She very nearly needed knee replacements on both sides, and was an big opioid
user. Nothing controlled her pain, despite sulfasalazine, methotrexate, plaquenil, and heavy doses of oxycontin for pain, and a lot of illegal (bad for the liver...methotrexate is bad enough on the poor organ) tylenol. A few years ago, mum went to see a different rheumatologist and now she's saved!! She takes Enbrel now and it literally saved her life. Her arthritis is so much better now...