They were associated with the nausea and as soon as I got the nausea under control with the Zofran, the
swollen ankles disappeared. Then I had 2 more episodes of
swollen ankles, one less serious episode during the month following the end of treatment and one episode 2 months after the end of treatment. That last episode was pretty bad, very swollen ankles, feet, and legs up to my knees. That went away after about 3-4 weeks. I know they were all med related. I had no real cardiac problems.