Ribavirin patients

Common Questions and Answers about Ribavirin patients


188500 tn?1207368551 I guess it depends on just how much Ribavirin your daily dosage is.....Mine is 1200 mg's..I was in great shape when I started tx,But i can say this during the loading phase my irritablity level went thru the roof..A fly would fart in Africa and I'd get PO'd.....The feeling was kinda like that of a car with the enigine reved to full throttle in gear but WITH THE BRAKES ON....constant tension..And Yes it affected my sleep greatly.....
476246 tn?1418874514 I know I'm posting terribly much today, but my brain is hyperactive and quite clear today, so I'm trying to use it while it lasts. Dosage Ribavirin 1000mg Considering that I have read that the sx of Riba can be agitating and might make it difficult for you to sleep, would it make sense to take it. Deb_c430 mentions on another thread, if I may quote, that if she takes her riba to late it does cause more agitation and sleeplessness.
Avatar f tn If you are on triple therapy for genotype 1 and undetectable then your doc is following AASLD protocol for anemia management Anemia developed among recipients of both PIs. Hemoglobin decreases below 10 g/dL (grade 2 toxicity) occurred in 49% of patients who received a BOC regimen compared to 29% of those who received the SOC regimen, whereas 9% had a hemoglobin decline of <8.5 g/dL (grade 3 toxicity).
Avatar m tn Fifty patients with chronic hepatitis C virus (HCV) infection genotype 1 were randomly assigned to groups that were given peginterferon alpha-2a, with or without ribavirin, for 4 weeks; all patients then received an additional 44 weeks of combination therapy. First- and second-phase viral kinetics were evaluated.
Avatar m tn High Ribavirin? I am thinking about trying tx in a clinical trial with high riba. (about two times normal). It seems like a lot of people here who did clear with SOC had more side effects than those who did not clear. I had few side effects but also did not clear. Maybe its the riba I thought jmjm530 cleared using lots of Riba? Anyone else do this or have thoughts?
Avatar f tn 79% with telaprevir triple therapy and 46% with pegylated interferon/ribavirin among patients who never reduced their ribavirin dose; 75% and 54%, respectively, among those who used 800-1000 mg/day ribavirin; 74% and 42%, respectively, among those who used < 600 mg ribavirin.
Avatar f tn it is now recognized that small reductions in the dose of peginterferon alfa and/or ribavirin, particularly after patients achieve undetectable HCV RNA, are less likely to impact SVR as long as dosing is not interrupted.[15,23]" 15. Reddy KR, Shiffman ML, Morgan TR, et al. Impact of ribavirin dose reductions in hepatitis C virus genotype 1 patients completing peginterferon alfa 2a/ribavirin treatment. Clin Gastroenterol Hepatol. 2007;5:124 129. 23. Shiffman ML, Ghany MG, Morgan TR, et al.
Avatar m tn The only difference is my treatment is that for the last 2 weeks I switched to a differenr Ribavirin brand. First 40 weeks I took Ribasphere (Ribavirin Capsules) made by DSM Pharmaceuticals, Greenville, NC The label indicates that each capsule contains Ribavirin, USP - 200mg For the last two weeks I started to take Ribavirin Tablets, made by Sandoz, Princeton, NJ Each film -coated tablet contains :Ribavirin 200 mg My question: Could it possibly be any difference between the two?
10318302 tn?1409260268 Alternate regimen for HCV genotype 4, PEG/RBV nonresponder patients. Daily sofosbuvir (400 mg) and weight-based RBV (1000 mg [<75 kg] to 1200 mg [≥75 kg]) for 24 weeks is recommended for retreatment of HCV genotype 4 infection. Sounds like this is the preferred treatment for your GT 4. I think you will find it easier than your prior treatment since you won't be taking the interferon shots.
Avatar f tn Am I the only one on here taking 1,200 mgs of ribavirin, who is going thru Triple Tx? I keep noticing people mentioning lower dosages. I have heard of smaller people taking less, and I am 5'9'', 160 pounds, but I think my Doctor is prescribing this same amount for most of the people in my home group, that I've talked to.
310500 tn?1227304634 Only one response on this..... Is this not a concern for others. I hate to see the stuff go to waste as expensive as it is. Can anyone give me an idea. I was given a place in NY, but the link does not seem to work.
Avatar f tn Don't have all the numbers but viral load was 23,000,000 and biopsy showed inflammation and bridging fibrosis, (stage 3?). I'm on week 7 out of first 12, pegasys/1000 ribavirin. Doc won't do comprehensive tests to see if working until week 12, then if responding will do 48 weeks. Blood work showed slight anemia this week, he wants me to cut ribavirin to 600. He did say after checking numbers next week we may look into rescue drugs for the anemia.
Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
1769355 tn?1319207762 hallo,I've visited a web site for coinfected patient (HCV+HIV)and I discover that often ribavirin therapy associated with some inibithor of the protease could cause injury.For example I use norvir,and 2 more different drugs ,for cure my HIV and I've read that Ribavirin +Norvir can cause direct liver injury.I discover for genotype 2and 3 the therapy duration are raccomended for 24 week and for genotype1and 4 are for60-72 week as slow responding.
158241 tn?1237723123 com/35zu3n Fulltext pdf download Pharmacokinetics of ribavirin in patients with hepatitis C virus Janet R.
26471 tn?1211940121 The greater induction of interferon-stimulated cytokines and the correlation with viral kinetics in ribavirin-treated patients, support the notion that the effect of ribavirin may indeed be mediated through augmentation of interferon signaling. Do you think its possible that Riba can reduce IR and thereby improve Interferon signalling if the serum concentration is high enough. The Lindahl high dose Riba study indicates Riba does something if the concentration is high enough.
Avatar f tn Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Ribavirin has demonstrated significant teratogenic and embryocidal effects in all animal species in which adequate studies have been conducted. These effects occurred at doses as low as one twentieth of the recommended human dose of ribavirin.
Avatar m tn That trial was up to 48 weeks of Sovaldi + ribavirin treatment. Its purpose was to learn if transplant patients could safely treat there hep C with class A cirrhosis until the day of their transplant and not have recurring hep C post transplant. 64% of the people in our trial didn't experience recurring hep C after transplant. I ended treating for all 48 weeks but was unable to get a transplant in time before the virus can back one month after being undetectable for over 47 weeks.
Avatar f tn ok - upon reading the actual study, it seems to me that what they are saying is that when people are effected with anemia to the point that their ribavirin has to be reduced in order to complete the treatment, this is a good indication that the ribavirin is working as it is supposed to and those patients who had that level of anemia attained SVR more often DESPITE the reduction by up to 50% of the riba. http://content.nejm.
Avatar f tn 24 to 48 weeks -Retreatment with interferon alfa-2b/ribavirin in patients who relapse after nonpegylated interferon monotherapy: 24 weeks Comments: -The manufacturer's product information for peginterferon alfa-2b or interferon alfa-2b should be consulted. -Combination therapy with peginterferon alfa-2b is preferred; provides substantially better response rates than combination therapy with interferon alfa-2b.
Avatar n tn I began treatment about a month ago. My first prescription for ribavirin was filled with non-generic Rebetol at a cost of $1,100 for quantity of 120. This month I filled my second prescription for ribavirin. This prescription was filled with generic Rebetol at a cost of $90 for the same quantity. This was a very pleasant surprise. Can anyone comment on the efficacy of the generic vs the non-generic ribavirin?
Avatar m tn Does anyone know of any programs that offer assistance with the coverage gap (donut hole) for people on Medicare? I have been preapproved for Pegasys and Ribavirin but my Medicare Prescription Drug Plan through United Health Care has a $4,550.00 coverage gap and then 5% of the total drug cost approx $9200.00 a year. The plan starts anew Jan 1st of each year so I’m looking at a copayment in the excess of $18,400.00.
476246 tn?1418874514 I planning to take my morning ribavirin with my breakfast with a chunk of cheese. I am also taking krill oil, which one is supposed to take with the first meal. My question is if it is okay to take either krill oil or fish oil at the same time as the riba?
3093770 tn?1389742726 00 am then again when I ate diner, I was in a ribavirin study and the study docs were ok with that schedule Pharmacokinetics Multiple dose Ribavirin pharmacokinetic data are available for HCV patients who received Ribavirin in combination with peginterferon alfa-2a. Following administration of 1200 mg/day with food for 12 weeks mean ± SD (n = 39; body weight > 75 kg) AUC0-12hr was 25,361 ± 7110 ng•hr/mL and Cmax was 2748 ± 818 ng/mL. The average time to reach Cmax was 2 hours.
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
Avatar f tn yes people are curing with this combo however Ribavirin is not always needed with viekira pak it depends on genotype of hep c and if you have cirrhosis
427265 tn?1444080036 dopt=AbstractPlus It’s important to note that the Lindahl study used methods other than weight basing to determine max dosing schedules; that two patients required transfusions, and all patients required epo. Here’s a link to another of Lindahl’s work proposing utilizing renal function as an alternative to weight-based riba dosing: http://www.ncbi.nlm.nih.gov/pubmed/14738562?dopt=AbstractPlus “Is it do-able?? I really want to do this, but I want to be able to stay in the game too.
1225178 tn?1318984204 Therefore, people infected with HCV are not hazardous unless they somehow expose others to their blood. It is recommended that patients with PCT be tested for HCV infection. This is done by a blood test that detects antibodies to the virus. If HCV infection is found, it may not change the treatment of PCT (by phlebotomy or low-dose chloroquine). Treatment for PCT is highly successful even in patients with HCV.