Can tacrolimus eye drops and Cyclosporine ointment cause cancer in dogs? My precious dog, baby and best friend was diagnosed just last week with Transitional Cell Carcinoma in his bladder. It is a rapid growing cancer. I am completely heartbroken and am wondering if there was something I could've done to prevent this. He has been on these two eye medications for about a year. His name is Duke and he is a beautiful tri-colored collie and is a little over 10 years old.
Since I was on tacrolimus only(as Mycophenolate causes TLC to go down in two occasion), sirolimus 1mg is started along with reduced tacrolimus(2mg BD, Tac level ~4.5). But the creatinine is still high(1.8). It seems some side effect of Sirolimus is also coming as the TLC is 3400 and platelet is 80,000.
What do you suggest to bring creatinine under control?
What is the way to determine the exact required dose of tacrolimus?
Both eyes had a schirmer test of 0. (interestingly though, a few days before at the vet, the schirmer test was 12 in both eyes). Now 6 weeks later, the right eye has a 6 and the left eye still has 0. The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus.
His cretanine is almost 1.4 or around. My question is that should he continue his TACROLIMUS tablets or should switch to some other tablets which are safe for kidneys?
Secondly , in my sorrounding there is an opinion that lowering the TACROLIMUS dose also let the liver enzymes to increase? Do you favour such opinions as my father has lowered his tacrolimus dose to keep his kidneys safe?
Sir ,will wait for your kind reply.
Thanks.
I was told he will have to wear a cone for 10-14 days and it is vital to keep the eye protected while it heals. Some bigger dogs will dig with their cones in the snow-I live in Minnesota. Mike likes to bury his face in the snow, so I'm going to be watching closely. I am home, and don't mind doing some drops daily, but wish not to annoy him by constant checking and cleaning a re-moisturizing. He will probably enjoy getting a Charlie Bear when needed more that a drop or ointment.
there are prograf assistance programs that the company offers. If this is not feasible than using other cheaper medications such as verapamil for example for HTN for example will alllow much lower doses of prograf to be used (it delays metabolism of the medication) and thus it comes out cheaper.
AS I HAVE SUFFERED BREATHLESSNESS AND WALKING PROBLEMS,I HAVE BEEN TAKEN OFF TACROLIMUS AND PUT ON NEORAL-YET THERE IS NO IMPROVEMENT IN MY CONDITION.IS THERE ANY OTHER ANTI REJECTION DRUG THAT YOU WOULD RECOMMEND (I HAVE HAD A LIVER TRANSPLANT RECENTLY)? IN YOUR EXPERIENCE,CAN MY SITUATION BE IMPROVED?THANKS.
and the Creatinine level at that was 1.5 - 1.6. The doctor reduced the tacrolimus dose to .5 mg morning and evening and since then the Creatinine level is slowly increasing. It is now between varying between 2.1 and 2.4. The TAC level is also low and reduced from 4.5 to 3.4 to 2.4 when last checked 2 months ago. Had a biopsy 2 months back and the report was OK.
Pl suggest.
currently there is no data on its use in the post-liver transplant setting. i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
50 yo male with kidney transplant in March, 2011 from a cadaver, donated kidney.
Tacrolimus 2.5mg BID
Mycophenolate 500mg AM , 250mg PM
No after affects post transplant, no illnesses.
Maintaining a healthy weight and on a vegetarian diet.
All other lab levels are WNL.
My tacrolimus level is 4.2 after 4 months of liver transplant, Is it dangerous? what should i do?
Treatment is by topical steroids or oral therapy of corticosteroids in severe cases. Topical creams like tacrolimus ointment (Protopic) and pimecrolimus cream (Elidel) are also useful.
If still the symptoms do not improve then please get a clinical examination done by a dermatologist.
I hope it helps. Take care and please do keep me posted in case you have any additional doubts. Kind regards.
What is considered "high blood pressure" and when does it become a concern??? My typical blood pressure is in the low 120's/low 130's however, lately its been in the mid140's/low 150's. Does this happen after transplant (3 months post transplant)? Should I be concerned?
Does Prograf cause tremors? And...can these tremors be contributing to making a person feel tired and exhausted???
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