Ribavirin toxicity

Common Questions and Answers about Ribavirin toxicity


Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
Avatar m tn I am Genotype 1b and have been on Interfuron Alpha 2a Injections and ribavirin. I, was started out with 1200 mgs Ribavirin per day and my first Viral-Load reading was- (165,000,000 ) and now it is below (50 ) non-detectable !!! Then I, got Anemia, problems with hemaglobin, then after that we lowered the Ribavirin to 1000 mgs !! And then I, got problems with White Blood -Cells going low!!! so we lowered the ribavirin to 800 mgs !!!
Avatar m tn I rember back when biln 2061 was the rage and then the animal toxicity put a halt to it. The next NS3 to come was vx-950. I remember to start with vx-950 was tested for 14 days as a mono and with great results, As I remember all became undetectable in 14 days. Then the virus slowly came back after stopping. I wonder how toxic vx-950 is and what would happen if you kept taken it as mono for a long period of time.
Avatar f tn Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of viral genetic material. Though not effective against all viruses, ribavirin has important activities against influenzas, flaviviruses and agents of many viral hemorrhagic fevers. Ribavirin is a pro-drug, meaning that it is a chemical precursor for the actual phamacologically active molecule.
427265 tn?1444080036 this may be difficult due to insurance issues, as well as fairly recent black-box warnings on epoetin. Make sure you discuss and understand other forms of toxicity including host DNA/RNA issues; not much published out there about this. There was a study published in early 2005 (I believe in J. Hepatology) by K. Lindahl from Sweden, which achieved 90% SVR with GT-1 patients using very high doses of riba; up to 3600 (?) mg/day.
476246 tn?1418874514 I planning to take my morning ribavirin with my breakfast with a chunk of cheese. I am also taking krill oil, which one is supposed to take with the first meal. My question is if it is okay to take either krill oil or fish oil at the same time as the riba?
Avatar n tn showed no difference in the SVR rate in patients with genotypes 2 and 3 infections using ribavirin doses ranging from 800 to 1,200 mg daily. Thus, the issue can be narrowed to optimizing therapy for genotype 1 patients." Speaking as a SVR-hungry Geno 1, I wonder if it would be the height of idiocy to increase my daily ribavirin dosage from 1000 mg to 1200 mg? I've been taking the lower amount, according to the current weight-based regime.
233616 tn?1312790796 It has been found that higher rates of SVR could be achieved with higher ribavirin concentrations in genotype 1-infected patients. Unfortunately, the incidence of toxicity also increases with ribavirin plasma concentration.
Avatar m tn The Effect of the Addition of Ribavirin with Harvoni treatment.. With the addition of Ribavirin, Harvoni treatment time can be reduced to 12 weeks with similar to the SVR rates for 24 weeks of Harvoni used without Ribavirin! That is 12 weeks less time dealing side effects if a person can tolerate 12 weeks of Ribavirin. Plus a reduced cost of treatment. ------------------------------------------------------------------------------------ For those with HIVHCV -COINFECTION http://www.
Avatar f tn More than 1000 patients have treated with GS-5885 in phase 2 studies so far, with no signals of toxicity. The selected dose for further development is 90 mg QD. I did see someone on here that is taking the One pill tx.I just commented on there post under the GS7977 Study Patients Here! I think.I cant remember who it was,but they where undetected after 2 weeks.I will go look and see who it was and let you know. Are you getting ready to start this trial?
135456 tn?1301441224 The bioavailability of ribavirin 600 mg was decreased by ... Ribavirin (Rebetol) is a synthetic nucleoside analogue which has shown in vitro ... www.emea.eu.int/humandocs/ PDFs/EPAR/Rebetol/H-246-PI-en.
Avatar m tn 16 Ribavirin The synthetic purine nucleoside Ribavirin rapidly enters eukaryotic cells and after intracellular phosphorylation exhibits virustatic activity against a broad spectrum of DNA and RNA viruses.25 Several studies have been conducted to evaluate ribavirin monotherapy in daily doses of 600-1,200 mg in the treatment of chronic hepatitis C.26-28 While all trials consistently showed a decrease in aminotransferase levels, no virologic end-of-treatment responses were observed.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
Avatar f tn This analysis included 10 genotype 1 null responders who previously had less than a 2-log reduction in HCV RNA with a prior course of pegylated interferon plus ribavirin. All were treated with 400mg once-daily GS-7977 plus 1000 or 1200mg weight-based ribavirin for 12 weeks." ============================================ It is a deceptive headline, IMHO, that would be far better if it mentioned that the failures were past null responders, not all CHC patients.
Avatar f tn Adult Antiviral Agents/adverse effects Antiviral Agents/therapeutic use* CD4 Lymphocyte Count Female HIV Infections/complications* HIV Infections/drug therapy* Hepatitis C, Chronic/complications* Hepatitis C, Chronic/drug therapy* Humans Immunocompromised Host Interferon Alfa-2b/adverse effects Interferon Alfa-2b/therapeutic use* Male Polyethylene Glycols/adverse effects Polyethylene Glycols/therapeutic use* Ribavirin/adverse effects Ribavirin/therapeutic use* Treatment Outcome Viral Load Subst
Avatar f tn RISK OF SERIOUS DISORDERS AND RIBAVIRIN ASSOCIATED EFFECTS "Significant teratogenic and embryocidal effects have been demonstrated in all animal species exposed to ribavirin. Therefore, COPEGUS is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
Avatar f tn After researching Tramadol last week and seeing its sx I was wondering if it was contributing to the hallucinations I was having with the interferon and ribavirin. I asked the doctor if there was any other pain med I could take after doing the research and scaring myself silly and was told no. I tried weaning off of the Tramadol, but the pain is too much to bear along with the sx of the HCV therapy, so started taking it again.
Avatar n tn Unfortunately BILN 2061 was found to cause heart toxicity problems in primate (monkey) testing, so it was discontinued. No further human testing of BILN 2061 was conducted. The good news is that there are other protease inhibitors that are being tested now, which are about as effective (or even moreso) than BILN 2061 and don't have the heart toxicity problems. Vertex Pharmaceutical's VX-950, or Telaprevir, is the best thing going right now.
Avatar m tn pdf there s new data about toxicity, i didnt see it in jan 2013 when i tried ezetimibe, toxicity is extremely low: http://www.merck.ca/assets/en/pdf/products/EZETROL-PM_E.pdf acute toxicity In animals, no toxicity was observed after single oral doses of 5000 mg/kg of ezetimibe in rats and mice and 3000 mg/kg in dogs. Ezetimibe (1000 mg/kg) was co-administered with either simvastatin (1000 mg/kg) or lovastatin (1000 mg/kg) by oral gavage to mice and rats. All animals survived.
Avatar n tn I took Peg-Intron + Ribavirin, Pegasus +Ribavirin, and Consensus + Ribavirin(experimental) and each time I wound up with severe bone marrow toxicity and had to inject Procrit and Neulasta one or more times per week in addition to all the other meds. Every protocol put me into remission, and every time I relapsed within 3 months.
318582 tn?1248122151 And the drug you're probably wondering about is called Alinia. It's been recently tested in Egypt (it was added to existing interferon/ribavirin drug therapy) on genotype 4's and although the test results are a little confusing, it definitely appears to be helpful in geno 4's. Plus it appears to have virtually no negative side effects and very low toxicity, so it shouldn't add to treatment misery.
Avatar m tn She put me on Procrit (10,000 x 2 =20,000 Weekly I am also taking Peg-Interfuron-Alpha 2a and Ribavirin (1000 mgs per day) My viral load is below 50 non-detectable !! And I, am in week 23 of my 48 weeks of treament !! Before Procrit I was very Fatigued and out of breath !!! When I, took the full dose of procrit 20.000 all at once i got very sick, Vomitting, Headaches,etc. Nurse says that I am Sensitive to Meds !! So she cut the procrit dose in half !!
87972 tn?1322664839 The investigational hepatitis C virus (HCV) NS4B inhibitor clemizole demonstrated synergistic antiviral activity with the HCV protease inhibitors telaprevir and boceprevir -- meaning the combined effect was greater than the added effects of the 2 drugs used separately -- without increased toxicity, according to a laboratory study published in the July 1, 2010 Journal of Infectious Diseases.
4333925 tn?1359106042 06 times the recommended daily human dose of ribavirin). No maternal toxicity or effects on offspring were observed in a peri/postnatal toxicity study in rats dosed orally at up to 1 mg/kg/day (approximately 0.01 times the maximum recommended daily human dose of ribavirin). Treatment and Post treatment: Potential Risk to the Fetus Ribavirin is known to accumulate in intracellular components from where it is cleared very slowly.
Avatar m tn 1110-4. Interferon-alpha-2b/ribavirin-induced vestibulocochlear toxicity with dysautonomia in a chronic hepatitis C patient. Johnson K, Sargent LA, Galizio C, Ubogu EE. Source Neurology, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Avatar m tn Experts in the field agree that STAT-C drugs combined with pegylated interferon and possibly ribavirin are the future for treating Hepatitis C. Learn more about STAT-C, as well as the three factors limiting interferon treatment. by Nicole Cutler, L.Ac. A new era of medical technology is currently emerging for Hepatitis C treatment. The development of specifically targeted antiviral therapy for Hepatitis C (STAT-C) is rapidly advancing and will revolutionize the way this virus is treated.
4950316 tn?1394188185 Very little trauma and panic etc over treatment issues and side effects of triple TX (Telaprevir or Boceprevir with Interferon and/or Ribavirin). Instead, generally, people being surprised about how few side effects and so happy about the increase of their chances of SVR. I DO think the shorter treatment times have so much to do with the decrease in SX.
Avatar n tn The National Institutes of Health Consensus Conference on the Management of Hepatitis C1 had just officially recognized the combination of peginterferon-α and ribavirin as the standard of care for hepatitis C, and little could be offered to the approximately 20% of HCV genotype 2- and 3-infected patients or to the 50% of genotype 1-infected patients who were not clearing the infection with this combination.
Avatar n tn Use with Ribavirin and Peginterferon Alfa Ribavirin may cause birth defects and/or death of the exposed fetus. Extreme care must be taken to avoid pregnancy in female patients and in female partners of male patients. Ribavirin therapy should not be started unless a report of a negative pregnancy test has been obtained immediately prior to initiation of therapy.