Ribavirin therapy
Common Questions and Answers about Ribavirin therapy
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Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking Ribavirin therapy. At least two reliable forms of effective contraception must be utilized during treatment and during the 6 month post treatment follow-up period
http://www.drugs.com/pro/ribavirin.
After researching Tramadol last week and seeing its sx I was wondering if it was contributing to the hallucinations I was having with the interferon and ribavirin. I asked the doctor if there was any other pain med I could take after doing the research and scaring myself silly and was told no. I tried weaning off of the Tramadol, but the pain is too much to bear along with the sx of the HCV therapy, so started taking it again.
24 Because the duration of BOC therapy (24 to 44 weeks) is longer than the duration of TVR therapy (12 weeks), the frequency of anemia is likely to be greater in BOC-containing regimens, leading to more RBV dose reductions and consideration of erythropoietin use. However, the potential benefits of erythropoietin must be weighed against its potential side effects, the fact that its use in HCV therapy is not approved by the FDA, and its considerable cost.
https://www.aasld.
Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking ribavirin therapy. At least two reliable forms of effective contraception must be utilized during treatment and during the 6 month post treatment follow-up period."
"5.1 Pregnancy COPEGUS may cause birth defects and/or death of the exposed fetus.
These effects occurred at doses as low as one twentieth of the recommended human dose of ribavirin. Ribavirin therapy should not be started until a report of a negative pregnancy test has been obtained immediately prior to planned initiation of therapy [see BOXED WARNING, CONTRAINDICATIONS (4), USE IN SPECIFIC POPULATIONS (8.1), and PATIENT COUNSELING INFORMATION (17.2)].
USE IN SPECIFIC POPULATIONS
Pregnancy
Pregnancy Category X
[See CONTRAINDICATIONS (4), WARNINGS AND PRECAUTIONS (5.
Patients should be instructed to use at least two forms of effective contraception during treatment and for 6 months after treatment has been stopped. Pregnancy testing should occur monthly during Ribavirin therapy and for 6 months after therapy has stopped [see Boxed Warning, Contraindications (4), Use in Specific Populations (8.1), and Patient Counseling Information (17)].
http://www.drugs.com/pro/ribavirin.
The safety assessment of SOVALDI is based on pooled Phase 3 clinical trial data (both controlled and uncontrolled) including 650 subjects who received SOVALDI + ribavirin (RBV) combination therapy for 12 weeks, 98 subjects who received SOVALDI + ribavirin combination therapy for 16 weeks, 250 subjects who received SOVALDI + ribavirin combination therapy for 24 weeks, 327 subjects who received SOVALDI + peginterferon (Peg-IFN) alfa + ribavirin combination therapy for 12 weeks, 243 subjects who
Fifty patients with chronic hepatitis C virus (HCV) infection genotype 1 were randomly assigned to groups that were given peginterferon alpha-2a, with or without ribavirin, for 4 weeks; all patients then received an additional 44 weeks of combination therapy. First- and second-phase viral kinetics were evaluated.
Protected sex must be practiced by males taking Ribavirin therapy with partners that may become or "are "pregnant . You doctor should have advised you of this.
Please talk to your doctor and I advise to phone the " Ribavirin Pregnacy Rregistry" office (the number is linked below)
Best to you..
Will
http://www.drugs.com/pregnancy/ribavirin.html
Ribavirin Pregnancy Warnings
Ribavirin has been assigned to pregnancy category X by the FDA.
HCV viral breakthrough is an ongoing possibility during the pegylated interferon/ribavirin continuation phase after triple therapy with telaprevir (Incivek or Incivek or Incivo), especially for difficult-to-treat patients, researchers reported this week at the Digestive Disease Week conference (DDW 2013) in Orlando.
Extreme care must be taken to avoid pregnancy during therapy and for 6 months after completion of therapy in both female patients and in female partners of male patients who are taking Ribavirin therapy. At least two reliable forms of effective contraception must be utilized during treatment and during the 6 month post treatment follow-up period
http://www.drugs.com/pro/ribavirin.
I am 30 years old and have finished Peg Interferon and Ribavirin treatment for Hepatitis C Genotype 2(24 weeks) about 6 months ago. I have had no virus detectable since about 8 weeks in the treatment. I want to become pregnant now. What are the risk factors?
If severe adverse reactions or laboratory abnormalities develop during combination Ribavirin tablets/peginterferon alfa-2a therapy, the dose should be modified or discontinued, if appropriate, until the adverse reactions abate or decrease in severity. If intolerance persists after dose adjustment, Ribavirin tablets/peginterferon alfa-2a therapy should be discontinued.
pegylated interferon and ribavirin PLUS either boceprevir or telaprevir
You will be given a treatment regimen based in large part on your genotype. Genotype refers to the "strain" of hepatitis C virus that a person has. There are six genotypes. In the United States, genotype 1 is the most common, followed by genotype 2 and 3.
People with genotype 1 generally are given triple therapy.
People with genotype 2 and 3 are given dual therapy.
http://www.hepatitis.va.
I recently completed treatment with peginterferon alfa-2b plus ribavirin back in November 2009 and did not respond to the initial therapy. I had minimal side effects and tolerated the medication fairly good. Now I am eating healthy and try to exercise everyday.
I have read about telaprevir therapy and its availably in roughly three years but till then what kind of supplements besides milk thistle has anyone been taking to help keep HVC at bay?
Telaprevir is not as likely as boceprevir to cause anemia -- its notable side effect is skin rash -- but anemia rates among people on telaprevir triple therapy were higher than those for patients taking pegylated interferon/ribavirin dual therapy.
Results
Among treatment-naive patients, half of those taking telaprevir triple therapy had a ribavirin dose reduction compared with 18% of those on pegylated interferon/ribavirin alone.
The clinical implications of these findings are that genotype 1 HCV–infected patients who achieve an RVR with peginterferon/ribavirin treatment might be well served with only 24 vs 48 weeks of therapy, especially if they are younger in age and have baseline HCV RNA 2 log reduction in HCV RNA at Week 12, alternative management strategies should be considered.
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