Ribavirin weight based dosing

Common Questions and Answers about Ribavirin weight based dosing

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1476285 tn?1287341384 Hi I am curious if anyone has found a chart or info on how much interferon, ribavirin and telaprevir a person should take based on their weight. Maybe some of these are not even weight based altho it sure seems like a 100# person would not require as much of any of these as a 300# person but I don't know. If anyone has a link to this or a chart or any info, I'm just curious to know.
1747881 tn?1546179478 I am in a trial that will be comparing ribavirin dosing, weight based compared to concentration controlled based on AUC 0-12 after first dose. http://clinicaltrials.gov/ct2/show/NCT01097395?
Avatar f tn I an also Genotype 2. Have your doc look at weight based dosing and stats for SVR using this protocol. Once mine did I,was bumped up to 1200. He also recommended that I take an AD as he has had patients who at a higher dose experienced depression and riba rage.
Avatar m tn I think your friend could handle the potential fatigue of a higher-dose riba if it meant kicking viral a$$. Weight-based dosing is fine, but your friend has the benefit of "lessons learned" from past treatment. Bringing the riba dosage down after 24 weeks *if necessary* is possible when the dosage is 1200 at a weight of 115 pounds. And I'd be willing to kick in with procrit maintenance to keep riba at higher levels. Alinia and SAMe for good measure.....
223152 tn?1346981971 If I were treating, I personally would ask my doctor about pre-dosing ribavirin. At the same time........I wouldn't worry too much if pre-dosing is an option that's not available to someone. It's another theory that people discuss and perhaps as people continue to discuss it and ask their docs about it, it will be considered more but it's not common. The odds of SVR in all the trials are not based on pre-dosing added into the mix.
364323 tn?1221856766 A couple of other ribavirn factoids from Clinical Care Options -- weight based ribavirin is 13.3mg/kg @ day high dosed weight based ribavirin is 15.
135456 tn?1301441224 a randomized trial.Hepatology. 2007 Oct;46(4):971-81. PMID: 17894303 HgB decline seems a reasonable proxy for concentration, but I've never seen that documented. Testing for effective drug concentration is supposed to happen as part of the early phases of testing so I suppose at this stage the main impetus for such a test would be data showing that patients with similar dosages exhibit a wide range of concentrations. BTW the 14.
135456 tn?1301441224 By the way I am 6 ft 200lbs and feel that the 1,200 mg's he prescribed may be to low . What is the weight based formula I shoud be receiving?
Avatar n tn Patients weighing < 65 kg received 800 mg/day; patients 65 to < 85 kg received 1000 mg/day; patients 85 to < 105 kg received 1200 mg/day; and patients 105-125 kg received 1400 mg/day.
Avatar f tn A's recommendations to be on weight-based ribavirin. Lastly, ask how often you would be able to see him personally or how you would be able to contact him (email, phone, etc) in the event you had questions not fully answered by let's say his NP, if that is how the office is set up. (BTW email is great if the doctor uses it so always ask!
Avatar f tn Are there studies showing that weight based dosing is more effective? Does anybody have any links to the correct dosing charts, it doesn't appear on the drug insert.
577132 tn?1314270126 They suggest that the larger question of whether true weight-based dosing of ribavirin is superior to the currently approved standard dosing schemes still awaits head-to-head studies to answer. "At the minimum," they conclude, "the traditional notion that ribavirin dosage should be fixed has now been sidelined by the idea that we should tailor ribavirin dosing to our patients.
Avatar f tn There is a ribavirin wt based dosing schedule in table 1 and 2, just follow the link http://www.gene.com/gene/products/information/pegasys/pdf/copegus_pi.
Avatar m tn If every person absorbs ribavirin at different levels based on many more factors then their weight (kidney function for example) then weight based dosing doesn't make a lot of sense. If anemia is more then a crude indicator of riba absorption then why do a good amount of people still svr without becoming anemic, and why not just reduce riba when a person becomes anemic rather then give them procrit to keep the dose up.
Avatar n tn Towards the final increases occurred within a week or so to reach the final weight-based goal for me. Needless to say it did cause a precipitous drop in my Hgb which took a couple of weeks to recover from because they did not adjust my Procrit dosage quick enough, I think in large part because of the high dosage I was reaching.
Avatar m tn The initial ribavirin dose was individualized and calculated from a pharmacokinetic formula based mainly on renal function. Ribavirin plasma concentrations were monitored, and the dose was adjusted to reach the target concentration. Hemoglobin was monitored, and patients were treated with erythropoietin and blood transfusions when indicated. After dose adjustments, the mean dose of ribavirin was 2,540 mg/day (range, 1,600-3,600) at week 24.
Avatar f tn Participants received pegylated interferon alfa-2b (PegIntron) plus 600-1400 mg/day weight-adjusted ribavirin for a lead-in period of 4 weeks, then added 800 mg boceprevir 3-times-daily for 24 or 44 weeks, depending on HCV RNA levels at week 8. Baseline hemoglobin levels were 12-15 g/dL for women or 13-15 g/dL for men.
Avatar f tn when i started tx, i weighed 167 pounds, so my doctor prescribed 1200mg of ribavirin. now i have lost weight down to 142 pounds. should i dose reduce? i have been really sick from the ribavirin. i only have 7 more shots to go out of 48 (genotype 1a, high viral load, had it 18 years). should i just suck it up and finish at 1200 or reduce? the anemia has gotten pretty bad, and i've been miserable.
158241 tn?1237723123 i think the only other thing it says is that weight is the only other thing that affects concentration in the body. therefore weight based dosing. veeeeery iiiinteresting anything to add?
9648 tn?1290094807 I'd be checking if your NP is going by a flat dosage ribavirin chart or a weight-based dosage (WBD) ribavirin chart. For Schering-Plough and at that weight, I'm thinking you'd be better off at 1000mg of Riba. That's my humble opinion on it. An article on the differences in results between FD and WBD, just in case that's what she's going by. http://www.medscape.com/viewarticle/563799 As long as you can handle it .. and the earlier the better...
119874 tn?1189759429 There was also a study published no too long ago tht favorably compared higher weight based riba dosing to lower WB riba dosing. And like Beagle says, always grab a handful of nuts when you take you're riba.
427265 tn?1444080036 Even though you are being dosed by weight, not everyone absorbs ribavirin the same way even at the same weight.
Avatar f tn If your nurse gave you the option for weight based, then personally I'd call her and switch to weight based now, assuming you're handling the side effects relatively OK and your hemoglobin isn't tanking too bad. As to "borderline", I believe 165 is borderline between 1000 and 1200 mg/day on one weight based scheme, but I'll let other confirm as it's been awhile.
29837 tn?1414538248 The double dosing will consist of double Pegasys and the standard, torturous Ribavirin. I would like to know if anyone has undergone this double dosing regiment. If so, how was it? Did you eat and sleep normally? Were you prone to lashing out at your friends? Did you have a hard time breathing? Were you extremely depressed? Was the itching unbelievable? Did most of your hair fall out? Did you finally respond to the double-dosing?
Avatar m tn both got weight-based RBV.Study numbers were small and the twice weekly IFN had no effect. Of note safety was NOT an isue with any of the doses noted above. All in all the second paper clinches it for me. It's clear that there is a trend toward higher dose and more frequent dosing schedule positively affecting RVR and SVR with Genotype 1, even with high viral load. The meta-analyses need to be done, but for me, twice weekly at 1.5 mcg/kg/dose seems right.
Avatar m tn Its a great day! Finished dosing yesterday after 24 weeks [12 VX & SOC + 12 SOC only]. Turned in my drug diary, extra meds, and presented my sharps container to my trial coordinator. Can't tell you how good it feels to be starting to wash out the tx meds and getting back to normal. You folks who do extended SOC and multiple rounds of tx have my complete respect.
Avatar n tn Curious on how much you weigh to see if your doc put your on the high end of a weight based riba formula or is just dosing high. Also, how has your hgb behaved with all the riba and are you on Procrit and if so how much.
427265 tn?1444080036 Here’s a link to another of Lindahl’s work proposing utilizing renal function as an alternative to weight-based riba dosing: http://www.ncbi.nlm.nih.gov/pubmed/14738562?dopt=AbstractPlus “Is it do-able?? I really want to do this, but I want to be able to stay in the game too.” Lindahl was able make this work; however the patients were most likely being monitored *very* closely; this was conducted as a clinical trial. My personal experience was OK; I tolerated >22.
Avatar f tn I weigh about 115 lbs (52 kg). According to weight-based guidelines, only 1000 mg (or even 800) of ribavirin would be recommended for someone my size. My question is this: If I reduce my dose to 1000 mg, would this be likely to stop this gradual hgb slide, without decreasing my chances of SVR? (I'm genotype 1. Viral load was 100 at 4 weeks and UND at 12 weeks.
26471 tn?1211940121 Peginterferon and Ribavirin Dosing and the Utility of Growth Factors Mitchell L. Shiffman, MD Effect of interferon dosing on virologic response It has long been recognized that the ability of interferon to reduce HCV RNA in serum is a dose-dependent process.