can take 12-18 months to get fully out of your system. I was on it for 5 years. 4 months after I got off it, I started feeling pregnant. I was puking, smells made me sick, dizzy,boobs hurt, tired, achey, headaches, and wasn't getting my period. After catscans and ultrasounds, they figured out that I wasn't ovulating because of a cyst on my ovary caused by the depo and all my symptoms were my body going through withdrawl from the drug.