Ribavirin dosing

Common Questions and Answers about Ribavirin dosing

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Avatar f tn The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.pdf Ribasphere RibaPak (ribavirin, USP) doesn't give a designation as to reduce too 1 or 2 times a day dosing, copegus does.
223152 tn?1346981971 If I were treating, I personally would ask my doctor about pre-dosing ribavirin. At the same time........I wouldn't worry too much if pre-dosing is an option that's not available to someone. It's another theory that people discuss and perhaps as people continue to discuss it and ask their docs about it, it will be considered more but it's not common. The odds of SVR in all the trials are not based on pre-dosing added into the mix.
1747881 tn?1546179478 I am in a trial that will be comparing ribavirin dosing, weight based compared to concentration controlled based on AUC 0-12 after first dose. http://clinicaltrials.gov/ct2/show/NCT01097395?
Avatar m tn This isn't adding a drug that has never been used with the PI's before so you're not introducing a wildcard here, you're taking something that already has an established integral relationship with a PI throughout many many trials. Pre-dosing ribavirin is ribavirin mono-therapy for X number of weeks in the hope that when you take your first INF injection, the ribavirin is already at maximum synergistic capability.
Avatar f tn I an also Genotype 2. Have your doc look at weight based dosing and stats for SVR using this protocol. Once mine did I,was bumped up to 1200. He also recommended that I take an AD as he has had patients who at a higher dose experienced depression and riba rage.
Avatar n tn When I re-tx, and assuming it's with riba and IFN I have been playing with the idea of pre-dosing with riba for a few days to a week before the first IFN. I have leftover riba from tx#1 and am kicking the idea around. Although it's true that riba alone is not effective, it takes time to get to the saturation levels for riba. The reason I may do so is my intent to get to undetectable by week 6 and then add 36 weeks. I'm a replapsed geno 3. Will also be consulting a doc about the strategy.
476246 tn?1418874514 I know I'm posting terribly much today, but my brain is hyperactive and quite clear today, so I'm trying to use it while it lasts. Dosage Ribavirin 1000mg Considering that I have read that the sx of Riba can be agitating and might make it difficult for you to sleep, would it make sense to take it. Deb_c430 mentions on another thread, if I may quote, that if she takes her riba to late it does cause more agitation and sleeplessness.
135456 tn?1301441224 If you previously did 1800 mg/day of ribavirin a day for 72 weeks, maybe either the ribavirin isn't the problem at all, i.e. pre-dosing isn't the answer -- or, you're not absorbing the riba very well, a crude measure of which would have been your hemoglobin response during treatment. Anyway, taking the pre-dosing out of the equation, it seems that the only thing you're doing different this time is swapping 72 weeks of Infergen for 72 weeks of SOC.
135456 tn?1301441224 I haven't been able to find any ribavirin pre-dosing studies, although someone did post here about a year ago which suggested that one such study may exist. If so, it appears to be a carefully guarded secret :) That said, the concept of pre-dosing ribavirin makes sense to this non-medical professional on a logical basis. Since it takes 2-4 week for ribavirin to reach maxium serum levels, then in a sense, if we don't pre-dose ribavirin, we are under-dosed for the first 2-4 weeks of treatment..
Avatar f tn I plan on taking my first injection tomorrow eveining but in my brain fog state can't remember when I start the ribavirin pills. Is it the morning of the day I take the first shot or the morning after. I was on pegasus treatment for 48 weeks in 2011 and relapsed after a month TX was finished. I'm not out of my mind yet but my doctor doesn't work on Fridays and I have no one to ask this.
2202729 tn?1377554805 just wondering if anyone has double dosed on ribavirin i think i was having a interferon weekend .
Avatar n tn Patients weighing < 65 kg received 800 mg/day; patients 65 to < 85 kg received 1000 mg/day; patients 85 to < 105 kg received 1200 mg/day; and patients 105-125 kg received 1400 mg/day.
Avatar n tn i want to continue until my enzymes are better, but not for too long. i figured it would be worth double dosing starting now for 4 more months ,giving a total of 36. this would only give me 15 weeks of UND. i figured since im already 5 months in, this strategy would at least give me a small chance for an accidental SVR. i know the chances are slim but as for as i am concerned all is lost for this round, and SOC in general. for me anyway. what do yall think.
Avatar n tn At the time I was told I was between stage 3 and 4, although later turned out I was probably closer to stage 2-3. Both the double-dosing and higher doses of ribavirin were my idea although the double-dosing was one of my doctor's protocols for selected cases. So while not common, some doctors like mine do double-dose right off the bat in hard to treat cases, or by request :) I got the idea for the higher doses of ribavirin from the Sweedish study.
910090 tn?1332171060 Normally I take my Ribavirin at 6:30am (along with my VIC) and 6:30 pm. I fell asleep before my 10:30pm VIC dose and woke up to my alarm. I was in such a deep sleep I wasn't fully awake and when I took my VIC, I also took my daily meds of ribavirin as well as my ADs. So here I am at 6:30 am wondering if I should take today's morning dose of RIba with the VIC or wait til my 6:30pm schedule. That would be a 20 hour lapse between doses! Yikes!
Avatar f tn Normally, first dose of riba is taken the morning of the first day with second dose and injection to follow in the evening. Florida Guy and a few others have pre-dosed ribavirin a week or so before the first shot. Something to discuss with your doctor.
Avatar n tn Anyone who has had any experience or information about double dosing please give me your experience. Thanks for you help.
Avatar n tn what are some articles and studies on the above and on maintainance dosing? indi,maj,scott...or anyone have info handy that i could look at that might address these issues? also does anyone have the article/info on, HOW LONG AFTER FIRST CLEAR VIRAL LOAD TEST should we tx to insure best outcome for svr...??? (cont.
Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
Avatar n tn there's a big difference between adding Riba from 1200 to 2000mg a day like you did which is WAY off label for Riba dosing and not within any "normal" riba dosing parameters, no one I have ever heard of is advised to take that much Riba. I think you did that based on one Swedish study and it landed you in the hospital. He is only increasing his Riba one pill or 200mg. not 800 mg as in your case. There is a BIG difference between 200mg and 800mg.
Avatar f tn There is a ribavirin wt based dosing schedule in table 1 and 2, just follow the link http://www.gene.com/gene/products/information/pegasys/pdf/copegus_pi.
Avatar m tn High Ribavirin? I am thinking about trying tx in a clinical trial with high riba. (about two times normal). It seems like a lot of people here who did clear with SOC had more side effects than those who did not clear. I had few side effects but also did not clear. Maybe its the riba I thought jmjm530 cleared using lots of Riba? Anyone else do this or have thoughts?
Avatar f tn My physician's assistant called yesterday and said I am anemic and to take a shot of procrit. Also to reduce to 400mg/day ribavirin instead of my 800mg. I am in week 15 and have been UND at week three on triple therapy with incivek. Genotype 1a. Weigh 140 lbs. I was on 1000mg for 6 weeks and for the remainder of the time have been on 800mg. Yesterday I started on 400 mg and am worried about relapse. What is the role of ribavirin and just how important is it to SVR? I am on course for 24 wk.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
9648 tn?1290094807 Weight-adapted ribavirin dosing in combination with peg-IFN alfa-2a to avoid giving low doses of ribavirin should be evaluated. This will minimize relapse, especially in HCV GT 1 patients.
1476285 tn?1287341384 Hi I am curious if anyone has found a chart or info on how much interferon, ribavirin and telaprevir a person should take based on their weight. Maybe some of these are not even weight based altho it sure seems like a 100# person would not require as much of any of these as a 300# person but I don't know. If anyone has a link to this or a chart or any info, I'm just curious to know.
Avatar n tn is that there is little data collected on pre-dosing ribavirin in terms of SVR. Intuitively, one would think it would help, but again no hard data. Also, there's the chance of more drug toxcity/side effects which could come back and bite you. As to when you start counting for RVR, EVR, etc. I would start counting at the first peg shot. Again no data here but that's how I would do it.
Avatar f tn There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://www.gene.com/gene/products/information/pegasys/pdf/copegus_pi.
29837 tn?1414538248 The double dosing will consist of double Pegasys and the standard, torturous Ribavirin. I would like to know if anyone has undergone this double dosing regiment. If so, how was it? Did you eat and sleep normally? Were you prone to lashing out at your friends? Did you have a hard time breathing? Were you extremely depressed? Was the itching unbelievable? Did most of your hair fall out? Did you finally respond to the double-dosing?
427265 tn?1444080036 And again, I'd bring up the discussion of pre-dosing ribavirin and Alinia. Pre-dosing doesn't have much study backing but Dr. Dieterich in our Expert Forum likes the concept. There are studies to support Alinia as an additive. As to viral load testing, ironically most doctor's (good ones included as well as their NPs) often don't have a clue what an insurance company will cover and what it will not.