Ribavirin wikipedia

Common Questions and Answers about Ribavirin wikipedia


Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
233616 tn?1312790796 In comparison with corresponding plasma values of ribavirin following a high-purine meal, Cmax, AUC0-144 and AUC0-∞ of ribavirin following a low-purine meal were 136% (90% confidence internal [CI]: 120%-155%), 134% (90% CI: 118%-153%), and 139% (90% CI: 120%-159%), respectively. This study indicates that dietary purines have an effect on ribavirin absorption. Dosage regimens of ribavirin might need to be adjusted according to the purine content of the meal.
1547916 tn?1294284211 here in the States, the cost for 24 weeks pegylated interferon/ribavirin, if purchased by cash out of pocket would cost (roughly) USD $14,000. (AUD $13,675). The interferon requires refrigeration; it is shipped overnight in cold-pack cooler containers.
Avatar m tn Ribavirin is also a teratogen in some animals species and thus poses a theoretical reproductive risk in humans, remaining a hazard as long as the drug is present, which can be as long as 6 months after a course of the drug has ended. It has nothing to do with the menstrual cycle. It has to do with how the presence of ribavirin in the body can impact the development of the baby.
1084115 tn?1385232189 The mean half-life for multiple doses in the body is about 12 days, but very long-term kinetics are dominated by the kinetics of RBCs (half-life 40 days). RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen.
1838299 tn?1403496143 If you doc reads the ribavirin package insert directions it says that for anemia the standard protocol is to reduce ribavirin to 600 mg per day if hemoglobin <10 g/dl, first. If < 8.5 g/dL interrupt dose. Then see if hemoglobin level rise. In the clinical trial most patients did rise. Only 4% stopped treatment owing to anemia. 1. The proper protocol is to reduce ribavirin to 600 mg when hemoglobin is less than <10 g/dl.
Avatar n tn ribavirin and interferon. Interferon is a once-a-week injection. Ribavirin is little pills taken twice daily. Interferon can give flu-like symptoms as side-effects, though for most of us those aren't too bad after the first few weeks. Ribavirin has a variety of side-effects, including anemia (low red-blood-cell count). One of these two (I'm not sure which) sometimes also causes low white-blood-cell count. Neupogen helps the body increase white blood cell count.
3867523 tn?1348953285 Anemia has been reported with peginterferon alfa and ribavirin therapy. The addition of INCIVEK to peginterferon alfa and ribavirin is associated with an additional decrease in hemoglobin concentrations. A decrease in hemoglobin levels occurred during the first 4 weeks of treatment, with lowest values reached at the end of INCIVEK dosing. Hemoglobin values gradually returned to levels observed with peginterferon alfa and ribavirin after INCIVEK dosing was completed.
Avatar m tn Cannabidiol (a component of medical marijuana) has been used to ease auto-immune disorders such as inflammation or arthritis. I wonder if it would be useful in mediating the side-effects of peg-interferon & ribavirin or if would more likely counteract the desired immune responses. CDB may also be useful in treating depression. CDB or cannabidiol information can be found by a web search especially on wikipedia.
206807 tn?1331939784 I found it: "Be careful about what you read on wikipedia." http://www.medhelp.org/posts/Current-Events---/Muslim-Statistics-Slavery/show/2627054 That thread was in relation to slavery, but since that comment was taken to heart on one subject and not disputed we should assume that it holds true for all subjects... is that not correct?
Avatar m tn htm On the other, without a certain level of circulating Fe we're toast as it's an essential cofactor for hemoglobin's oxygen-binding function. Wikipedia has a very nice article on HGb - http://en.wikipedia.org/wiki/Hemoglobin note the Fe ions coordinated by the heme group. Ribavirin accumulates in Hgb-containing red blood cells and kills them off (hemolytic anemia) which can be remedied by epo ; however Hgb without the trace amount of necessary iron can't do its job.
Avatar f tn The current drugs are interferon and ribavirin, and they aren’t designed to treat patients with cirrhosis that are experiencing decompensation, unfortunately. There is a new drug on the market that might help increase his platelet count; it’s generic name is eltrombopag; I think the brand name is Promacta. It’s not ‘labeled’ for Hep C patients, although we have a couple of patients in here that are using it for this purpose.
Avatar n tn Other Viral Activities Experimental data indicate that ribavirin may have useful activity against many viruses of interest, including avian influenza, hepatitis B, polio, measles and smallpox. Ribavirin is the only known treatment for a variety of Viral hemorrhagic fevers, including Ebola virus, Marburg virus, Lassa fever, Crimean-Congo hemorrhagic fever, and Hantavirus infection.
1118884 tn?1338596450 I have Hepatitis C and have just started Pegasys(a form of chemotherapy that requires weekly self injected Interferon and 4 pills of Ribavirin daily). I like to visit other forums, it warms me knowing that other people are getting the support they need. I just looked under Anal Cancer under the website encyclopedia called WIKIPEDIA. It is a great site, I go there for alot of answers.
Avatar m tn Peginterferon alfa-2a/ribavirin had lower incidences of depression and flu-like symptoms than standard interferon/ribavirin, whereas peginterferon alfa-2b/ribavirin and standard interferon/ribavirin had similar incidences of these AEs.
Avatar n tn The following is an excerpt from wikipedia. Ribavirin can stay in your system for quite a long time. Trace amounts could probably be detected in some people well past six months. People usually feel completely "normal" in six months or less and that is what we all look forward to. The volume of distribution of ribavirin is large (2000 L/kg) and the length of time the drug is trapped varies greatly from tissue to tissue.
Avatar f tn If he tests negative for the NS5A he should be treated for 24 week of Harvoni with Ribavirin.
1225178 tn?1318984204 Dianne, grapefruit contains compounds that can interfere with certain enzymes; I’m not positive, but I don’t think either interferon or ribavirin is on that list. Wikipedia lists these drugs as being affected by grapefruit; I don’t know how comprehensive this is though: http://en.wikipedia.org/wiki/List_of_drugs_affected_by_grapefruit It’s worth a look just in case something other than HCV drugs you’re taking is on there.
Avatar f tn My GI Doc told me & I do injections into my abdomen, I will not change the place of injections because it's working. Every Friday night I find a place around my belly button (fat) where there isn't a bruise from the previous week & inject the Peginterferon there. I would ask your doc or nurse, the butt has enough fat so I think that it'd be a great place for your injection site, but I'd still recommend asking your HCV tx ppl before you try it. Best of luck to you and your tx!!!
Avatar n tn My Pegasys nurse says : about 1 month for interferon and about 70 days for ribavirin. Ribavirin can sometimes be detected in the blood 6 months after completion of tx. I suppose everyone is different. At 6 weeks post, for me, I noticed more saliva. This showed me that the meds were dissipating.
Avatar n tn In my case I seriously doubt that treatment was the cause or a contributing factor because it has been 4 years and I haven't had any autoimmune issues or any side effects that I believe are interferon/ribavirin based. I do sympathize with your elbow problems and the Gout too. I was shocked at the pain I experienced from Gout. It was debilitating until I started the Prednisone. I hope you recover quickly and don't have another episode of either disease.
Avatar m tn So, did you have a question. Is it your belief that Methylene Blue is Ribavirin? There is no mention of Ribavirin within the application or the described study and results. What exactly brought you to that conclusion? Thanks.
Avatar n tn I wouldn't skip my ribavirin. I'd take it as usual and then talk to my doctor as soon as possible about the dizziness. You should have it checked out by him. Feeling dizzy for me during tx is somewhat routine. I don't know what it means but I made the decision to live with it and adhere to my meds. So far, I've survived 46 weeks on tx. Although there was a dramatic scene where I lost consciousness in a public place, I keep rolling along. It's hardest at the beginning, when it's a novelty!
Avatar m tn this is the ONLY thing PROVEN to cure HCV when used along with Ribavirin. did you ever think you may have been in the accute stage of the disease and cleared it on your own? Or the test was a false positive. This does happen to around 15% of people with HCV.
220090 tn?1379170787 "RETROVIRUS From Wikipedia, the free encyclopedia A retrovirus is any virus belonging to the viral family Retroviridae. They are enveloped viruses possessing an RNA genome, and replicate via a DNA intermediate. Retroviruses rely on the enzyme reverse transcriptase to perform the reverse transcription of its genome from RNA into DNA, which can then be integrated into the host's genome with an integrase enzyme. The virus then replicates as part of the cell's DNA.
476246 tn?1418874514 Is Peginterferon chemotherapy? Is Ribavirin oral chemotherapy? I seem to be getting different results on this when I try to look it up. I have not been able to get any concrete statement anywhere on the net.
Avatar f tn must be her memory problems. I also got fibromyalgia, cfs, gut problems..which is probably mostly due to the ribavirin, memory problems especially short term, vision is worse off, panic attacks, teeth problems, headaches like I got on the treatment, mild stroke like 'things' that upon testing and ct's and mri's show no strokes and brain looks normal, intermittent ataxia..loss of muscle control, heart problems, chemical, drug...which keeps me from taking most pharmy drugs that may help...
1913502 tn?1330391792 A Multicenter, Open-label, Randomized, Duration Finding Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Following Oral Administration of PSI-7977 in Combination With Pegylated Interferon and Ribavirin in Treatment-Naive Patients With Chronic HCV Infection Genotype 1,4, 5, or 6