My eldest son, 25, has OCD-O. At 17 he became very depressed (OCD not diagnosed as yet) so went on prozac. Since then, because of various side-effects (bladder/sexual), his psychiatrist switched him to zoloft, then paxil, effexor, back to zoloft, then prozac, all the while trying to get rid of the side-effects. They helped his depression, but not his obsessive thoughts. He tried 'cognitive behavioral therapy', which helped immensely. Yoga & meditation also help.