Ribavirin drug interactions

Common Questions and Answers about Ribavirin drug interactions

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Avatar n tn What drug(s) are you concerned with ? There haven't been studies for drug interactions specifically with inteferon and ribavirin that I am aware of. I believe they can chemically rule out many without a study. With hundreds of thousands of ppl having done tx while taking other medications they have a pretty good idea by now what doesn't interact negatively with hcv tx drugs. I'd stay away from herbs (and other alternative 'meds') on tx. No sense in taking any chances.
Avatar m tn Hi, I think you've gotten good feedback. I, myself, did run into some drug/ drug interactions. I had to research like crazy , not from Gilead, to find some plausible answers. IMHO, these (I'm on Harvoni wk 10) are powerful enough meds to eradicate tenacious hepatitis & there is ALWAYS synergistic effects when meds are combined. Eg.
233616 tn?1312790796 Drug interactions in the Liver 101. What you need to know. My clinic has postponed treating any patients with triple therapy until their software is updated to include all of the newest information regarding P450 interactions. Therefore I’m NOT the only person realizing just how crucial and important this all has become. Ergo I’ve decided to regroup my thoughts and explain the basics.
Avatar n tn however, it was discussed in depth in the post below - Ribaviron/antacids/drug interactions Jmjm530 7/8/05. Scroll down and see if this gives you some answers. Someone will be along shortly with some more thoughts.
233616 tn?1312790796 Because plasma concentrations of ribavirin are important for both efficacy and toxicity, factors that influence the pharmacokinetic profile of ribavirin are thus of great clinical significance as they affect the drug disposition and, consequently, therapeutic outcome and disease progression of the patient. As a consequence of its poor oral absorption profile (bioavailability 50%), ribavirin absorption is particularly prone to interference by food.
2029713 tn?1373044704 Copegus (ribavirin) Paxil (paroxetine) Pegasys (peginterferon alfa-2a) Prilosec (omeprazole) Interactions between your selected drugs No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist.
Avatar f tn Drug Interactions Results Copegus (ribavirin) Incivek (telaprevir) Pegasys (peginterferon alfa-2a) Theraflu Flu & Cough (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine) Interactions between your selected drugs No results found - however, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist. http://www.drugs.com/interactions-check.php?
Avatar m tn RBV has the potential for dangerous drug interactions with didanosine resulting in mitochondrial toxicity with hepatomegaly and steatosis, pancreatitis, and lactic acidosis; thus, the concomitant administration of these 2 drugs is contraindicated. (Fleischer, 2004) The combined use of RBV and zidovudine has been reported to increase the rates of anemia and the need for RBV dose reduction; thus, zidovudine is not recommended for use with RBV AASLD/IDSA/IAS–USA. HCV testing and linkage to care.
Avatar n tn The problem with your loose talk is that you without doubt would not be able to produce any researh as to the affects of this drug in relation to hcv its histology,or interactions with pegalayted interferon, Ribaviron or the processes of fibrosis because there simply have not been the studies. Primarily because those prepared to px such expensive treatment usually live in hope that the patient will have the common sense to avoid possibly damaging drugs and just stick to the regime.
446474 tn?1446351282 com/HIVAIDS/HIVAIDS/31103 WASHINGTON -- A new drug for hepatitis C can reduce the effectiveness of some HIV medications if they are taken together and vice versa, the FDA is warning. In a drug safety communication, the agency warned that there are important drug interactions between boceprevir (Victrelis) and anti-HIV protease inhibitors boosted with ritonavir (Norvir). Boceprevir, approved last year, is a novel direct-acting agent targeting the NS3/4A protease of hepatitis C.
Avatar m tn Actually I don't think the released data was as good as what was expected.. (note: 61.5% cleared with soc..) "Idenix said it met the primary goal of showing no interactions between its drug and ribavirin among patients with a certain type of hepatitis C. Among 39 patients receiving a triple-drug combination, 72.2% achieved a significant reduction in the virus compared with 61.5% among 39 patients receiving the dual-drug standard of care.
131114 tn?1380086790 http://clinicaltrials.gov/ct2/show/NCT01353248 this is the new trials in tejas, anybody know about any of this stuff? i am having a tough time finding drug info. i'd really like to try the new pharmasset trials but for treatment naive only at this point. hope everyone's doing ok!!! happy halloween...
Avatar m tn Who’s Special? Resistance Drug-Drug Interactions DAAs by Class Nucleosides and Nucleotide Polymerase Inhibitors NS5a Inhibitors HCV Protease Inhibitors Simplified Drug Table (For more detailed listing of current trials for each drug, see Table 6.) TABLE 1. Direct-Acting Antivirals in Phase II and Phase III http://i-base.info/htb/16961#table6 The Next Generation Simeprevir (TMC435) BI 201335 Asunaprevir (BMS-650032) GS-7977 Daclatasvir (BMS-790052) Danoprevir/r Meek as a Lambda?
1887205 tn?1320927071 //www.drugs.com/drug-interactions/telaprevir,incivek.html There were no interactions found in our database between Pepto-Bismol and Pegasys http://www.drugs.com/drug-interactions/peginterferon-alfa-2a,pegasys.html There were no interactions found in our database between Pepto-Bismol and Copegus http://www.drugs.com/drug-interactions/ribavirin,copegus.
1947163 tn?1324296642 I would like to get any information from anyone that has had a liver transplant that is now taking the 3 drug treatment with Ribavirin, Incevic and Peginterferon, to combat the Hep C. Thank you!
Avatar m tn The management of drug-drug interactions during TVR exposure is a therapeutic challenge, but they may be more controllable if CSA is used as the main immunosuppressive agent. Triple therapy has an acceptable safety profile, although the treatment is quite intense with respect to cost and time. Therefore, we recommend that this therapy be conducted only by expert transplant hepatologists with strict surveillance of the patients because of the potential development of severe side effects.......
Avatar f tn Interferon alfa-2b/ribavirin Sudafed 12 Hour Pressure+Pain (naproxen/pseudoephedrine) Sudafed PE Cold & Cough (acetaminophen/dextromethorphan/guaifenesin/phenylephrine) http://www.drugs.com/interactions-check.php?drug_list=1356-0,1691-14288,56-13172 Add / Remove drugs Interactions between your selected drugs No results found - exist. ALWAYS consult with your doctor or pharmacist.
Avatar m tn No it is not to be taken under any circumstances-severe and deadly drug interactions. There are other AD's available.
1654177 tn?1319842094 I am waiting to hear back from my hep C doc to check on drug interactions. Anyway, I feel like the OTC sleep aid will be hard on my liver and renal system if I take them every night for the next 5 months. Does anyone else take a sleep aid? What are your thoughts or experiences? Does Trazodone have wierd side effects too? Thanks guys and gals!
Avatar m tn Your hep provider is in agreement with Medhelp’s ex resident HCV expert that grapefruit doesn't have interactions with Interferon & Ribavirin, Douglas Dieterich, MD Jun 13, 2008 It actually can increase some drug levels because of inhibiting a liver metabolic enyzme. However neither interferon or ribavirin is metabolized by that particular enzyme(p450) so it is OK to drink your grapefruit juice. http://www.medhelp.
2046312 tn?1360383200 Drug Interactions Results Copegus (ribavirin) Incivek (telaprevir) Klonopin (clonazepam) Pegasys (peginterferon alfa-2a) Interactions between your selected drugs clonazepam ↔ telaprevir Applies to: Klonopin (clonazepam), Incivek (telaprevir) MONITOR: Coadministration with telaprevir may increase the plasma concentrations of drugs that are metabolized by CYP450 3A4. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by telaprevir.
3145189 tn?1343161021 Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to Ribavirin. In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
163305 tn?1333672171 There are many dangerous drug to drug interactions between Incivek and post transplant drugs. Improper treatment could cause liver rejection or worse. She should only be doing treatment that is approved by her transplant center. It the TP center is doing a study then they will arrange for payment. It is not up to a RN to decide what treatment she should have.
2203249 tn?1338994046 If your boyfriend is on triple therapy make sure he checks with his treating doctor to make sure there are no drug to drug interactions between the antibiotic and the DAA drug he is taking. Good luck to him.
Avatar m tn FYI Drug interactions between clonidine and Sovaldi http://www.drugs.com/drug-interactions/clonidine-with-sovaldi-704-0-3504-16376.html nteractions between your selected drugs There were no interactions found in our database between clonidine and Sovaldi However, this does not necessarily mean no interactions exist. ALWAYS consult with your doctor or pharmacist. Clonidine is in the drug class antiadrenergic agents, centrally acting.
Avatar m tn If treatment with PegIFN/RBV alone or in combination with one of the HCV NS3/4A PIs (telaprevir or boceprevir) is initiated, the ART regimen may need to be modified to reduce the potential for drug-drug interactions and/or drug toxicities that may develop during the period of concurrent HIV and HCV treatment. The science of HCV drug development is evolving rapidly.
Avatar f tn Vertex presented information at the AASLD conference in Boston in Nov., 2012. According to this article Vertex's VX-135, an oral nucleotide, demonstrated a median 4.54 log 10 reduction in HCV RNA after dosing once daily for seven days in treatment naive patients both w/ and w/o Ribavirin. Vertex will be conducting Phase 2 trials pf VX-135 combined with simeprevir (TMC435).