Ribavirin information

Common Questions and Answers about Ribavirin information


Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
Avatar m tn Solvaldi & Ribavirin could work together. Has anyone heard anything about this ? Also you can go to Web MD & qualify for a $ 5.00 Co-pay for a six month supply. This regiment, S& R is a 12 week program ! Gilead is giving to those that can't afford $ 1000.00 a pill . 12 week treatment for solvadi alone would be Eighty four thousand dollars !
Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar f tn Don't have all the numbers but viral load was 23,000,000 and biopsy showed inflammation and bridging fibrosis, (stage 3?). I'm on week 7 out of first 12, pegasys/1000 ribavirin. Doc won't do comprehensive tests to see if working until week 12, then if responding will do 48 weeks. Blood work showed slight anemia this week, he wants me to cut ribavirin to 600. He did say after checking numbers next week we may look into rescue drugs for the anemia.
Avatar m tn Ribavirin in the Treatment of Chronic Hepatitis C Paul Martin; Donald M. Jensen Posted: 09/04/2008; "...Results: Ribavirin may be effective in treating CHC by affecting the virus or the host; for example by inducing viral mutations, blocking cellular enzymes, or affecting the host immune response. Although the pegylated interferons are the primary drugs used to treat CHC, a combination with ribavirin is more effective than pegylated interferon alone.
310500 tn?1227304634 //www.cnn.com/video/#/video/living/2007/08/24/cnn.heroes.jesus.aquais.cnn I was reminded that if you need to refridgerate the meds to send overnight with cooler and ice packs. They will take open bottles of pills.
Avatar f tn Am I the only one on here taking 1,200 mgs of ribavirin, who is going thru Triple Tx? I keep noticing people mentioning lower dosages. I have heard of smaller people taking less, and I am 5'9'', 160 pounds, but I think my Doctor is prescribing this same amount for most of the people in my home group, that I've talked to.
Avatar f tn My physician's assistant called yesterday and said I am anemic and to take a shot of procrit. Also to reduce to 400mg/day ribavirin instead of my 800mg. I am in week 15 and have been UND at week three on triple therapy with incivek. Genotype 1a. Weigh 140 lbs. I was on 1000mg for 6 weeks and for the remainder of the time have been on 800mg. Yesterday I started on 400 mg and am worried about relapse. What is the role of ribavirin and just how important is it to SVR? I am on course for 24 wk.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
Avatar m tn However, my kidney function is insufficient - better than 50%, but not by much. Ribavirin will be necessary with sofosbuvir alone, and it might be necessary even with sofosbuvir/gs-5885, or a similar combo. Does anyone know how harsh ribavirin is on the kidneys? I have tried to do research, but most of what I come up with involves ribavirin AND interferon. Any insight would be greatly appreciated.
Avatar f tn Here is the information from the package insert for Ribavirin: Warnings and Precautions Pregnancy Ribavirin Capsules may cause birth defects and death of the unborn child. Ribavirin therapy should not be started until a report of a negative pregnancy test has been obtained immediately prior to planned initiation of therapy. Patients should use at least two forms of contraception and have monthly pregnancy tests during treatment and during the 6-month period after treatment has been stopped.
2030686 tn?1351692148 FULL PRESCRIBING INFORMATION: CONTENTS* WARNING: RISK OF SERIOUS DISORDERS AND RIBAVIRIN ASSOCIATED EFFECTS 2 DOSAGE AND ADMINISTRATION COPEGUS should be taken with food. COPEGUS should be given in combination with PEGASYS; it is important to note that COPEGUS should never be given as monotherapy. See PEGASYS Package Insert for all instructions regarding PEGASYS dosing and administration. 2.
Avatar m tn Does anyone know of any programs that offer assistance with the coverage gap (donut hole) for people on Medicare? I have been preapproved for Pegasys and Ribavirin but my Medicare Prescription Drug Plan through United Health Care has a $4,550.00 coverage gap and then 5% of the total drug cost approx $9200.00 a year. The plan starts anew Jan 1st of each year so I’m looking at a copayment in the excess of $18,400.00.
Avatar m tn http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804105/ The above study also indicates that lean body weight has an impact on levels in the blood. I'm in my first week of triple tx with Incivek so my morning dose of RBV is taken with the fatty meal for that. It's the evening dose that I am not taking with a fatty snack because of the difference in the 8 hour /12 hour dosing schedule.
Avatar m tn .The package insert simply says take with food , no designation as to how much or what, follow the link to see more on the subject. http://www.medhelp.org/posts/Hepatitis-C/Starting-Week-12-on-INC---THEN-WHAT-/show/1637168 .
Avatar m tn I began a 12 week treatment of Sovaldi /Ribavirin treatment for HCV 20 days ago. On the 17th day I developed a rash on my lower left leg. by the 18th day, my body was covered over 85% with the itchy red rash. I called the Sovaldi helpline and a nurse called me back. She said that they have not had any case reporting a rash on Sovaldi. I went to see my prescribing APRN and she saw the rash and had me stop the Ribavirin but continue Sovaldi.
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
Avatar n tn I have finished with Incivek, thank God. I've had my ribavirin reduced to 200 mg a day and will do my 18th peg shot on Friday. The ribavirin was reduced due to my rash. Unfortunately the rash is everywhere again. I have atarax, doxepin and clobitisol. These give minimal relief. Now my hair is just falling out like crazy. To be honest i think i could deal with all of this except the hair thing.
Avatar f tn yes people are curing with this combo however Ribavirin is not always needed with viekira pak it depends on genotype of hep c and if you have cirrhosis
26471 tn?1211940121 I think for the most part, doctors suffer from a lack of information on the efficacy of high-dose ribavirin, as well as a powerful motivation to keep from getting sued. Add this to what you suggested - a hopeful view toward small molecule therapy, makes high-dose ribavirin a risk most doctors wouldn't want to take.
427265 tn?1444080036 Then I've got a support group of family and friends together to check on me daily at least until week 4 since I live alone. JUST in case....... You guys are a wealth of information and have a collective calming effect on me when I get into information overload. Yo're the BEST!!! Thanks you so much!
Avatar f tn Last week blood test hemoglobin is at 8.7. My doctor just reduced Ribavirin from 1000mg daily to 800mg daily for the reason that my hemoglobin is going down. Blood work again in two weeks and he will see me after the blood test results. He told me he might stop the treatment is the hemoglobin continues to low. He will make that decision in the next visit after seen the results of the blood test he ordered.
3242225 tn?1348340121 Has anyone gone through the HCV clinical trial with 7977 and Ribavirin for 12 weeks? RU undetectable?
Avatar n tn Good Morning, this is my first day of taking Ribavirin after learning of my diagnosis of Hep c on Saturday. Unfortunately, I am unable to sleep. I have taken 1 10mg. of Ambian to no avail. Is this a normal reaction? Also, I cannot get the vaccines until later this week. Will I be in any shape to go to work once I begin the full regiment of ribavirin and vaccines? Thank you in advance for any information.
Avatar m tn My doctor reduced my ribavirin dosage on 2/17/10 from 1200 to 600 and prescribed atarax (for the itching) because I was having severe rashes (still am) and he said if it got worse it could jeopardize my treatment . I have acute hepatitis c genotype 2 vl-52,000 I just took my 6th shot Friday. I was negative at 2 weeks and I am set for 24 weeks of treatment.
Avatar m tn Many of us have treated with the Sol/Riba (or sofosbuvir and Ribavirin - which has several generic names), you will get lots of information. This is a wonderful, knowledgeable, caring Forum. Again, welcome to the Forum.
1838299 tn?1403496143 Is anyone on or finshed tx with Sovaldi + ribavirin + interferon for 12 weeks? I am curious about how many people are still treating with interferon cause i will be starting it in October. Plus, how were the side effects and did any SRV? I am tx naive. .
Avatar m tn My concern with the antacids is that they might intefere with ribavirin absorption. Very little in the literature conclusive one way or the other. Wondering if any of you also take antacids and if you take them right after meals with your riba, or if you try to time the antacids a few hours before or after the riba.
223152 tn?1346981971 Based on the fact that interferon monotherapy is not effective, it's effective with ribavirin, and at full strength, I would rather have my ribavirin working at full strength when I start my interferon than have it take awhile after my interferon to get to full strength. There IS data on the amount of time it takes for ribavirin to get to full concentration AND there is data on the efficacy of ribavirin together with interferon.