Ribavirin drug information

Common Questions and Answers about Ribavirin drug information


Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
Avatar f tn Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material. Though not effective against all viruses, ribavirin has important activities against influenzas, flaviviruses and agents of many viral hemorrhagic fevers. Ribavirin is a pro-drug, meaning that it is a chemical precursor for the actual phamacologically active molecule.
Avatar m tn Ribavirin in the Treatment of Chronic Hepatitis C Paul Martin; Donald M. Jensen Posted: 09/04/2008; "...Results: Ribavirin may be effective in treating CHC by affecting the virus or the host; for example by inducing viral mutations, blocking cellular enzymes, or affecting the host immune response. Although the pegylated interferons are the primary drugs used to treat CHC, a combination with ribavirin is more effective than pegylated interferon alone.
Avatar f tn It's hard to give specific advice since we don't know your hemoglobin numbers (before and during treatment) nor your general health history -- nor none of us are doctors -- but in many cases doctors will start the rescue drug Procrit (epo) first, before lowering the ribavirin -- epc in cases of "slight anemia" which is pretty common on treatment. The fact that your doctor cut your riba in half and still hasn't prescribed Procrit is troubling to me.
310500 tn?1227304634 //www.cnn.com/video/#/video/living/2007/08/24/cnn.heroes.jesus.aquais.cnn I was reminded that if you need to refridgerate the meds to send overnight with cooler and ice packs. They will take open bottles of pills.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
Avatar m tn I have been preapproved for Pegasys and Ribavirin but my Medicare Prescription Drug Plan through United Health Care has a $4,550.00 coverage gap and then 5% of the total drug cost approx $9200.00 a year. The plan starts anew Jan 1st of each year so I’m looking at a copayment in the excess of $18,400.00.
Avatar f tn With regards to ribavrin and sperm, in some respects, the jury is still out. Ribavirin can cause changes in the actual structure of the sperm. The drug is also found in semen. It is unsure whether or not the drug is present within the sperm cell or not. There is a registry of paternal ribavirin pregnancies carried to term and there have been results of successful presnancies.
3242225 tn?1348340121 Oh, I wish you luck so much. I just finished the 7977 and Ribavirin July 9. It is double blind so no one will know if they are und until January. One thing that scares me though, my ALT was very low from week 2 on which is good and when I finished the drug it was 15 but then went up to 22 4 weeks after the end of the meds. I am worried because you'd think it would have stayed put. I know it's just 7 points but why would it go up at all?
Avatar m tn When I was a new member many years ago I listened to the sage advice of the forum guru (who actually had a study to point me to unlike this) ended up losing six full points on my hemo in just over one week and almost failed treatment by playing with ribavirin. It IS A MAJOR DRUG AND SHOULD NOT BE EXPERIMENTED WITH WITH THESE NEW PIs that already have severe side effects associated with them.
Avatar m tn Many of us have treated with the Sol/Riba (or sofosbuvir and Ribavirin - which has several generic names), you will get lots of information. This is a wonderful, knowledgeable, caring Forum. Again, welcome to the Forum.
Avatar n tn Good Morning, this is my first day of taking Ribavirin after learning of my diagnosis of Hep c on Saturday. Unfortunately, I am unable to sleep. I have taken 1 10mg. of Ambian to no avail. Is this a normal reaction? Also, I cannot get the vaccines until later this week. Will I be in any shape to go to work once I begin the full regiment of ribavirin and vaccines? Thank you in advance for any information.
26471 tn?1211940121 I think for the most part, doctors suffer from a lack of information on the efficacy of high-dose ribavirin, as well as a powerful motivation to keep from getting sued. Add this to what you suggested - a hopeful view toward small molecule therapy, makes high-dose ribavirin a risk most doctors wouldn't want to take.
223152 tn?1346981971 Based on the fact that interferon monotherapy is not effective, it's effective with ribavirin, and at full strength, I would rather have my ribavirin working at full strength when I start my interferon than have it take awhile after my interferon to get to full strength. There IS data on the amount of time it takes for ribavirin to get to full concentration AND there is data on the efficacy of ribavirin together with interferon.
Avatar n tn I have the kind of HCV positive(chronic) that does not respond so wellto interferon treatments. I have choosen to try this Interferon-Ribavirin therapy regardless with hopes of getting better. I start this therapy soon after the new year.I live in Bend,Oregon and feel I need to attend a support group either for Interferon-Ribavirin therapy users or HCV positive(chronic) patients. Do you know if there are support groups in my area????
1838299 tn?1403496143 Is anyone on or finshed tx with Sovaldi + ribavirin + interferon for 12 weeks? I am curious about how many people are still treating with interferon cause i will be starting it in October. Plus, how were the side effects and did any SRV? I am tx naive. .
408795 tn?1324939275 More... ///////////////////////////////////////////////////////////////////// Date: Dec, Fri 23 2011 12:19 -0500 (EST) Subject: FDA Hepatitis Update - Important updates to PegIntron labeling On December 22, 2011, the Food and Drug Administration approved revisions to the product labeling for PegIntron to include the use of PegIntron with hepatitis C virus (HCV) NS3/4A protease inhibitors for the treatment of genotype 1, chronic hepatitis C (CHC) infection.
Avatar m tn has anyone heard of the drug, Bucephavir, my doc said I should wait for it. Hep C 1A did 48 months, cleared at 12 weeks, but it back.
Avatar f tn Currently, the Standard of Care that has been adopted for HCV management consists of the drug ‘pegylated interferon’, along with the drug ribavirin. The chances of eradicating the virus are dependent upon genotype. Typically, genotype 1 patients have a 45% chance of viral eradication; this requires treatment duration of 48 weeks minimum. For genotype 2 and 3 patients, the odds of clearing the virus increase to about 75-90%, with a treatment duration of 24 weeks, generally.
29837 tn?1414538248 NM283 is a newer drug that combined with Peg Intron and Ribavirin is supposed to act on non-responders like myself. Naturally, I'm a little hesitant to enroll in this trial without further information, since I've failed three brutal treatments already. Has anyone gone through or anyone know someone who's gone through this NM238 clinical trial? If so, has there been any success or just more torture? Any info will be greatly appreciated.
Avatar m tn I also recently learned I have relapsed after completing the 12 week treatment with Solvadi and Ribavirin. I have Hep-C, genotype 2. The virus went undetectable after 4 weeks and remained that way 6 weeks after completing treatment, then showed up in a blood test done at the 12 week marker after treatment. Needless to say I was heartbroken. I was diagnosed in 1993 and have significant cirrhosis. I will keep hoping for a new drug protocol that will knock it out once and for all.
Avatar m tn I also heard it will have a possible 80% cure rate. Can you give me any information on this drug so I can pass it on and talk to my Doctor here in Atlanta about it?
233616 tn?1312790796 Because plasma concentrations of ribavirin are important for both efficacy and toxicity, factors that influence the pharmacokinetic profile of ribavirin are thus of great clinical significance as they affect the drug disposition and, consequently, therapeutic outcome and disease progression of the patient. As a consequence of its poor oral absorption profile (bioavailability 50%), ribavirin absorption is particularly prone to interference by food.
1893294 tn?1321220750 com/hepatitis-c/hepatitis-c-topics/hcv-treatment/4082-easl-2013-abbvie-interferon-free-combination-cures-over-90-of-hepatitis-c-genotype-1 Summary of Key Conclusions Treatment with 4-drug regimen of ABT-450/ritonavir, ABT-267, ABT-333, and ribavirin (RBV) for 12 or 24 weeks achieved very high sustained virologic response rates at 24 weeks posttreatment (SVR24) in noncirrhotic patients infected with genotype 1 HCV SVR24 rates 90% to 96% in treatment-naive patients, 93% to 95% in
Avatar n tn It includes the Interferon and Ribavirin plus the boceprevir. This program is sponsored by the drug company. I'm not sure why more of you aren't doing the clinical trials. I have Insurance, so if I had to pay anything it would only be a co pay of $15 per prescription. In this case maybe $30 per month. I just did my screening today for this program and should be starting my TX in the next 30 days. I would hate to think of paying some of the prices you people are talking about.
Avatar f tn They told me that I could do the Pegasys/Ribavirin and be cured by July or to wait until August for when the new treatment is approved by my health insurance and be cured by October (by the way, I have genotype 2a). Me, being the type of person whom likes to take care of things immediately decided on the older treatment. I'm currently waiting on the call so they can FedEx me the medications.
135456 tn?1301441224 Have you had previous experience with 1600 mg/day of ribavirin? If not, you might start sooner and titer up more gradually to make sure that you can handle the dose. Keep in mind that it can take 1-3 weeks for a change in ribavirin dose to be reflected in your hemoglobin. Also, and again based on your previous treatment experience, consider Procrit (epo) coincidental with the riba pre-dosing for same reasons.