Ribavirin dose reduction

Common Questions and Answers about Ribavirin dose reduction

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Avatar m tn I was wondering any information you might have regarding svr and the ribavirin dose reduction (i did see a study regarding monotherapy with a viral load of less than 100,000 and genotype 2 here is the link http://www.ncbi.nlm.nih.gov/pubmed/19084937 any insight will be greatly appreciated.
Avatar n tn If your hgb continues to drop rapdidly you may have to dose reduce until the Procrit starts working but that will prevent future riba dose reductions. You are in wk 32 and dose reduction is not as critical if as it would be prior to becoming UND.
Avatar f tn fran; I have linked some info below you may be intesested in.however as you may notice from this article there are no mention of what stage of fibrosis the patients had. If you are late stage or possiby chirrotic the reduction may have more relavance as it seems overall patients with advanced fibrosis would have somewhat less desirable results than one with no or mild fibrosis given study data Good luck.. Will http://www.hivandhepatitis.
Avatar n tn My doc told me that any ribavirin reduction would clearly reduce my chances of clearing so I got Epogen and stayed on 1000mg/day of ribavirin. He did reduce my interferon 25% at week 30 because of chronic low WBC and low neutrophils. He said after 30 weeks, an interferon reduction would not reduce my chances of clearing. I'm currently on week 39/48.
Avatar f tn I had a rib a dose reduction after about 4 weeks. I started at the normal dose and most of the time was only able to take 600 mg. Had severe anemia and had transfusions to help my hemog rise. Was in the clinical trial for vertex phase 3. Got my results recently and was undet. At 4 weeks and almost 2 years later still undetected. BTW, was in the placebo group. I worried the whole time I wouldn't be svr.
3093770 tn?1389742726 i was on the reduction for about 2 weeks. I also got 3 pints of blood. dose reduction is the first choice. my platelets and HGB both went back up and I was able to go back to my normal dose. the important thing is to stay on the full dose of Incivek and finish the 12 weeks. your counts will probably go up and they will resume your normal dose. hang in there and try not to worry too much.
1280753 tn?1367761532 Are they having you take it 80,000 at once or two doses a week at 40,000? A one-week dose reduction of ribavirin after Week 12 has no impact so for this week, breathe easy. The impact of dose reductions beyond that are based on the length and amount of dose reduction. You've got some room yet with the aim being to get back to normal as soon as possible. I got hit with a riba dose reduction at Week 13 so I understand the concern.
5045042 tn?1365893700 ​If a patient has a serious adverse reaction potentially related to peginterferon alfa and/or ribavirin, the peginterferon alfa and/or ribavirin dose should be reduced or discontinued. Refer to the peginterferon alfa and ribavirin Package Inserts for additional information about how to reduce and/or discontinue the peginterferon alfa and/or ribavirin dose http://www.drugs.com/pro/victrelis.
Avatar m tn Hi. Welcome "Will reducing ribavirin only 1/3 into the treatment also reduce the chances of the treatment sticking?" In a word YES. Unfortunately. In the one study that was done with reduced ribavirin SVR was reduced from 71% for those who treated with weight based ribavirin to 55% for those who treated with only 600 mg of Ribavirin. (NOTE: No study has been done where changes in ribavirin dosage has occurred during a trial.) Here is an additional note from the study...
Avatar f tn Co J Viral Hepat. 2009 Jun 22. Ribavirin dose reduction raises relapse rate dose-dependently in genotype 1 patients with hepatitis C responding to pegylated interferon alpha-2b plus ribavirin. Hiramatsu N, Oze T, Yakushijin T, Inoue Y, Igura T, Mochizuki K, Imanaka K, Kaneko A, Oshita M, Hagiwara H, Mita E, Nagase T, Ito T, Inui Y, Hijioka T, Katayama K, Tamura S, Yoshihara H, Imai Y, Kato M, Yoshida Y, Tatsumi T, Ohkawa K, Kiso S, Kanto T, Kasahara A, Takehara T, Hayashi N.
Avatar f tn We don't know whether you are a first time treater or a previous tx failure or what...that would affect the decision you make about dose reduction. btw my hb went from baseline 15 to 10s to 9s and has been fluctuating between 9-10 ever since. I'm at week 24. I australia they don't give us rescue drugs at all.
1995824 tn?1330382649 com/hcp/anemia   In patients treated with INCIVEK combination treatment, 32% underwent a ribavirin dose modification (reduction, interruption, or discontinuation) due to anemia vs 12% treated with pegIFN-RBV alone   Evaluation and management of patients with anemia Evaluate Hematology evaluations are recommended at baseline and weeks 2, 4, 8, and 12, or as clinically appropriate Manage Ribavirin dose reductions should be used (refer to the Prescribing Information for ribavirin for its dose re
Avatar f tn com/2011/05/optimal-dose-of-ribavirin-for-chronic.html A relationship between RBV dose and response to therapy with both IFN alpha-2a and alpha-2b has been established in genotype 1 patients, who benefit from doses that exceed 800 mg/day (5, 14). When RBV is combined with PEG-IFN alpha-2a, relatively small reductions to 800 mg/day lead to significantly lower rates of SVR (5).
140622 tn?1190102529 I don't want to dose reduce if it will affect getting SVR. Now I'm very concerned. Please add any stories that might have anything to do with dose reduction of Riba. Thank you so much everybody.
Avatar m tn Hi, been reading the threads about RIBA dose reduction and associated data. My doctor said lower RIBA is not associated with lower SVR rates. But is there any information on dose reduction of INF and its effect on SVR? To be more specific if after going NOT DET on Incivek and subsequently there's a dose reduction in INF after that what effect does it have on VR and SVR?
Avatar f tn When I was on triple tx my HGB dropped as low as 101 and my hepatologist refused to give me procrit unless it dropped below 100. He also didn't even consider dropped my ribavirin from my 1000mg starting dose, but we were both less inclined to drop the dosage because I had already failed two previous treatments and was (am) cirrhotic too. It was a difficult year but I did achieve SVR. I hope you make it too!
1669790 tn?1333666195 The data shows that similar sustained virologic response (SVR) rates were achieved regardless of ribavirin dose reduction, including dose reduction to ≤ 600mg/day in a telaprevir-based treatment regimen for both treatment naïve and previously treated genotype-1 chronic HCV patients.[1] http://www.prnewswire.com/news-releases/incivo-telaprevir-svr-rates-unaffected-by-ribavirin-dose-reduction-in-treatment-naive-and-previously-treated-patients-with-genotype-1-chronic-hcv-147925655.
Avatar n tn Unfortunately, I don't believe that will be an option for me. Whenever I am attempting to take the normal dose of Ribavirin, I get chest pain and breathing problems. My recent physical, even on 4 Riba's a day, showed me to have an abnormal EKG and lung capacity at just 60%. I've had mild asthma for years, long before the Hep C treatments, so the treatments didn't cause that. I had wheezing problems with milk thistle, too and couldn't take that.
Avatar n tn Has anyone ever had dose reduction of Pegasus and still being SVR or EVR? My doc suggesting to reduce dose on fifth week of Tx from 180 to135 for ANC 704 and no neupogen, because neupogen causes sides also---that is his argument!???????? Honestly, I am afraid! What do you think guys? OR may be I am overdosed, my weight only 100 lbs and Height 5.4, then it is a good thing- I need child dosing? OR…………… I can not think of anything else, but I am afraid not to respond on lower doses! Please help!
789911 tn?1368640383 I'd ask for Procrit rather than dose reduction. I may be wrong but my doctor feels that reducing ribavirin would possibly jeopardize an SVR and cause a relapse.
577132 tn?1314270126 Shiffman, MD Impact of adverse events and dose reduction As opposed to interrupting or prematurely stopping ribavirin, which enhances breakthrough and relapse, recent data suggest that merely reducing the dose of ribavirin in response to adverse events does not significantly affect these milestones, and therefore has little impact on the SVR.
Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar f tn A patient told me his doctor lowered his ribavirin dose to 4 per day but he didn't say after how many weeks he did it.
Avatar m tn This not only can dramatically lower quality of life on treatment, but it can put the entire treatment at risk due to the possiblity of riba discontinuance or dose reduction. So if you're concerned about the riba -- and especially if you're over 50, male, have any kind of cardiac history, and/or a low pre-treatment hemoglobin level -- then I'd talk to your doctor about starting Procrit either at the beginning of treatment or even a couple of weeks before.
Avatar f tn That said, my guess is that -- and again given my RVR -- even he would not have minded some dose reduction at week 41. And in fact, I seriously considered a dose reduction around that point as I was then hitting one of many valleys during treatment. I didn't end up doing it, but I was very close. My opinion, and I'm certainly not a doctor, is that if you had a good viral response it's probably okay to drop the riba a little toward the end of treatment.
151263 tn?1243377877 Ribavirin dose reduction had a minimal impact on SVR in patients who achieved rapid virological response, defined as undetectable HCV RNA after 4 weeks, even when they received less than a 60% cumulative ribavirin dose. In contrast, SVR was reduced markedly in patients who had ribavirin dose reductions and did not achieve rapid virological response.
Avatar f tn If I were in your position, I'd try and get a consult right away with a liver specialist (hepatologist) to review your case, especially the dose reduction. Meanwhile, you might call your doctor and ask if you could try the Procrit first before reducing the dose. Do you know your hemoglobin numbers both pre-treatment and current? Also what is your genotype and what stage liver damage do you have and how much do you weigh?
310500 tn?1227304634 I was 100% complient, so it was not because of dose reduction. Is there something I can do with them? Give them to the doc, return them, give them to some non-profit org? I know they are very expensive and it seems like such a waste to discard them. If anyone has suggestions, please let me know. I will see the doc soon for my EOT results, so I also planned to ask him.