Do you have a family history of duodenal ulcer
. Duodenal ulcer
can also be caused by alcohol, nicotine,caffeine,tobacco, taking NSAID's aspirin, brufen e.t.c. The most common cause is the infection with H.Pylori. Does the pain cause you to wake up in the midnight. About fifty percent of patients with duodenal ulcers awake during the night with pain, usually between midnight and three a.m. Duodenal ulcers respond well to treatment, so relax and get yourself checked.