There are three different COX-2 inhibitors currently available to the public– Vioxx,
Celebrex and Bextra. COX-2 inhibitors have been associated with some
liver dysfunction, although not as commonly as other NSAIDs. Recently, Vioxx has been removed from the market due to heart-related problems. Celebrex and Bextra are currently being investigated for similar heart-related toxicities.
It is recommended that people with liver disease avoid using all NSAIDs.