. Your Doctor should treat you now, if you are as low as 9. Generally,if the HGB goes below 8 a blood transfusion is in order. Your Doctor can reduce your Ribaviran, or prescribe you a rescue med, called Procrit.
Avatar m tn Anemia limits the option to treat hepatitis C, since the ribavirin will predictably exacerbate a pre-existing anemia, and may actually result in a fall in hemoglobin that is unacceptable. As a result, patients with anemia have often not been offered treatment for hepatitis C. Anemia often complicates anti-viral therapy for hepatitis C, again more often and more severely in patients who are co-infected with HIV.
233616 tn?1312790796 Anemia is a common side effect of treatment for chronic hepatitis C virus (HCV) infection, due to red blood cell destruction (hemolytic anemia) caused by ribavirin and bone marrow suppression related to interferon. Erythropoietin (Procrit) and other erythropoiesis-stimulating agents (ESAs) that boost red blood cell production may be used to manage anemia.
Avatar n tn Riba mostly gave me really bad hemolytic anemia and a REALLY bad attitude. Oh, yeah, and the trots! I got SVR so it was worth it.
Avatar f tn When your HGB drops below 10 for medical reasons, or in people on HCV tx in response to ribavirin in their blood it called Hemolitic anemia " This is not the anemia often called iron poor blood where you can eat food with more iron or take iron supplements to raise your HGB. "(Hemolytic anemia is a condition in which there are not enough red blood cells in the blood, due to the premature destruction of red blood cells.
26471 tn?1211940121 These patients are sensitive to the antiviral and immunologic effects of interferon and ribavirin, and two previous studies have suggested that most nonresponders who responded to higher doses of interferon or peginterferon during retreatment are those with a previous partial virologic response Effect of ribavirin dosing on virologic response The starting dose of ribavirin may also play a role in enhancing virologic response.
Avatar m tn My experience (48 weeks of treatment) was that side effects varied, some would come and go, others were with me throughout. The worst for me was the hemolytic anemia. I had to have a transfusion at week 6 and took the rescue drug, Procrit, for 40 weeks. The anemia causes exhaustion, dizzyness and extreme shortness of breath. The good news is that the anemia indicates that your ribavarin dose is not too low.
Avatar m tn Compared with ribavirin, however, taribavirin is less likely to cause hemolytic anemia, a side effect that often necessitates ribavirin dose reduction or discontinuation. But taribavirin is more likely to cause diarrhea. Week 12 results from the study were presented this past April at the annual meeting of the European Association for the Study of the Liver (EASL 2008).