Ribavirin teratogenicity

Common Questions and Answers about Ribavirin teratogenicity

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Avatar f tn I am sorry you are faced with this circumstance and hope things work out. I don't know what the chances are for your baby to be healthy. Ribavirin carries strong warnings against becoming pregnant during treatment and for 6 months after treatment. This warning applies to the female if she is on Ribavirin and it also applies to the female if her partner is on Ribavirin.
Avatar f tn If you read the Ribavirin Prescribing Information for ribavirin, right at the top of the label it says... Indications and Usage for Ribavirin 'The safety and efficacy of Ribavirin tablet therapy for the treatment of adenovirus, RSV, parainfluenza or influenza infections have not been established. Ribavirin tablets should not be used for these indications.
Avatar m tn Ribavirin therapy is contraindicated in women who are pregnant and in the male partners of women who are pregnant. Female patients receiving ribavirin and the partners of male patients receiving ribavirin must avoid pregnancy, using at least two reliable forms of contraception, during treatment and for 6 months after completion of treatment.
Avatar f tn Although current enrollment is far short of the required sample size, preliminary findings have not detected a signal indicating human teratogenicity for ribavirin. However, findings must be interpreted with caution concerning direct or indirect prenatal ribavirin exposures.
Avatar f tn Ribavirin Pregnancy Warnings Ribavirin has been assigned to pregnancy category X by the FDA. Nearly all animal studies have revealed evidence of embryolethality and teratogenicity. There are no controlled data in human pregnancies. One published case reports the uneventful use of ribavirin at 33 weeks gestation. Ribavirin therapy is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
Avatar f tn Most of the concerns raised about ribavirin's teratogenicty is a result of experimental animal tests. Ribavirin has been found to be teratogenic and/or embryolethal in several species of animals: in hamsters, ribavirin was associated with defects of the limbs, eyes, and brain; in rats, defects of the brain and eyes predominated -- but these were experiments exposing bone marrow cells.
Avatar f tn RISK OF SERIOUS DISORDERS AND RIBAVIRIN ASSOCIATED EFFECTS "Significant teratogenic and embryocidal effects have been demonstrated in all animal species exposed to ribavirin. Therefore, COPEGUS is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
4333925 tn?1359106042 Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to Ribavirin. In addition, Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months. Therefore, Ribavirin, including Ribavirin tablets, is contraindicated in women who are pregnant and in the male partners of women who are pregnant.
87972 tn?1322664839 I couldn't access the complete editorial, but the target 15 micro-mol/L ribavirin concentration was not arbitrary, but rather based on riba levels Lindahal and group had already observed was attainable by some subjects on normal ribavirin dosing. As you stated, this group has been doing ribavirin dosing research for many years and one of their findings is that serum ribavirin levels are based more on kidney function (and other factors, perhaps still unknown) as opposed to body weight.
Avatar n tn Adefovir is part of a class of drugs, nucleotide analogs, which are known to have mutagenic properties. Ribavirin, which is used in hepatitis C treatment is also in this class.