insulin glargine action

Examples are insulin zinc suspension, protamine zinc insulin, and the insulin analogues insulin glargine and insulin detemir. The latter two insulins are now the most widely used long-acting insulins. * Biphasic insulins: mixtures of short-acting and intermediate-acting insulins in different proportions, such as 30/70, 50/50. Examples are NovoMix 30, Humulin M3, Insuman comb and Humalog Mix25.

I would continue to use insulin glargine, a recombinent insulin analogue (Lantus) without concern. This was the recommendation in the British Journal Lancet Vol 1, 374 issue 9649 p511-513 15 August 2009. The media has produced some fear based upon five studies that I have read, and used some statistical manipulation that would have failed me in "statistics one" in the eighth grade. The experimental protocols were pretty crummy.

Hi Dawn, Pizza can be tough to estimate, more because the carb content can vary so much from slice to slice and pizza to pizza. But although I'm just a mom like you, and not a doctor, it sounds like it's not just pizza causing high blood sugar. You didn't say what sort of long-lasting insulin she's on-- is it Novalin? Or Lantus/glargine? If you haven't tried Lantus (aka glargine) yet, I would strongly recommend talking to your endo about it.

She complained of polidypsia, dry mouth, weight loss. Insulinotherapy was initiated with glargine, ten units at bedtime (glycemic value before aministration was 169) after reiceiving 6 units of aspart imediately (7 pm). Next day a fasting value of 140 mg/dl. Bedtime value (2 hours postprandial ) 269. After 10 U glargine, fasting value 120 mg/dl. Glycemic variation are very important and depend on the thyroid status. What is your opnion?

I am curious as why you do not mention that Glargine(lantus) does NOT have a license for twice daily usage ,levemir has a licensce for OD and BD and has weight benefits for type 2 patients???? or are you heavily sponsored/involved with the manufactureres of glargine? I am interested.

"My GP states this is normal and will eventually pass." It appears you are experiencing well known severe sides effects of Lantus. Have you spoken with your endo about your discomfort and other options? Go here and read "before taking insulin Glargine (Lantus)" http***www.nlm.nih.gov/medlineplus/druginfo/meds/a600027.html See if this applies to you.

The doctor thinks it is too high and gave Recombinant Insulin Glargine Injection and my mother does 15 unit injection every night. But blood sugar is still like 7.3~8.3 mmol/L before meal and 9-10 mmol/L after meal. Is this often to see among diabetes type 2 patients? Can some one give me any advice about how to improve my mother's condition? Sincerely thanks.

Montefiori Medical Center (Bronx, New York) performed an in-depth study of 240 women receiveing Lantus (insulin glargine) during pregnancy. The results were published in the Journal of Reproductive Medicine, April, 2009 (4) 208-10. They found the drug to be well-tolerated and advised continuing the use of Lantus during pregnancy. PubMed has no studies whatsoever that substantiate an adverse affect on pregnancy.

Have you asked your doctors about the insulin pump. It allows you to set a basal rate of insulin using fast acting insulins (Humalog) for very specific time periods. This will allow you to adjust dosages based on your very specific needs. I have had great success using it. Prior to using the pump I also had difficult time with overnight and morning blood glucose levels. My last A1C was 5.9 it really workds!!!

Lantus (insulin Glargine) is a very SLOW release insulin, a so-called "24-hour" insulin. Because it does not rapidly alter glucose levels it is safe to use when driving. It isn't adviseable to increase the dose of Metformin. Other insulins have the tendency to rapidly (comparatively) alter levels of conscious and situational awareness. It is often prescribed together with Metformin and Glipozide. I would also hazard a guess that weight control is an issue.

There is a big difference in the action of humalog 50/50 compared to regular. You should really only change your medication with the supervision and guidance of your doctor. Please do discuss this with your doctor.

is aptly named because that is what we try to do with our insulin usage. We are trying to mimic the action of the pancreas in people who don't have diabetes. Their bodies have a low level of background insulin all the time and that's why we take our basal which lasts 24 hours (sometimes not so we split the dose). Then their bodies give off spurts of more insulin when they perceive carbs being eaten.

Humalog is a fast acting insulin. Typically it is taken before meals - up to 15 minutes before (not after) to match the amount of carbs eaten. It's duration of action is 3 - 5 hours, with most of the action in the first 2 hours. You need to work out a carb:insulin ratio (ie. how much Humalog you need to cover how much carbs/ protein). If you are going low overnight (how low?), then you need to be taking a lower dose of Humalog with your evening meal. What time do you eat dinner?

The prolonged duration of activity of insulin glargine is dependent on injection into subcutaneous tissue. Intravenous administration of the usual subcutaneous dose could result in severe hypoglycemia.

Elevated blood glucose levels are indicative of gestational diabetes, although no one seems to know exactly what causes it. Hormones in the placenta can block the action of the mother's insulin in her body; insulin resistance makes it hard for the mother's body to use insulin, and without enough insulin glucose is turned into energy because it can't leave the body. A high level of blood glucose, called hyperglycemia, requires the baby to work harder.

com If you click on the Message board for Lantus glargine insulin, it will bring you to the message board on Lantus. I'm getting ready to take my kitty to the Vet for a dental, so won't have too much more time here. I'll try and get this other link directly to Lantus message board. I give Maggie Lantus every 12 hours, The links are hard for me to figure out how to post here, but here it is: http://www.felinediabetes.com/FDMB/viewforum.php?

In view of following indicated action of insulin, Can added insulin by medicines or injected cause increase in fats depositions and greater visceral adiposity?

Cristophe, It sounds like skipping meals is working for you. And, as long as your blood sugars remain within the target range, thats great. But the insulin you are using was not really designed to be used that way. Mixtard is pre-mixed insulin containing 30% rapid-acting and 70% NPH insulin. It's maximum action is at 2-8 hours after injection. And meals should be timed to coincide with this.

I am assuming that you are referring to your menstrual cycle. For people with diabetes, it is common for blood sugar levels to rise during the premenstrual phase, due to production of hormones that oppose insulin's action. For those who don't have diabetes, the pancreas adjusts by secreting extra insulin, so blood sugar should not rise.

Insulin glargine action

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