At 6 months of starting TDF/LMV combination, HBV DNA levels became undetectable (detection limit, 400 copies/ml) in
four of six patients. Within 12 months, HBV DNA levels
became undetectable in
all patients, and ALT levels were normalized in four of six patients. These responses persisted up to the end of the observation period (median duration 16.5 months, range 6-21 months). The Child-Pugh scores improved in two of three patients with hepatic decompensation.