Ribavirin molecular weight

Common Questions and Answers about Ribavirin molecular weight


135456 tn?1301441224 7 µmol/L expresses concentration as molarity whereas both the French and Japanese studies used weight (g/ml) so you'd need riba's molecular weight, which should be on the drug's data sheet, to compare.
Avatar f tn known as trycyclics and tetracyclics...they are taken at night...make you sleep better...and have a different molecular weight and function....they still cause seretonin uptake changes and help.... personally, the riba made me so speedy the last thing I needed was a prozac class drug. plus, my stage of disease had me concerned about the danger to the liver the SSRI's are known for.....we opted for a tetracyclic called remeron....and sometimes I take a small dose of Ativan on bad days...
Avatar m tn 21 Peginterferon is synthesized by the chemical conjugation of a PEG molecule with an average molecular weight of approximately 40 kDa or 12 kDa to interferon- α2a (peginterferon-α2a) or to interferon-α2b (peginterferon- α2b), respectively. The size of the PEG moiety results in sustained delivery and reduced clearance providing the possibility of once weekly dosing.
173930 tn?1196341998 But I'm pretty sure the arthritic stiffness will go away in time, and I'm really to blame for the weight gain. I've been putting back a few too many microbrews and generally eating too much good food (and honestly not feeling guilty about it either!) since stopping treatment. No exercise to speak of either, so I can't really solely blame tx for that problem. Otherwise I feel fantastic and look healthy.
Avatar f tn Is Pegasys administered based on weight also? My husband's has the pink cap. Are there studies showing that weight based dosing is more effective? Does anybody have any links to the correct dosing charts, it doesn't appear on the drug insert.
1118724 tn?1357014191 The empirical formula of ribavirin is C8H12N4O5 and the molecular weight is 244.2. Ribavirin is a white to offwhite powder. It is freely soluble in water and slightly soluble in anhydrous alcohol. COPEGUS (ribavirin) is available as a light pink to pink colored, flat, oval-shaped, film-coated tablet for oral administration.
148588 tn?1465782409 [15,16] Our group conducted a randomized, open-label phase III study to directly compare weekly peginterferon alfa-2a with 2 different doses of biweekly albinterferon alfa-2b (900 and 1200 μg), all of which were administered with weight-based ribavirin for 48 weeks (Capsule Summary).[17] This pivotal study included 1323 treatment-naive patients with chronic genotype 1 HCV infection.
Avatar n tn Have you lost a lot of weight? Rebetol is weight based therapy. And I was allowed to reduce it from 5 pills to 4 a day recently. I lost 14 lbs. They don't want you to reduce it at all for the first 12 weeks. Also geno 1A. Week 34/51. You have to as the people in charge of the trial. You don't want to do anything to invalidate the trial results.
Avatar m tn k which suggests you have plenty of ribavirin in your system-not sure why he wants to increase,but basically the more ribavirin you can tolerate whilst clearing the virus the better. After you are 'negative' it is not so important. If your viral load is about 5000 at week 12 you would need to do a total of 72 weeks to have a decent chance of SVR,assuming you were negative at week 24. Good luck-you cant predict the 12 week test=you might get a nice surprise.
2030686 tn?1351692148 It is hardly surprising that some of the usual side effects of taking interferon are actually flu-like symptoms. Ribavirin Ribavirin is a synthetic antiviral nucleoside analogue. In the treatment of hepatitis C it works very successfully with interferon but not on its own. It was originally developed as an antiviral agent for diseases that cause respiratory problems. The possibility for it being used in conjunction with interferon was first noted in 1990.
Avatar n tn rearfang,i forgot whether or not you may have mentioned your weight but pegintron uses weight based formula so this is a benifit for overweight people. but it doesn't sound like you would have controll over this in the study anyway. also, pegasys probably won't pay for procrit so is this a concideration for you? i pray for wisdom for you for your decision.
Avatar f tn Among the regimens that have been approved by the FDA for patients with HCV genotype 1 infection who have not had a sustained virologic response to prior interferon-based therapy — historically, the population hardest to cure — are 12 weeks of sofosbuvir with peginterferon and ribavirin or 24 to 48 weeks of simeprevir with peginterferon and ribavirin.
Avatar m tn The documents for your trial don't say what the dosages for SOC are. I would ask what the ribavirin dosage is and ask if it's weight-based. I am in a trial myself right now but if the ribavirin dosage wasn't weight-based, I wouldn't have gone in it. I'm wondering if you've had a biopsy and what the results were? I'm also wondering what your viral load is...do you know this?
Avatar m tn The only US Food and Drug Administration-approved treatment for hepatitis C is combination therapy with pegylated interferon alfa and ribavirin (standard of care), which leads to a sustained virologic response (SVR) in approximately 80% of patients infected with hepatitis C virus (HCV) genotype 2, approximately 60% to 65% infected with genotype 3, and approximately 40% of patients infected with HCV genotype 1.
Avatar m tn Along these lines of thought, Maynard and colleagues[27] found that high plasma ribavirin concentrations strongly predicted SVR in 22 patients receiving weight-based peginterferon alfa-2b plus weight-based ribavirin in a nonrandomized study (Capsule Summary). Patients who had a Week 4 plasma ribavirin concentration > 1.89 mg/L had a 70% probability of achieving an SVR, with a sensitivity of 70% and a specificity of 75%, whereas those with a plasma ribavirin concentration > 2.
Avatar n tn 3 The design of low-molecular-weight NS3 serine proteinase inhibitors is particularly challenging, however, because the enzyme's active site is long, shallow, and exposed, offering little grasp for small inhibitor molecules.
1331115 tn?1536365740 The IUPAC name for telaprevir is (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(3S)-1- (cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-1-carboxamide. Its molecular formula is C36H53N7O6 and its molecular weight is 679.85. Telaprevir drug substance is a white to off-white powder with a solubility in water of 0.0047 mg/mL.
1021643 tn?1265577448 This usually doesn't happen with Peginterferon 2b as it has a lower molecular weight. Your body will get used to it and it will sort itself out eventually. As long as your doctor is aware of it happening and is not concerned you can relax about it. You'll be ok.
789911 tn?1368640383 They had found people in SOC and triple tx were drinking not enough or too much water depending on weight (50% body weight vs oz water). In drinking too much water, although hydrating, our electrolytes are being flushed out unknowingly. I am confirming this w my physician tomorrow. Thought y'all might be interested in that ditty.
233616 tn?1312790796 gov/pubmed/1695539?dopt=Abstract), (and assuming a drop in VL no doubt) Finally ribavirin metabolism involves several cytochromes. but primarily 2D6 and 3a. Here I would focus on the cyp 3a, because the telaprevir or boceprevir are also reliant on this cytochrome. Meaning this cytochrome will have plenty to do while you are treating. My SUGGESTIONS to the patients, and the high risk or late stage patients especially would be 1.
Avatar m tn End of Treatment Response for PEG-IFN + Weight-Based Ribavirin Nonresponders Retreated with Consensus Interferon Plus Ribavirin</a> <a href="http://www.hivandhepatitis.com/2004icr/ddw2004/docs/0516/051604_hcv_b.html">Interim Results of a Pilot Study of the Combination of Consensus Interferon and Interferon Gamma in HCV Nonresponders to Peginterferon Alfa 2 Plus Ribavirin</a> <a href="http://www.hivandhepatitis.com/2004icr/ddw2004/docs/0516/051604_hcv_a.
Avatar m tn Subanalysis by Race/Ethnicity, Weight and HCV Genotype. M. Rodriguez-Torres; J. Lalezari; E. J. Gane; E. DeJesus; D. R. Nelson; G. T. Everson; I. M. Jacobson; K. Reddy; J. G. McHutchison; A. Beard; S. Walker; W. Symonds; M. M. Berrey View Pres. 1869. Hematologic safety data from the IDEAL Trial: neutropenia, anemia and thrombocytopenia profiles of Peginterferon alfa/ribavirin. F. Poordad; N. Brau; E. J. Lawitz; M. L. Shiffman; J. G. McHutchison; A. J. Muir; G. Galler; J. McCone; L.
135456 tn?1301441224 In wondering if there was any connection between feeling the after effects of treatment when the meds were stopped and little research out there about Ribavirin that I had started doing a little research myself and had come to the conclusion that the miracle of ribavirin is still a mystery to everyone.
Avatar n tn After that you can move on to iridology, reflexology, light healing, phrenology, and doing Guess-Your-Weight at the county fair.
264233 tn?1216345915 16 Preliminary data from a recent study17 show that darbepoetin alfa therapy (3 mg/kg every other week) in patients with chronic hepatitis C increases hemoglobin levels and also allows for maintenance of the optimal weight-based dose of ribavirin in 83% of patients, suggesting that it may be beneficial as an adjunct to combination therapy for HCV infection. Improvements in health-related quality of life also were noted after initiation of darbepoetin alfa.
86664 tn?1291561395 While the resistance propensity of antivirals differs widely due to mechanism, suppressive power, molecular target and the ease with which HCV can produce mutants fit enough to suceed, the working hypothesis must be that no mono and likely no simple dual therapy can retain this virus from adapting. Note that IFN is not just a " monotherapy" but has multiple , complex activity against HCV, classifying it a priori as " pseudocombotherapy).Apparantly not comboish enough, however.
Avatar m tn We evaluated retrospectively 188 naïve CHC patients receiving peginterferon plus ribavirin at standard weight-based doses for 48 weeks (96M/92F; mean age 42.75 ± 0.84; mean weight 69.63±1.11 Kg; mean BMI 24.03±0.4). Genotype 1 HCV was confirmed in all cases by PCR analysis with type-specific primers for identification. Biopsies were assessed for inflammatory activity and fibrosis, as quantified by the modified Knodell histological activity index.
Avatar n tn interferon lambda 3) region has been associated with sustained virological response (SVR) rates in patients with chronic hepatitis C (CHC) who were treated with peginterferon-α and ribavirin. We hypothesized that IL28B polymorphism is associated with intrahepatic expression of interferon-stimulated genes (ISGs), known to influence treatment outcome. IL28B genotyping (rs12979860) and whole-genome RNA expression were performed using liver biopsies from 61 North American patients with CHC.
Avatar m tn 4 micrograms/liter. Knowing the molecular weight of RSV to be 228g/Mol this translates into 14.4/228 micromolar max achievable concentration ,so approx 0.06 micromolar. If you place this result in the almost linear dependence of replication enhancement foldness of the above paper (see fig 2 AND 4) you will see that the enhancement at this in vivo micromolarity is somewhere between 1 and 5% of starting value, a totally irrelevant phenomenon, if we take everything at face value.
Avatar n tn was the goal of therapy and future therapies (and that that was the reason VX-950 needs help with Peg/Rib). Wasn't it the addition of Ribavirin that helped reduced the incidence of viral breakthrough and that without Ribavirin there is "breakthrough"?