Ribavirin triphosphate

Common Questions and Answers about Ribavirin triphosphate

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Avatar f tn Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material. Though not effective against all viruses, ribavirin has important activities against influenzas, flaviviruses and agents of many viral hemorrhagic fevers. Ribavirin is a pro-drug, meaning that it is a chemical precursor for the actual phamacologically active molecule.
233616 tn?1312790796 Inosine triphosphate protects against ribavirin-induced ATP loss by restoring adenylosuccinate synthase function Yuki Hitomi1, Elizabeth T. Cirulli1, Jacques Fellay1, John G. McHutchison2, Alexander J. Thompson2, Curtis E. Gumbs1, Kevin V. Shianna1, Thomas J. Urban1 and David B.
4806014 tn?1424505478 In many ways Sofosbuvir is similar to past experimental drugs that essentially mimic a ribonucleotide, selectively stalling the production of viral RNA. The problem with past drugs was that the creation of triphosphate variants -- a necessity to make the drug usable by the viral polymerase -- was way too slow.
1084115 tn?1385232189 GTP is required for translation, DNA and RNA virus transcription and RNA virus replication *inhibition of capping of viral transcripts *direct inhibition of viral RNA polymerase by ribavirin triphosphate *modulation of immune response resulting in a reduction of immune-mediated tissue damage *ribavirin triphosphate is utilized by viral RNA-dependent RNA polymerase and causes lethal mutagenesis of the viral genome
1118724 tn?1357014191 Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction. Antiviral Activity in Cell Culture In the stable HCV cell culture model system (HCV replicon), ribavirin inhibited autonomous HCV RNA replication with a 50% effective concentration (EC50) value of 11-21 mcM. In the same model, PEG-IFN α-2a also inhibited HCV RNA replication, with an EC50 value of 0.1-3 ng/mL.
7510956 tn?1411675017 Ribavirin has direct antiviral activity in tissue culture against many RNA viruses (such as HCV). Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
Avatar n tn I just read that inosine triphosphate pyrophosphatase (ITPA) deficiency is a clear risk factor for early onset of anemia during HCV treatment, necessitating that ribavirin be reduced or discontinued. The article I read was dated June 2010 and said there is no test for ITPA but that there likely would be soon. Does anyone know if a test has been developed or if there is any way to factor this variable in when choosing a treatment? Thanks.
Avatar m tn The most frequent side effect of ribavirin is hemolytic anemia, which occurs in up to one-third of patients. Ribavirin causes hemolysis because ribavirin triphosphate is concentrated by erythrocytes. ..... During treatment with ribavirin, bilirubin and uric acid levels increase in about 10%–25% of patients. These side effects disappear 4–7 weeks after discontinuation of therapy." http://www.annalsofhepatology.com/old/PDF/vol5s1/Hp06S1-19.
Avatar f tn One of the most anticipated may be the introduction of direct-acting HCV antiviral drugs, which a series of clinical trials have shown to be highly effective when combined with pegylated interferon (PegIFN) and ribavirin. Additionally, new methods of patient stratification prior to treatment not only will yield better prognostic information, but also are likely to alter therapeutic approaches regarding the potential benefits and risks of HCV therapy.
225275 tn?1276961493 //www.medhelp.org/posts/Hepatitis-C/Ribavirin-absorption-fats-and-PURINEs/show/1446708 Good Luck with that and when you understand it, please explain it to me.
Avatar n tn If it doesn't bother him with the combo of the ribavirin making him speedy he really doesn't have to cut it out. Some studies suggested that coffee is HELPFUL to us so go figure. it sounds like he's had a pretty easy ride on tx if you can just get the platelets ironed out. I hope it happens soon!
135456 tn?1301441224 Accumulation of ribavirin in the brain suggests that ribavirin is trapped within the aqueous compartments of the brain and has a greater half-life than it does in serum. Since the active intracellular form of ribavirin is ribavirin triphosphate, it is important to determine if the higher, sustained levels of ribavirin also are reflected in higher ribavirin triphosphate levels.
29837 tn?1414538248 It is known that the triphosphate metabolite of ribavirin accumulates in red blood cells and causes oxidative injury to red blood cell membranes, thereby resulting in hemolysis. Patients who develop an anemia on ribavirin therapy have a responsive reticulocytosis. However, DeFrancesci et al.
264233 tn?1216345915 pdf CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 71 • SUPPLEMENT 3 MAY 2004 S17 n ABSTRACT Hematologic abnormalities such as anemia, neutropenia, and thrombocytopenia are common during combination therapy with pegylated (or standard) interferon and ribavirin for chronic hepatitis C. Ribavirin- induced hemolytic anemia is a common cause of dose reduction or discontinuation.
419309 tn?1326506891 At week 68 of treatment, we got the call that my husband's AFP had risen to 128: the nurse was very concerned. Well, he had his CT-Scan Tuesday, and the doc says, at least for now, he's in the clear :) ... no clearly defined liver tumor. It was a tremendous relief, but the lead doc in the clinic came in and said that he was very concerned about future recurrence of hcc in my husband.