tacrolimus use in dogs

Since I was on tacrolimus only(as Mycophenolate causes TLC to go down in two occasion), sirolimus 1mg is started along with reduced tacrolimus(2mg BD, Tac level ~4.5). But the creatinine is still high(1.8). It seems some side effect of Sirolimus is also coming as the TLC is 3400 and platelet is 80,000. What do you suggest to bring creatinine under control? What is the way to determine the exact required dose of tacrolimus?

I was told he will have to wear a cone for 10-14 days and it is vital to keep the eye protected while it heals. Some bigger dogs will dig with their cones in the snow-I live in Minnesota. Mike likes to bury his face in the snow, so I'm going to be watching closely. I am home, and don't mind doing some drops daily, but wish not to annoy him by constant checking and cleaning a re-moisturizing. He will probably enjoy getting a Charlie Bear when needed more that a drop or ointment.

currently there is no data on its use in the post-liver transplant setting. i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.

Today I filled a prescription for a 45 gram tube. My problem is that the prescribing information from the manufacturer says to use the product for two weeks, but the doctor did not put any time period on the prescription (just says to apply twice a day). Since I have already been using it for a week from the sample, and the condition has cleared up, should I stop using it after one more week, or just continue using it indefinitely or only when there are flare-ups?

Both eyes had a schirmer test of 0. (interestingly though, a few days before at the vet, the schirmer test was 12 in both eyes). Now 6 weeks later, the right eye has a 6 and the left eye still has 0. The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus.

In 27 centers (33.8%) the immunosuppression protocol used in HCV differed from non-HCV patients. Tacrolimus-based immunosuppression is utilized in 70 centers (86.42%). Triple therapy using tacrolimus, mycophenolate mofetil and steroids is the most common regimen (41%). Six programs (7.4%) use steroid-free protocols. In nine centers (11%) steroids are discontinued within a week, 56% within 3 months, and 98% within the first year.

BUT, the Collidal Silver (Purchase at a Health food store) worked wonders! I still use it if I see any goop forming in his eyes. Now the eye drops: The very best product I have found for Dry Eye is called I-Drop Vet Opthalmolic Solution (20 Dose Pipettes). My Vet is who orginally gave me samples of these. She does not carry it so I order online. I have only found two places that carry it in the states. The company is out of Canada and have for years made human eye care products.

I suggest you look up some articles on crate training and have your husband read them. We are not talking in humane crating here. He probably has visions if puppy mill dogs. Many of us here are experienced and "humane" dog people. Dogs are basically den animals. All my dogs have usually gone in their crates on their own to nap, my little one is in her crate now. I leave the door open. If your dog is ill or injured, the crate comes in handy.

You can get yourself prescribed antibiotics like testracyclines which help in decreasing the inflammation a bit. Tacrolimus combined with oral antibiotics also helps a lot. You can discuss these treatment options with your dermatologist. I hope it helps. Take care and regards.

His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys? Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe? Sir ,will wait for your kind reply. Thanks.

Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful. If still the symptoms do not improve then please get a clinical examination done by a dermatologist. I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.

I use the same med for my Cavalier King Charles Spaniels eyes, I have to use it the rest of her life. She is blind in one eye and almost blind in the other. But I understand that the dryness will just get worse and worse without the meds everyday and they did not paint a pretty picture. I don't think you can tell on a daily basis but you need to keep using it.

1 prescribed Triamcinolone cream and told me to use it one week on and then take a one week break for several months. I did that for two months and nothing improved. Another Dermatologist thought my immune system caused the reaction and prescribed Tacrolimus ointment...told me to put it on until the color came back. I did that for 3 months and didn't notice any significant change....only occasional peeling of the skin next to the head of my penis!

like myself who is also a (human) medical technician (nurse) said that he has had success with Benadryl Topical liquid on his dogs. I know the fact that it is safe/recommended for human use is not proof it is safe or effective on dogs. Still I'd like to give it a try. On the ears there is no way he can lick/ingest the stuff, on the feet he may get some ingested and perhaps that is a different issue.

Drink plenty of water and take multivitamin supplements and do not apply lipstick or other cosmetic products for some days. Use a humidifier to moisturize the air in your home and apply shea butter or Vaseline on your lips. Treatment is by topical steroids or oral therapy of corticosteroids in severe cases.Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful. Hope it helps.

there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.

AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.

t be coming from the phenobarbital. The usual side effects in canines from phenobarbital use are lethargy, polydipsia (increased thirst), polyuria (increased urination), polyphagia (increased appetite), anxiety and weight gain. From the symptoms I think your vet is probably right on the money with the diagnosis of a mass in the brain, but I doubt that the tremors signify pain because you said they are of short duration.

Tacrolimus use in dogs

Common Questions and Answers about Tacrolimus use in dogs

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