nausea, fatigue, breast tenderness, headaches, etc... I once had the same experience that you've described while I was on Depo. I was convinced that I was pregnant, so I went to my doctors office to take a blood test to get a more accurate answer (hpt's all said negative). It turned out that it was the Depo causing these symptoms. Unless you've already done so, I would suggest speaking with your doctor/gynecologist about how you're feeling and ask about what they advise...