daily infergen and ribavirin therapy

Is there anyone out there currently on a DAILY regimen of ribavirin AND interferon? I am a caregiver for a friend who is currently on this regimen and it's difficult to find any information on side effects etc. for a daily treatment. I n addition, he is starting bi-weekly Neupigen as well, and the side effects seems to be getting worse. Thanks in advance.

Hi Mercyfish, My husband was on daily injections of Infergen and 1400 mg of Ribavirin in 2010. This was a very, very difficult treatment, probably the most difficult of the three treatments that he has undergone. I am sorry that you are having to experience daily Infergen, especially since you have the responsibility of three children at home as well. My husband made it through 12 weeks of this difficult treatment. It didn't work for him.

I know Infergen can be used in different ways. When my husband took Infergen in 2010 it was a daily injection of Infergen and 1400 mg/day of Ribavirin. My question is I wonder why his doctor would put him through the grueling "Consensus Interferon" or Infergen treatment rather than go to triple tx. I guess knowing the OP's genotype or some other information may answer that question.

t know phenotype, but he was a partial responder in two previous therapies (1st SOC, and 2nd daily infergen injections - infergen is another variety of interferon - and 1400 mg. ribavirin) It is my husband who is treating, not me.

[33] In the second study, patients with a previous nonresponse to standard interferon and ribavirin were retreated with peginterferon alfa and ribavirin.[34] Overall, 28% of patients in this study achieved an SVR. However, 75% of these patients had a partial virologic response during the initial course of treatment.

I would have like to try the daily shot of infergen and the pills of alinia but it was not ment to be. I will now go and do all the things that I have wanted and enjoy what is left.

Interferon and Ribavirin, Pegasys and Ribavirin and again Interferon and Ribavirin before he decided to put me on the more powerful, and in my opinion, the more unpredictable Infergen...

ve had previous experience with Infergen on more than one occasion. I was on maximum dose of Infergen daily for a good chunk of time. Unfortunately, for me, I did not clear, but I have a very resistant strain on the Hep because I've treated with everything and have not been able to clear. So, please don't let my experience discourage you any.

ll switch you I suspect he may be talking about infergen and ribavirin. Infergen is reserved for people who have failed prior treatment. I failed pegintron and ribavirin 8 years ago and am retreating with infergen now. otherwise, if he meant protease inhibitors, those are not yet approved by the fda the only way to get it is through a clinical trial right now.

Is retreatment with Infergen realistic after failing one course of Pegintron/Ribavirin AND one very long course (80 weeks) of Pegasys/Ribavirin? Should I wait for the protease inhibitors? One month post treatment with Pegasys 180mcg and Ribavirin 1400mg (increased from 1200 because I kept bouncing between positive and negative), my viral load popped back up to 2.5 million. After Pegintron, it took 6 months to get up to 2.2 million (that was when I tried Pegasys/Ribavirin).

1% in the 15 mcg arm -- Patients maintaining full dose of INFERGEN/RBV therapy had SVRs of 7% and 17% for the 9 mcg and 15 mcg arms respectively"

gov/pubmed/1695539?dopt=Abstract), (and assuming a drop in VL no doubt) Finally ribavirin metabolism involves several cytochromes. but primarily 2D6 and 3a. Here I would focus on the cyp 3a, because the telaprevir or boceprevir are also reliant on this cytochrome. Meaning this cytochrome will have plenty to do while you are treating. My SUGGESTIONS to the patients, and the high risk or late stage patients especially would be 1.

At week 16 pegasys + riba my viral load was 94,000 - killed the last hope - obviously I was not responding to this therapy. Last week switched to daily infergen plus riba. First two days on infergen were TOTAL HELL - very high fever, chills, and pain allover my body. Couldn't sleep at night at all due to the pain. But after two days - I am back to feeling normal again. The only problem - my hair loss got much worse. In three weeks will have my viral load labs done...

Then in late September 2009 I was switched from pegasys to daily infergen and continued with the same dose of ribavirin. Undetectable since week 8 on infergen. I asked the doc about procrit, he said they prefer to avoid it... My concern - if I stop ribavirin now, even if it's only for a week, will it lower my chances for SVR? If you had a similar experience with anemia and stopping riba for some time during tx, and still achieving SVR? I am 1b, 170 lbs, female.

I would like some input from anyone on daily Infergen. I am contemplating this tx. and at the same time have been offerred an excellent job.I only work weekends at this time and the new job would be 5 days a week. I do not want to commit to a new more demanding schedule and then not be able to follow through because of side effects. Can I get some honest input from some of you guys who are doing this tx or who have done it in the past. I would so much appreciate your help.

I agree with pro -- I don't think the success rates with infergen are all that great, and the PI's give everyone a much better chance at success.

I don't know how she did it either nygirl. Here I was bellyaching on my tx and she was going through pure hell, getting transfused, taking Procrit and Neup plus daily Infergen shots. I couldn't have done it. I have to work to keep my health insurance and no way on earth I could have worked and that's what Deb says too. At least with pegylated interferon and ribavirin most of us can work.

Although I wish it was otherwise and I really don't know for sure, I don't think you can ignore the initial 10 weeks and consider it a do-over. It's great that you are responding so much better to the infergen and hopefully you will become und soon and go on to svr. If your vl was 144 iu/ml at week 12, you may have become und within days of that so you might be considered close to EVR rather then RVR would be my guess. http://www.natap.org/2010/HCV/080610_02.

1% in the 15 mcg arm Patients maintaining full dose of INFERGEN/RBV therapy had SVRs of 7% and 17% for the 9 mcg and 15 mcg arms respectively Patients demonstrating partial response (>2-log drop) with previous treatment and low fibrosis scores F0-F3 had SVRs of 10.7% and 31.6% for the 9 mcg and 15 mcg arms” http://www.ncbi.nlm.nih.gov/pubmed/19291790?

s called Infergen (concensus interferon) and it consists of daily shots of Interferon Alfacon-l plus weight based ribavirin. Very tough treatment but there are success stories for those who have undergone treatment with Infergen.

My current doctor would like to retreat with Infergen and Ribavirin, with the belief that the HCV virus has developed some form of immunity to the pegylated interferon. Studies show, however, that only 31% of pegylated interferon treated relapsers had non-detectable levels of HCVRNA after 12 weeks of Infergen/Ribavirin treatment. New studies show that 36-75% of pegylated interferon treated relapsers had non-detectable levels of HCVRNA after 12 weeks of pegylated interferon retreatment.

We listed the toll free numbers for assistance with hepc medications but if your father was on interferon and ribavirin previously and it did not help there really isn't anything else out yet that will cure hepatitic c. Three Rivers Pharmaceuticals is the manufacturer of Infergen and Ribasphere. Infergen is consensus interferon and is administered as a daily injection. The side effects can be very difficult and the rate of cure is no greater.

The trial ended and my doctor decided to take away the Intron A and put me on Infergen at 15mcg daily. Unfortunately, 12 weeks later my viral load had gone up to 60,000 and I didn't miss any injections. It is possible that you have built some resistance to the interferon. Some people actually get to undetected and then have the viral load come back before treatment ends. this is called breakthrough. I hope you can figure out what happened and get back on track.

Daily infergen and ribavirin therapy

Common Questions and Answers about Daily infergen and ribavirin therapy

rebetol