Insulin glargine peak
Common Questions and Answers about Insulin glargine peak
lantus
One thing which startled me was that when you said Glargine insulin has a peak hour. I visit a non private hospital to do my diabetes follow up once every 4 months and sometimes these doctors are soo busy as they have so many patients to look at. Thats why i m asking help over here..thanks.
When i asked my doctor the last time, he said no way..
I would continue to use insulin glargine, a recombinent insulin analogue (Lantus) without concern. This was the recommendation in the British Journal Lancet Vol 1, 374 issue 9649 p511-513 15 August 2009. The media has produced some fear based upon five studies that I have read, and used some statistical manipulation that would have failed me in "statistics one" in the eighth grade. The experimental protocols were pretty crummy.
Examples are insulin zinc suspension, protamine zinc insulin, and the insulin analogues insulin glargine and insulin detemir. The latter two insulins are now the most widely used long-acting insulins.
* Biphasic insulins: mixtures of short-acting and intermediate-acting insulins in different proportions, such as 30/70, 50/50. Examples are NovoMix 30, Humulin M3, Insuman comb and Humalog Mix25.
Hi Dawn,
Pizza can be tough to estimate, more because the carb content can vary so much from slice to slice and pizza to pizza. But although I'm just a mom like you, and not a doctor, it sounds like it's not just pizza causing high blood sugar.
You didn't say what sort of long-lasting insulin she's on-- is it Novalin? Or Lantus/glargine? If you haven't tried Lantus (aka glargine) yet, I would strongly recommend talking to your endo about it.
She complained of polidypsia, dry mouth, weight loss. Insulinotherapy was initiated with glargine, ten units at bedtime (glycemic value before aministration was 169) after reiceiving 6 units of aspart imediately (7 pm). Next day a fasting value of 140 mg/dl. Bedtime value (2 hours postprandial ) 269. After 10 U glargine, fasting value 120 mg/dl. Glycemic variation are very important and depend on the thyroid status.
What is your opnion?
I am curious as why you do not mention that Glargine(lantus) does NOT have a license for twice daily usage ,levemir has a licensce for OD and BD and has weight benefits for type 2 patients???? or are you heavily sponsored/involved with the manufactureres of glargine? I am interested.
The doctor thinks it is too high and gave Recombinant Insulin Glargine Injection and my mother does 15 unit injection every night. But blood sugar is still like 7.3~8.3 mmol/L before meal and 9-10 mmol/L after meal.
Is this often to see among diabetes type 2 patients?
Can some one give me any advice about how to improve my mother's condition?
Sincerely thanks.
Montefiori Medical Center (Bronx, New York) performed an in-depth study of 240 women receiveing Lantus (insulin glargine) during pregnancy. The results were published in the Journal of Reproductive Medicine, April, 2009 (4) 208-10. They found the drug to be well-tolerated and advised continuing the use of Lantus during pregnancy. PubMed has no studies whatsoever that substantiate an adverse affect on pregnancy.
t make sense why an A1c would be that high if he rarely shows high blood sugars on his monitors. Is he testing regularly? Is he on Lantus/glargine? (That really helped stabilize my daughter.)
Let us know, and good luck with this challenge.
Have you asked your doctors about the insulin pump. It allows you to set a basal rate of insulin using fast acting insulins (Humalog) for very specific time periods. This will allow you to adjust dosages based on your very specific needs. I have had great success using it. Prior to using the pump I also had difficult time with overnight and morning blood glucose levels. My last A1C was 5.9 it really workds!!!
Lantus (insulin Glargine) is a very SLOW release insulin, a so-called "24-hour" insulin. Because it does not rapidly alter glucose levels it is safe to use when driving. It isn't adviseable to increase the dose of Metformin. Other insulins have the tendency to rapidly (comparatively) alter levels of conscious and situational awareness. It is often prescribed together with Metformin and Glipozide. I would also hazard a guess that weight control is an issue.
You may want to check on the 6 hour duration, many insulin experts will recommend you use 4 hours as the length of the insulin duration. So your blood sugar rises because of the immediate release into your system of the carbs in the ice cream, flooding your bloodstream with carbs, and the insulin takes a bit to get working.
I, like you, have noticed a definite peak between 4-5 hours after taking the Lantus, so taking it in the morning makes this peak mean that i require less morning quick-acting insulin to cover my breakfast. Like you, also, I noticed elevated morning sugars, and I have fixed this problem by doing the spilt dose. so some insulin is working well through the night. In my case, I take my larger dose (2/3 of my total) in the morning, and I take 1/3 of my total daily dose at bedtime.
between bedtime and breakfast I am having a drop in BGs of around 10-13 mmols. and then in the mornings, after breakfast BGs shoot up, so my normal carb-insulin ratio doesnt work well.
I cannot understand why this overnight drop is happening, which is becoming scary. I tested BGs during the night and there seems to be a drop of 2 mmol/hour. I am forced to go to bed with readings around 20, so that I will wake up with 7-8.
I also found some books that calculated the amount of insulin to use and gave the peak arc and life span of each type of insulin. My most recent one was Dr. Bernstein's - although I now dispute his protein diet as red meat does horrible things to my gut. I find that humalog is nifty but that regular did a better job on the longer-digesting proteins and fats (unless you use Lantus as the long-acting insulin with humalog). Hope that helps.
m I on too much medication as my blood sugar are still not under control, they are still going up and down just like a mountain peak, How much insulin will I need to be able to control my sugar and will I come off the metformin when that happens, I am also a bi-polar manic depressive patient and I am very depressed at thsi point due to the fact of the new use of insulin and things just don;t seem to be going in the right direction I am very confused, I have considered going in to see my internis
s another good tool for figuring out how much insulin to take when you eat. If your insulin is peaking at dinnertime, that means it's at it's strongest level and then it's downhill from there. So even if it's low before you eat, there is probably not enough left in you to take care of what you are eating for dinner. You may have to take a little less regular insulin at dinner, but you will probably have to take some.
MY DOCTOR PRESCRIBED LANTUS INSULIN TO REPLACE THE HUMULIN L INSULIN THAT I HAD TAKEN FOR SEVERAL YEARS. I HAVE NOTICED THAT WHEN I TAKE THE LANTUS INSULIN PRESCRIBED DOSAGE(S) THAT APPROXIMATELY 15-30 MINUTES LATER I START TO SWEAT PROFUSELY. IS THIS A NORMAL REACTION TO THE LANTUS INSULIN? I VOICED MY CONCERNS TO MY DOCTOR AND HE HAD NO COMMENT. I AM ALSO TAKING SEVERAL DOSES OF HUMULIN R AND HAVE GAINED WEIGHT SINCE I STARTED TAKING THE LANTUS. PLEASE ADVISE. THANK YOU.
At this point, the adjustment to insulin doses is generally done EACH day, according to when the peak action of whatever type of insulin the diabetic person is taking. So if your glucose levels have not improved after several days on insulin with glucose readings still running between 400-600, I would certainly call my physician and tell him or her that this is not acceptable diabetes management in your opinion and ask him or her what changes to make.
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