The progesterone does help with sleep improvement
and calmness, relief of anxiety
and immune function improves,
allergies tolerance improves
and cortisol/adrenals improve, but bio estrogen (a combo of all 3 estrogen's created by a compounding pharmacy) helps with joy, and energy, voice, and the itching and lubrication, (for me anyway) the bio testosterone cream helps with energy, gumption, and some drive. I read that estrogen dominance can interfere with thyroid function, per Dr. Lee.