http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500253.html
and did find some info on skin changes ..
"Less common or rare
Depression of the skin at place of injection; thickening of the skin at place of injection; ..." This doesn't mention cellulite directly, but it sounds similar.
The site also has a clear caution to discuss these or any other changes with your doc.
Insulinotherapy was initiated with glargine, ten units at bedtime (glycemic value before aministration was 169) after reiceiving 6 units of aspart imediately (7 pm). Next day a fasting value of 140 mg/dl. Bedtime value (2 hours postprandial ) 269. After 10 U glargine, fasting value 120 mg/dl. Glycemic variation are very important and depend on the thyroid status.
What is your opnion? Is this a temporary glycemic instability, type 2 or type 1 diabetes?
Examples are insulin zinc suspension, protamine zinc insulin, and the insulin analogues insulin glargine and insulin detemir. The latter two insulins are now the most widely used long-acting insulins.
* Biphasic insulins: mixtures of short-acting and intermediate-acting insulins in different proportions, such as 30/70, 50/50. Examples are NovoMix 30, Humulin M3, Insuman comb and Humalog Mix25.
re seeing is the delay between the time you inject insulin and the time it starts working, typically about 15-20 minutes. The graph of the effectiveness starts low, rises fairly quickly after that 15-20 minutes to that 2 hour peak, then then gradually tails off. You may want to check on the 6 hour duration, many insulin experts will recommend you use 4 hours as the length of the insulin duration.
Your doctor can advise you as to how the Lantus is affecting you, and how to adjust your food, and time you take the insulin. You might also want to ask about the insulin pump, Which does the same as the Lantus. It gives you a base line of insulin and you just dose your self when you eat according to the amount of carbohydrates you eat.
First of all, yes many people take Lantus in the morning instead of the evening for just that reason.
However the switch is a pretty complicated one. I would suggest that it be accomplished with your Dr. but the Vol is wrong in that Lantus does not have a peak. It does have a peak at about 4-6 hours but it is not a large peak. This peak does effect many users in the middle of the night.
The easiest suggestion is to make sure that you test at dinner.
Hi again Steveman,
A few thoughts come to mind -- even tho' you're a teen ;-)
Often our summer schedules are different from school-year schedules and it's reasonable to expect to make changes in our diabetes management, too. I'm not sure which long-acting insulin you're taking, but it sounds as tho' it's not Lantus -- one of the newer insulins that doesn't *have* a real peak and lasts about 24 hours.
I also found some books that calculated the amount of insulin to use and gave the peak arc and life span of each type of insulin. My most recent one was Dr. Bernstein's - although I now dispute his protein diet as red meat does horrible things to my gut. I find that humalog is nifty but that regular did a better job on the longer-digesting proteins and fats (unless you use Lantus as the long-acting insulin with humalog). Hope that helps.
MY DOCTOR PRESCRIBED LANTUS INSULIN TO REPLACE THE HUMULIN L INSULIN THAT I HAD TAKEN FOR SEVERAL YEARS. I HAVE NOTICED THAT WHEN I TAKE THE LANTUS INSULIN PRESCRIBED DOSAGE(S) THAT APPROXIMATELY 15-30 MINUTES LATER I START TO SWEAT PROFUSELY. IS THIS A NORMAL REACTION TO THE LANTUS INSULIN? I VOICED MY CONCERNS TO MY DOCTOR AND HE HAD NO COMMENT. I AM ALSO TAKING SEVERAL DOSES OF HUMULIN R AND HAVE GAINED WEIGHT SINCE I STARTED TAKING THE LANTUS. PLEASE ADVISE. THANK YOU.
The reality is that when taking a 24-hour insulin, you cannot just make a 12-hour change in injection time all at once since you will either be without a base insulin working at all for 12 hours if you wait 36 hours to inject the new dose or you would be overdosed by half the amount of your total dose for 12 hours if you took the next injection 12 hours after the last injection in order to change your timing. So it needs to be done 1 unit at a time in order to not rock the boat too much.
m I on too much medication as my blood sugar are still not under control, they are still going up and down just like a mountain peak, How much insulin will I need to be able to control my sugar and will I come off the metformin when that happens, I am also a bi-polar manic depressive patient and I am very depressed at thsi point due to the fact of the new use of insulin and things just don;t seem to be going in the right direction I am very confused, I have considered going in to see my internis
Diabetes is heart-wrenching for parents. As you've noted, it can be a dangerously fine line between good-control and dropping too low.
None of us here is a medical doctor, but all of us have extensive personal experience as a diabetic or caregiver. It seems to me that you should call your daughter's doctor right away to discuss this situation. And, I'd encourage you to get comfy calling the doc whenever your "mental alarms" start going off.
At this point, the adjustment to insulin doses is generally done EACH day, according to when the peak action of whatever type of insulin the diabetic person is taking. So if your glucose levels have not improved after several days on insulin with glucose readings still running between 400-600, I would certainly call my physician and tell him or her that this is not acceptable diabetes management in your opinion and ask him or her what changes to make.
between bedtime and breakfast I am having a drop in BGs of around 10-13 mmols. and then in the mornings, after breakfast BGs shoot up, so my normal carb-insulin ratio doesnt work well.
I cannot understand why this overnight drop is happening, which is becoming scary. I tested BGs during the night and there seems to be a drop of 2 mmol/hour. I am forced to go to bed with readings around 20, so that I will wake up with 7-8.
Neither of these insulins are types that start to act immediately, and the ideal is to time the meal so that he is doing his primary digestion at the same time that the insulin is peaking. This sort of timing may be different for different people, depending on how quickly their bodies absorb the insulin and how quickly they digest their foods.
I have recently changed to new insulin. I am now taking Levemir in the morning and at night taking Apidra. Since I have changed to this insulin my blood sugar is going upby alot. I was at 176 this morning and within a few hours it was at 296. This has never happened before and I have not changed anything in my eating. Why is it going up so much and how can I make this stop?
I agree with you that slow digestion would probably cause a low at first, followed by high sugars hours later. I have noticed that if I eat a meal that is heavy in fats (fats slow digestion time of the carbs in a meal), such as french fries (NO, I do NOT make a habit of eating stuff like this!), I have to wait until about a half hour AFTER I eat to take my Novalog so the insulin doesn't peak before the carbs digest.
Hello, Sherry. I'm so glad that you are taking the opportunity to learn as much as you can about how to manage diabetes, that's not something that everyone in your position would do.
The first step to learn more is to contact her nurse practioner to get hooked up with a dietician, and in particular one that specializes in diabetes. It is important to understand nutrition and how it relates to controlling blood sugars.
According to our doctor and the insulin manufactures insulin should be taken at the same time every day- Especially if it is NPH or Lantus. These long lasting insulin peak in a certain amount of time, then the blood sugars start to rise.
We solved this problem by myself or my husband getting up, checking her blood and give her shot while she was sleeping or she would get up take her shot and go back to bed. Then we got her the insulin infusion pump.
s hard to say which one they were talking about. The benefits of these new insulins is the time that elapses before the insulin takes effect. Most fact acting insulins don't take effect for at least 15 minutes, which has the potential to cause the blood sugars to temporarily go higher than they need to. The new insulins are supposed to act sooner, so getting on one of those trials could be a very good thing.
Recommended
injury etc
Her insulin brand was changed from Novomix (mix of 30% insulin aspart and 70% protamine crystallised 