This is a potential concern because the drugs in Truvada – tenofovir and emtricitabine – are active against HBV as well as HIV.
HIV and HBV are spread through some common transmission routes, including sexual transmission, vertical transmission (mother to child) and via multi-person use of injection equipment.
i really dont understand why use of truvada which is simply tenofovir plus ftc in one pill, tenofovir is the most potent drug against hbv replication and has no resistance so truvada has meaning as a business way to make money from patients with only side effects added to patients, truvada is more toxic on kidneys than tenofovir monotherapy
the only thing that may justify your doctor is the need to suppress hbv very fast in weeks instead of a couple of months but 151000iu/ml maybe suppressed in
Most participants in the study were Asian and the average age was 33. Nearly all were HBeAg-positive and had HBV DNA levels at around 10 million IU/mL. Sixty-four patients were treated with tenofovir (300 mg daily) and 62 were treated with the combination pill containing tenofovir (300 mg) and emtricitabine (200 mg).
So I had a discussion with my doctor yesterday regarding the recent elevation in my AST, ALT ( about 1.5 x ULN). I am LAM resistance, on Truvada for almost 2 years now. Everything else (HBV DNA undetectable, ultrasound ok, CBC, fibroscan + all other stuff i have no idea) came back normal. AST + ALT was in normal range all the time but 3 months recently have been up a bit.
She advised me to continue monitoring my condition and warn me about possible resistance.
no i meant you get hbv and hdv at birth, when older even if hbv is present hdv is cleared, we also have a member here with cleared hdv and chronic hbv but again it is so rare that studies are so few who knows how really reliable
while hbv+hdv is cleared as adults and not infective at all without hbv
Hi Klamba,
Could it also be that you are negtiive for hbv dna? Just like the other hepatitis b indicators are negative in your case? I think you are worrying unnecessarily about hepatitis b, when you don't have it. Please try to forget about hbv and focus on your hiv infection by trying to keep a healthy life style.
I hope the other more knowleageable commenters like Stef would give you their advice.
absolutely off label, one might even think about truvada plus immune globulins plus vaccine since truvada has been used after transplant to prevent reinfection and it worked on 100% persons
it would be interesting to see a study on antivirals to prevent hbv after exposure but i guess it would be too difficult to make such a study and especially to find the subjects so transplantation might be the closest to this situation considering transplant recepients have a worst situation because they hav
I was given Truvada (Prep) for treatment. I have taken it daily for 4.5 years and my viral load down has remained dormant and the HBV undetectable. Recently, I moved to a new city and my new job does not offer insurance. I cannot afford the medication without insurance as it is very expensive. Is there a chance my body could have rid itself of HBV during these 4.5 years?
Do you recommend the truvada over the viread or baraclude? If while being switched from Hepsera to truvada is there a risk that the Hep B could become active? Also , the Hepatitis B DNA is currently undetectable and the Hep B Surface AG is currently negative (both prior to transplant as well as post transplant, so far ) what are the chances that the Hep B could become active again once the Hbig infusions are stopped? Thank you.
1 - reactive) is good because low (in cronic hbv is always in the thouzands) although i am more familiar with iu/ml or s/n, when you reach 10iu/ml the possibility to have negative is very high and it is also very important to monitor if it declines from base line to 24 and 48 weeks or stays about the same
i have seen a patient cleared hbv+hdv in 10 months interferon+truvada combo but truvada has more sides than etv and probably inf+entecavir is the about the same
i guess interferon is the most
Currently DESCOVY 25mg TAF plus 200mg emtricitabine is alead approved for hiv in the USA and canada. It could well be used for hbv, most likely at 1/2 tablet a day for hbv for patients who do not tolerate viread.
the emtricitabine. ..also called FTC, is also used in TRUVADA at the same dose, which is frequently used by hepatologists for patients with a suboptimal response to viread.
I am diagnosed with chronic Hep B and on Truvada for more than 5 years now. The disease is under control and virus is almost undetectable.
I am going on business trip to a country where Hep B vaccine is a requirement for the visa. Can I take Hep B vaccine? Will it cause me any harm? Will vaccine interact with Truvada and have any side effect?
Any advice will be greatly appreciated.
Thnaks.
Hi,can anyone tell me what are the medical options remaining after being resistant to both lamivudine 100 and entecavir 0.5?Will tenofovir 300 alone or ETV+TDF or any other Combo work?Please share your views?
I'm taking Truvada now for almost 2 years (Undetectable HBV DNA, e antigen still positive, lam resistance).
Can I switch to Baraclude? It will be easier for my budget since it cost way less coz' I'm planning on moving back home. I'm in the US.
Any possible resistance or virus breakthrough if I decided to switch therapy?
check hepatitstechnologies products, todd had cirhosis due to hbv+hcv and reversed cirrhosis totally from 2004 to now, so whatever happens you can block all liver damage especially if your liver has much less damage than cirrhosis
make sure you have acess to a fibroscan because this is the only tool to monitor liver damage.
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