Valtrex renal dosing
Common Questions and Answers about Valtrex renal dosing
valtrex
Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
However, it is well documented that valtrex and acyclovir perform very similarly. Valtrex is actually converted into acyclovir by the liver, so essentially, the two drugs act the same way in the body to suppress the virus. If acyclovir improves your quality of life, I would stick with it and explain the similarities to your partner - they are well documented and I expect you can find information in scholarly journals that supports the suppressive activity of acyclovir.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
Liroff,
I have been on several different antibiotics over the course of the past month (Doxycycline 11 days, Metronidazole 7days, and I am currently on valtrex). I have finished all of the other medications, but I am currently on Valtrex twice a day for another five days. Recently, I have not be urinating as much as a usually do.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
I get cold sores and was recently prescribed valtrex for outbreaks. Trouble is, it isn't always obvious that I'm going to have an outbreak. I'd rather be safe than sorry - but don't want to take valtrex too often if it isn't safe.
Would it be a problem if I took the one day 2,000 mg maybe twice per month when I thought an outbreak might be coming on?
Prior to that I was taking Valtrex (500 mg) once daily for 18 months. For the past few months I have noticed that my blood pressure is elevated (140s-160s sys over 80s-90s dia). Could the use of acyclovir be causing this?
Any insight is appreciated.
I am trying to figure out how to minimize outbreaks (I seem to get one after every infusion) I am currently on generic valtrex which I had only been taking for outbreaks. I looked up the standard dosing for prevention of outbreaks but that doesnt seem to keep them at bay either. I cant stop getting th remicade so are there any suggestions as to what I can do?
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
What if i have an outbreak while im on it? Do i start taking Valtrex, 3 times a day and then continue my 1 a day after 7 days of the 3 a day? Im just a wreck about all this, it makes you so paranoid!
if I may just have vaginal irritation from the constant moisture and contact with blood? Valtrex is category B and since.I have it on hand should I increase my dosing to head this off, I work for a doctor and we usually prescribe 5qd for 5/days..... any advice?
I have read that if a couple where the male has HSV-2 and the female is both HSV-1 and HSV-2 negative does nothing more than avoid sexual contact during outbreaks, the female has an 8% chance of contracting HSV-2 genitally in any given year. However, if the male takes 500 mg of Valtrex daily, that percentage is reduced to about 4%.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
Since then I have had 2 minor outbreaks, both on my waist near the navel. I currently use Valtrex when I feel an outbreak coming on and it seems to suppress the symptoms.
I'm recently in a new relationship and need to discuss with my new partner before we become sexually active, but before I do I had a couple of questions. Since my outbreaks are on the waist a condom will obviously not cover that area.
But regarding this Vit D , should i need to take along with calcium supllements Or no need? I have renal stones of 0.5mm. Does this have any effect on this?
ve only had one partner so, yes, it only takes once!). Anyway, I keep reading that for suppression valtrex is once a day and acyclovir is 400 mg twice a day. My dr prescriped 800mg once a day. What's the difference, why would someone take acyclovir twice a day when they could just take it once? Is there an advantage to taking it twice a day?
My second question is that when I am having an outbreak should I increase the dosage?
I am HSV-2 positive and my girlfriend stopped using condoms last week. Our relationship is still relatively new (about 8 months), so we're still having sex at least 2 or 3 times per day. I am taking 500 mg of Valtrex daily, and I know that's supposed to reduce risk of transmission by about 48% down to 4-5% per year. And this is supposedly more protection than a condom offers (around 40% reduced risk, I believe).
My 29 year old daughter had a severe and frightening reaction to Valtrex. She had cold sores and began taking 500 mg Valtrex, per script. She took one in the am and one in the pm for five days, and as adverse effects appeared, she cut back to one in the pm for four more days. She progressively became psychotic, experiencing altered states of consciousness, panic attacks, uncontrollable crying, tremors, and extreme fear. Blurred vision and the inability to focus were also taking place.
If you are stage 3 you can take any analgesic within dosing limits. Your liver function has not been altered by your liver disease yet. If you become stage 4 (cirrhosis) then you will have to modify what drugs you can take because the liver is no longer able to process drugs in a normal manner.
Tramadol is an synthetic opiate and should not be taken for "mild" pain.
Call your local pharmacist. We at MedHelp are not allowed to give out dosing instructions. Your pharmacist will be able to tell you exactly how to dose the medications. If your regular pharmacy is closed on Sunday, call any pharmacist availabe at your local grocery store or drug store such as Walgreens, CVS, or RiteAid.
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