Ribavirin thrombocytopenia

Common Questions and Answers about Ribavirin thrombocytopenia

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895634 tn?1283992810 May 13, 2010 WASHINGTON -- Drugmaker GlaxoSmithKline terminated a trial of eltrombopag (Promacta) in liver disease patients due to an increase in thrombotic events in the treatment group, the FDA said. Six patients (4%) taking eltrombopag had a thrombosis of the portal venous system compared with one patient (1%) on placebo, the company said in a letter to healthcare professionals.
Avatar m tn perhaps it will be useful eric Helper T cell cytokine response to ribavirin priming before combined treatment with interferon alpha and ribavirin for patients with chronic hepatitis C Norihiro Furusyoa, b, , , Norihiko Kubob, Kazuhiro Toyodab, Hiroaki Takeokab, Shigeki Nabeshimaa, Masayuki Murataa, Makoto Nakamutac and Jun Hayashia, b aDepartment of General Medicine, Kyushu University Hospital, Higashi-Ku, Fukuoka 812-8582, Japan bDepartment of Environmental Medicine and Infectious Diseases,
Avatar n tn He was prescribed a treatment of ribavirin and pegintron. He was not monitored until the fourth week when he had spontaneous bleeding in his eyes and as a result has permanent eye damage. After reading about the medications on line it appears that he should have been monitored during the 1st week, 2nd and 4th weeks. Is this not the normal procedure for this type of treatment? If he had been monitored there would not have been the permanment damage to his vision.
1579934 tn?1431272511 I received my meds from Pegasys and am going in tomorrow for my 1st peginterferon alfa-2a injection. I'm questioning the dose for the ribavirin - the bottle says 3 tabs 2x daily which = 1200mg a day. Is that a normal dose? Should I bring up my concern to the nurse tomorrow? Also in the med guide it stated that ribavirin (copegus) can cause a drop in red blood cell count, should I be concerned that my platelets are below normal now? Is it likely to cause my platelets to drop anymore?
766573 tn?1365170066 [1] The retrospective sub-analysis of the Phase 3 REALIZE trial evaluated the impact of ribavirin dose reduction on SVR rates of previously treated genotype-1 chronic HCV patients who received treatment with telaprevir in combination with peginterferon alfa and ribavirin (T12PR48) or peginterferon alfa and ribavirin alone (PR).[1] Results were categorized according to patients' previous response to treatment.
Avatar f tn my mom is suffering from chronic hepatitis c and she was diagnosed by routine screening and there were no symptoms at that time, her PCR quantitative was done and the conts were 5,856,721 copies/ml she was started with simple interferon and ribavirin therapy for 6 months after which her PCR was repeated which came out as 68,000 copies/ml. after which she was adviced to continue treatment for further six months her counts turned out to be 274,200 copies/ml after six months.
Avatar n tn I am hep C from 1997 and I make 3 treatments with interferon and ribavirin, without rezults; now I have also hepatitis autoimune with antibody LKM 1, and my viremia persists I have thrombocytopenia and great bilirubinemia (only after the treatment nr. 3 - Pegasys + ribavirin 12 month) and powerfull dispneea (at each effort); I make water in organism. I don't have portal hipertension. I have easy splenomegalia, but not all the time. A dr. tell me that I have cirrosys.
446474 tn?1446351282 The drug was approved in November 2008 to treat low platelet counts -- idiopathic thrombocytopenia purpura -- in chronic sufferers who have had insufficient response to other drugs. However, eltrombopag should not be used to normalize platelet counts in hepatitis C patients, its manufacturer, GlaxoSmithKline (GSK), said Monday. It should only be used in patients with chronic hepatitis C whose condition prevents them from starting interferon therapy.
Avatar f tn Hi, I'm new to this site I would appreciate any information about marginal zone lymphoma (MZL) secondary to HepC infection? My partner was diagnosed with MZL in Jan 08 by surgical biopsy of a lymph node in his neck. It's a rare indolent form & most likely results from HepC infection. He has a small patch in the bone but CT scans & a PET scan revealed no other nodes in between, so is sort of stage 1 & 4 at the same time. He is 56yrs old, geno 1b, +ive for over 30 yrs.
4043517 tn?1374010173 Promacta (eltrombopag) has been available since 2008 for ITP and has used off label by some doctors to treat thrombocytopenia in treating low platelet counts in in hepatitis C patients doing interferon based treatment. The FDA has expanded its use now to include treating hepatitis C patients. NOTE: Safety and efficacy have not been established in combination with direct-acting antiviral agents approved for treatment of chronic hepatitis C genotype 1 infection.
1084115 tn?1385232189 Here is one reference paper... 'Thrombocytopenia Associated with Peginterferon/Ribavirin Therapy' http://www.clinicaloptions.com/Hepatitis/Annual%20Updates/2003%20Annual%20Update/Modules/ccohep2003_sulkowski/Pages/Page%209.aspx 'Interferon is associated with a rapid and sustained reduction in peripheral platelet count...bone marrow suppression, rather than increased platelet consumption, is the primary mechanism responsible for interferon-related thrombocytopenia.' '...
408795 tn?1324939275 Promacta is currently only OK'd for the treatment of ITP but it is used off label for people (like myself) whose platelets drop (thrombocytopenia) when on Interferon based therapy for Hep C.
1654058 tn?1407162666 Practical Strategies for the Management of Thrombocytopenia in HCV * Thrombocytopenia is common in advanced liver disease and can interfere with optimal treatment and management * Optimal treatment for thrombocytopenia management is currently unclear due to lack of data and safe and effective treatment * Platelet transfusions required for invasive procedures in cirrhotic patients with platelet counts < 50,000 cells/µL – If concurrent coagulopathy, prolonged prothrombin time, and/or prolong
Avatar f tn Hi, I'm new to this site I would appreciate any information about marginal zone lymphoma (MZL) secondary to HepC infection? My partner was diagnosed with MZL in Jan 08 by surgical biopsy of a lymph node in his neck. It's a rare indolent form & most likely results from HepC infection. He has a small patch in the bone but CT scans & a PET scan revealed no other nodes in between, so is sort of stage 1 & 4 at the same time. He is 56yrs old, geno 1b, +ive for over 30 yrs.
Avatar n tn Treatment with Incivek, peg-interferon and ribavirin reduces platelet counts. When you say low that is open to intuition. What numbers do you mean by high and low. There are different levels of low platelet counts. Depending on what the numbers are tells if their is need for concern. Platelets are produced in the bone marrow, the same as the red cells and most of the white blood cells. The average lifespan of a platelet is normally just 5 to 9 days.
Avatar f tn Safety and efficacy of recombinant human IL-11 (oprelvekin) in combination with interferon/ ribavirin in hepatitis C patients with thrombocytopenia. Hepatology. 2002;36(4 Pt 2):361A. 93. Lawitz EJ, Hepburn MJ, Casey TJ. A pilot study of interleukin-11 in subjects with chronic hepatitis C and advanced liver disease nonresponsive to antiviral therapy. Am J Gastroenterol. 2004;99:2359-2364. http://www.hcvadvocate.org/hcsp/articles/current_standards_2006.
1116669 tn?1269146866 Marc Bourlière, MD, Head of the Department of Hepatology and Gastroenterology with the Hospital Saint Joseph in Marseilles, France, and with the French National Agency for AIDS and Viral Hepatitis in Paris, stated several times that they are reluctant to lower the Ribavirin dosage in Cirrhotics due to the adverse effect it has on the SVR rates. He was quite adamant that Ribavirin dose reduction does, in fact, adversely affect SVR in Cirrhotic patients. Thanks for posting that link, Dennis.
244899 tn?1313628239 Interferon and Ribavirin, Pegasys and Ribavirin and again Interferon and Ribavirin before he decided to put me on the more powerful, and in my opinion, the more unpredictable Infergen...
Avatar f tn Hi, I'm new to this site I would appreciate any information about marginal zone lymphoma (MZL) secondary to HepC infection? My partner was diagnosed with MZL in Jan 08 by surgical biopsy of a lymph node in his neck. It's a rare indolent form & most likely results from HepC infection. He has a small patch in the bone but CT scans & a PET scan revealed no other nodes in between, so is sort of stage 1 & 4 at the same time. He is 56yrs old, geno 1b, +ive for over 30 yrs.
446474 tn?1446351282 The new once-daily oral medication PSI-7977 (Pharmasset), in combination with the standard regimen of pegylated interferon and ribavirin for patients infected with hepatitis C virus (HCV), cut the time for complete viral clearance in half, compared with interferon and ribavirin alone. In addition, the investigational agent was 100% effective in patients with the interleukin (IL)28B T/T mutation that has been associated with a poor response to interferon.
Avatar n tn Yes, Procrit works for hemolytic anemia, which is a common side effect of riba. What your doctor says may be technically correct but not very relevant to hep c treatment. There's "hemolysis" and there's ribavirin induced hemolytic anemica. Big difference. Procrit has made a big difference in my treatment. Take it, you'll like it.
Avatar m tn Ribavirin is a nucleoside analog. It comes as a pill, capsule or liquid. Ribavirin is taken twice daily, and dosing is based on weight. Although it is not effective against hepatitis C when used alone, ribavirin plays an important role in HCV combination treatment. Although scientists have not discovered exactly how it works, it is clear that adding ribavirin boosts cure rates and reduces the risk of relapse.
446474 tn?1446351282 The rates of sustained virologic response to pegylated interferon in combination with ribavirin ranged from 10% to 44% for HCV genotypes 1/4 to 33% to 72% for genotypes 2/3 in compensated cirrhosis.
Avatar f tn They are produced by cells in the bone marrow. Platelet counts often drop if you are on interferon and ribavirin therapy. This can put you at a higher risk for bleeding. If you have a low platelet count, you should pay particular attention to bleeding. Nosebleeds and bruises are more common. If you are concerned that you are bleeding or can't stop bleeding from a cut, seek medical attention.
244899 tn?1313628239 Low platelets (thrombocytopenia) can result in unexplained/ pronounced bruising, and shouldn’t be ignored. They also affect blood clotting. If it were me, I’d call my treating doctor and at least get this on record; he might want to review your previous labs.
Avatar n tn //www.docguide.com/news/content.nsf/PaperFrameSet?OpenForm&refid=2&id=7F4D5D923717CCD885256CD90024FEB2&c=&newsid=8525697700573E1885256F92002E8327&u=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15660393&ref=/news/content.nsf/SearchResults?openform&Query=ribavirin&so=date&id=7F4D5D923717CCD885256CD90024FEB2 http://www.docguide.com/news/content.nsf/PaperFrameSet?
Avatar f tn com/Hepatitis/Treatment%20Updates/Thrombocytopenia/Module/Thrombocytopenia%20in%20Hepatitis%20C/Pages/Page%201.aspx 'Thrombocytopenia, defined as a platelet count < 150,000 cells/µL, is a common hematologic abnormality in patients with chronic liver disease, including chronic hepatitis C virus (HCV) infection. The prevalence and severity of thrombocytopenia increase with hepatocellular damage.
Avatar f tn Three Rivers Pharmaceuticals, LLC), in combination with ribavirin, for retreatment of chronic hepatitis C (HCV) viral infection. The action was based on data from the United States–based Daily-Dose Consensus Interferon and Ribavirin: Efficacy of Combined Therapy clinical trial of nonresponders to prior pegylated interferon plus ribavirin therapy who were randomly assigned to receive active treatment or placebo for up to 48 weeks.
Avatar n tn A hematologist is not the type of doctor you should have managing your possible thrombocytopenia during treatment. They have no expertise with liver disease or hepatitis C treatment. Your main health problem is hepatitis C which has caused cirrhosis of the liver. Thrombocytopenia may not be the only issue you have and it is a complication of your cirrhosis. It is not a isolated condition.
3997096 tn?1349321461 IFN, by virtue of its bone marrow suppression effects, is known to cause thrombocytopenia, neutropenia and anemia. RBV can cause anaemia due to haemolysis as well as bone marrow suppression. Treatment-related cytopenias are more common with PEGIFN than standard IFN. Also, pre-existing cytopenias may preclude treatment with IFN. Neutropenia, while on treatment, may put the patient at risk for infections, which can be life-threatening at times.