ribavirin molecular weight

The empirical formula of ribavirin is C8H12N4O5 and the molecular weight is 244.2. Ribavirin is a white to offwhite powder. It is freely soluble in water and slightly soluble in anhydrous alcohol. COPEGUS (ribavirin) is available as a light pink to pink colored, flat, oval-shaped, film-coated tablet for oral administration.

Ribavirin Mode of Action in Chronic Hepatitis C: From Clinical Use Back to Molecular Mechanisms Wolf Peter Hofmann; Eva Herrmann; Christoph Sarrazin; Stefan Zeuzem Authors and Disclosures Published: 12/08/2008 ".....Despite the presence of conflicting results, accumulating data from several in vivo studies support the concept of ribavirin-induced HCV mutagenesis as a possible mechanism of action in patients with chronic hepatitis C. However, several precautions should be taken.

gov/pubmed/1695539?dopt=Abstract), (and assuming a drop in VL no doubt) Finally ribavirin metabolism involves several cytochromes. but primarily 2D6 and 3a. Here I would focus on the cyp 3a, because the telaprevir or boceprevir are also reliant on this cytochrome. Meaning this cytochrome will have plenty to do while you are treating. My SUGGESTIONS to the patients, and the high risk or late stage patients especially would be 1.

The documents for your trial don't say what the dosages for SOC are. I would ask what the ribavirin dosage is and ask if it's weight-based. I am in a trial myself right now but if the ribavirin dosage wasn't weight-based, I wouldn't have gone in it. I'm wondering if you've had a biopsy and what the results were? I'm also wondering what your viral load is...do you know this?

[15,16] Our group conducted a randomized, open-label phase III study to directly compare weekly peginterferon alfa-2a with 2 different doses of biweekly albinterferon alfa-2b (900 and 1200 μg), all of which were administered with weight-based ribavirin for 48 weeks (Capsule Summary).[17] This pivotal study included 1323 treatment-naive patients with chronic genotype 1 HCV infection.

They are now using weight based dosages as opposed to the old school thinking that geno 2's & 3"s should take only minimum dosage of 800 mg. You need the riba agatha. Sides will be what they are and one more pill isn't going to make much pr any difference in that respect but it will make a significant difference in reaching SVR. Being overweight is one of the factors they determined effects the odds of reaching SVR.

In the majority of cases, for the treatment of hepatitis C ribavirin is used alongside interferon. Ribavirin is ineffective against hepatitis C on its own. It comes in 200mg pill or capsule form and is taken orally, twice daily, with the dose being dependent on patient weight and genotype.

Hepatitis C Virus Infection: Molecular Pathways to Insulin Resistance. I just ran across this article and found it extremely educational and enlightening. Therefore I wanted to share it. It is in PDF format so I cannot copy and paste, but here is the link: http://www.virologyj.com/content/pdf/1743-422X-8-474.pdf In addition, here the link to another excellent article on HCV and Insulin Resistance: http://www.smw.ch/docs/pdfcontent/smw-12765.

He calls this molecular mimicry and says that this happens to people predisposed to having MS. I knew that the body attacked itself, but didn't reallize it was because it saw the myelin as a section of a bacteria/virus. I know a lot of you have had EBV and might find this interesting. OR, maybe I was the only one who hadn't put it all together--lol!

Studies with Victrelis showed the patient was given weight-based ribavirin (600-1400 mg/day orally divided twice daily. At 114 lbs 800 mg of ribavirin would be in range but if you tolerate 1000 mg that it all the better and at this point I don't think you're being over prescribed. It's important to get that viral load down during the first 4 weeks and ribavirin stops the virus from replicating.

I'm on weight based ribavirin, doing the incivek. Not sure about kilograms, I weigh 155 pounds , so I'm on 1000 mg per day. 3 in the morning, 2 @ night. Here's a few charts for weight based geno 1's. 65 kg – (143 lbs) 800 mg/day 65-85kg (143-187 lbs) 1,000 mg/day 86-105 kg (189-231 lbs) 1,200 mg/day 106-125 kg (233-275 lbs) 1,400 mg/day http://www.hivandhepatitis.com/hep_c/news/2011/0125_2010_b.

"On the flip side to all the fat lovers myself included , you will very likely gain weight if you stick with a high fat diet for a year and if you gain weight your Riba mg per bodyweight kg concentration will decrease. " Nobody is suggesting an overall high fat diet. While I was pretty religious about eating a high-fat food with my ribavirin, I lost weight though not much while on treatment. Once again, it's using some discretion as to what type of fat you include and how much.

I had my 2nd FNA two weeks ago after my first one came back with hurthle cells and suspicious. They sent my 2nd biopsy for molecular testing and my results came back as suspicious again. So I'm meeting with an endo surgeon next week. If both biopsies were suspicious AND the molecular testing was suspicious I'm assuming it means if my nodule isn't cancer now that it will be in the future. Is this a correct assessment?

I take 1000mg a day - 3 in the morning - 2 at night. I eat a little something with both doses to make sure tummy doesn't get upset. I only weigh around a 117 lbs and so far haven't had any problems with anemia, weight loss or weight gain. My ANC and platelets tried to tank a few times but that's about it. I had to adjust my sleep over the last 12 wks. I've never been a sound sleeper so it wasn't any big deal when i slept just a few hours.

Summary of Key Conclusions * Dosing according to glomerular filtration rate (GFR) may be preferable to weight-based ribavirin among ribavirin-treated HCV genotype 1/4 patients with poor renal function * Poor renal function (low GFR) associated with o Lower sustained virologic response (SVR) rates o More adverse events o Possibly due to nonoptimal ribavirin dosing * GFR varied according to sex, age, and genotype but not according to weight or body mass i

I am in a trial that will be comparing ribavirin dosing, weight based compared to concentration controlled based on AUC 0-12 after first dose. http://clinicaltrials.gov/ct2/show/NCT01097395?

If you are not on a weight based Ribavirin dose, you may wish to discuss getting on a weight based Ribavirin dose with your doctor. Also, depending on your fibrosis level and depending on when you do reach Undetected status, you may wish to discuss treating longer than 24 weeks. Treating for 48 weeks may be of benefit to you. (See below.

Of note, within the weight-based ribavirin group, SVR rates were consistent across all weight categories, whereas SVR significantly decreased with increasing weight in the fixed-dose group (Figure 5). Weight-based ribavirin dosing could be considered for those patients that may be more difficult to treat due to underlying host characteristics such as obesity or advanced fibrosis.

DATE Molecular Test Result Genotype 18/12/2012 HCV RNA <50 IU/mL 2b 25/10/2012 HCV RNA <50 IU/mL 30/082012 HCV RNA 1.9x10 (6) IU/mL I'm on injection 13 now. Doc has reduced interferon to 135mm and ribavirin to 3 pills per day.

Ribavirin molecular weight

Common Questions and Answers about Ribavirin molecular weight

rebetol