Ribavirin resistance

Common Questions and Answers about Ribavirin resistance


Avatar n tn No. The new STAT-C meds can be used in combination with SOC drugs (peginterferon & ribavirin) for those who previously failed SOC treatment and want to try again to achieve SVR. These patients will have a better chance of SVR with the new meds.
Avatar f tn I believe this is the insulin resistance test. Although there have been some rather recent studies that have associated insulin resistance with poor IFN response, it doesn’t preclude success either. I was *very* resistant to insulin throughout HCV therapy, and went on to SVR-land regardless. I don’t think I’d look for this to be a panacea for success is all… You probably don’t need to take any actions to remedy IR unless you believe you have metabolic issues.
26471 tn?1211940121 Metformin added to peginterferon alfa-2a/ribavirin regimen in genotype 1 HCV-infected patients with insulin resistance.... * Significantly improves insulin sensitivity. * Shows trend toward improved sustained virologic response (SVR) rates. * Ad hoc analysis found significant improvement in SVR rates for female patients only. Treating insulin resistance potential new goal for HCV therapy." Now they need to stop messing around and quit using suboptimal doses ...
Avatar m tn A single mutation associated with resistance has been reported at position 168 in the replicon system. A resistance mutation at this position has not been found during treatment with telaprevir and boceprevir. Therefore, ITMN-191 has the potential to be effective against HCV variants resistant to telaprevir and boceprevir. However, this hypothesis needs further evaluation in clinical trials.
Avatar f tn The very high sustained virologic rates (SVR) achieved in almost all populations treated with ledipasvir/sofosbuvir or ombitasvir/paritaprevir/ritonavir with dasabuvir (plus or minus ribavirin) might suggest that resistance testing is not necessary. However, new data presented at the recent European Association for the Study of the Liver (EASL) meeting in Vienna could suggest otherwise, at least for some patients.
353348 tn?1209699037 If you find any resistance, you might also put in a call to your Primary physician right away and maybe they can help. I'd also ask for a referral to another liver doctor -- preferably a liver specialist (hepatologist). Not to mince words, missing three or more consecutive days of ribavirin at this early point in treatment could seriously jepordize your chance of SVR. And missing one or two peg shots at this point, would put it in very serious jepordy.
2030686 tn?1351692148 because we take our riba pills withour protease inhibiotor pills, which have to be every 8 hrs, or we may develope a tolerance or resistance, to the third med we have to take, which we refer to as either "victrleis" or "incivek" (aka as boceprevir or teleprivir" I never had any side effects fromthe ribaviran pills, but I always made sure that I took them with a full meal, and they are absorbed better when eaten with some calories that include fat.
158241 tn?1237723123 Hepatic iron accumulation is associated with disease progression and resistance to interferon/ribavirin combination therapy in chronic hepatitis C. Background and Aims: Liver iron accumulation in patients with chronic hepatitis C (CHC) has received increasing attention in recent years.
26471 tn?1211940121 Peginterferon and Ribavirin Dosing and the Utility of Growth Factors Mitchell L. Shiffman, MD Effect of interferon dosing on virologic response It has long been recognized that the ability of interferon to reduce HCV RNA in serum is a dose-dependent process.
223152 tn?1346981971 That RVR is important and perhaps pre-dosing ribavirin gives one that edge. Talking about resistance also, if you can make the PR combo more effective early on and working with the PI at max then perhaps it increases the odds of hitting that RVR. Just tossing thoughts there. That's all theory and speculation based on, again, the time it takes to bring ribavirin to full concentration and the fact that interferon together with ribavirin at full dose is the most effective combo.
Avatar m tn mail order. I just noticed the label on the ribavirin bottle says to take 3 pills 2x daily. The incivek says to take 2 pills 3x daily, but in the instructions it says to take 7-9 hours apart. First question is, does everyone else take the riba 3 caps at a time twice a day? If I take riba twice a day, how far apart, and can I take it at the same time I take the incivek?
1815939 tn?1377995399 712-718. Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic hepatitis C patients. Dai CY, Huang JF, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, Chuang WL, Yu ML. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No.
Avatar n tn please would you describe if there is any relationship between IFN resistance and auto immune disease. in particular MC11 and lupus. if i remember right lupus is a disease already characterized by interferon sensitivity. if so is there any relationship in SVR and response with these and any precautions one should be aware of?
Avatar f tn HCV protease inhibitors when used with Peg-interferon/ribavirin have a 10-20% failure rate, and in these cases resistance mutations are detected about 95% of the time. Cross-resistance among current HCV PIs is widespread, " From the article Susie posted I found the above which may be of interest to you. Based on this you can say that from your boc failure you are 95% sure to have resistance mutations (some of which are known to be cross resistant with telaprevir).
Avatar f tn Based on their findings, they concluded that tizoxanide resistance can be generated in HCV replicon-containing cell lines, but that development of resistance to nitazoxanide or tizoxanide did not induce resistance to interferon or ribavirin. In fact, treatment of HCV replicon cells with tizoxanide heightened the antiviral effect of subsequent interferon treatment. They added that tizoxanide resistance is conferred by changes in the cell line, not by mutations in the HCV replicon.
Avatar m tn Drug resistance DOES NOT develop with interferon and ribavirin since these drugs do not specifically target the enzymes of the virus used in the viral replication process. http://www.hcvadvocate.org/hepatitis/Basics/New%20Antivirals_09.
Avatar f tn J Hepatol. 2009 Apr;50(4):712-718. Insulin resistance predicts response to peginterferon-alpha/ribavirin combination therapy in chronic hepatitis C patients. Dai CY, Huang JF, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, Chuang WL, Yu ML. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No.
Avatar f tn Still waiting for the results to Amanda's repeat 20 week VL, Prove 3, Group C, no-ribavirin...IF she has indeed experienced a breakthrough and I am able to convice them somehow to add Ribavirin at this point (triple therapy), do you think it will be too late? I know there has always been a lot of talk about Ribavirin working its best at the beginning of treatment...and that later on it is not as important...my point is, is the timing critical here?
493068 tn?1224768915 I completed the 48 weeksof Peg Interferon and Ribavirin Feb 2006 and have never been the same. I cleared the virus so far and feel very positive about this. I have never felt this sick and weak before the treatment. I have memory problems,weakness-fatigue, muscle and joint pain, headaches, severe facial and ocular Rosacea, depression panic attacks. I was very active before treatment going to yoga and work.
135456 tn?1301441224 The predosing of riba holds good theoretical merit, since the effective concentrations are not reached quickly with riba and also because "riba resistance" is not a likely quality that HCV could easily obtain.
13100769 tn?1445372717 I'm always searching for results from others with the same as me but I don't see much. I have 8 more weeks to go from a 24 week treatment of Ribavirin and Sovaldi. I'm praying for the best but could use some support. Thank you for reading.
Avatar n tn showed no difference in the SVR rate in patients with genotypes 2 and 3 infections using ribavirin doses ranging from 800 to 1,200 mg daily. Thus, the issue can be narrowed to optimizing therapy for genotype 1 patients." Speaking as a SVR-hungry Geno 1, I wonder if it would be the height of idiocy to increase my daily ribavirin dosage from 1000 mg to 1200 mg? I've been taking the lower amount, according to the current weight-based regime.
233616 tn?1312790796 In comparison with corresponding plasma values of ribavirin following a high-purine meal, Cmax, AUC0-144 and AUC0-∞ of ribavirin following a low-purine meal were 136% (90% confidence internal [CI]: 120%-155%), 134% (90% CI: 118%-153%), and 139% (90% CI: 120%-159%), respectively. This study indicates that dietary purines have an effect on ribavirin absorption. Dosage regimens of ribavirin might need to be adjusted according to the purine content of the meal.
568322 tn?1370169040 Study Results: PegIntron + Ribavirin........... RVR 6.1%......SVR 38.7% PegIntron+ Ribavirin+ Actos....RVR 27%.......SVR 60.4% Liver Int. 2009 Nov 16. Pioglitazone (Actos) improves virological response to peginterferon alpha-2b/ribavirin combination therapy in hepatitis C genotype 4 patients with insulin resistance. Khattab M, Emad M, Abdelaleem A, Eslam M, Atef R, Shaker Y, Hamdy L. Department of Internal Medicine, Minya University, Minya, Egypt.
Avatar m tn Aerobic exercise helps produce more mitochondria and a high-protein diet boosts the benefit of exercise, which decreases insulin resistance. Being insulin resistant impairs your ability to achieve a sustained response to Chemotherapy drugs peginterferon and ribavirin... Adding Metformin before and during Hep C treatment increases your odds of clearing... I found this website... http://www.hcvets.com/data/hcv_liver/InsulinResist.
446474 tn?1446351282 Viral Resistance and Remaining Challenges Cheers!
86664 tn?1291561395 Hello HR, If one took Alinia as monotherapy for 3 months and didn't clear do you suppose that a subsequent tx of Alinia/INF would be non effective since the virus may have developed a resistance to the first round of Alinia monotherapy? Is this correct reasoning?
7510956 tn?1411675017 My question to my doc was regarding Sovaldi. I did 12 weeks of Sovaldi plus peginteferon and ribavirin. I was UND, but relapsed by week 4 post. We plan to retreat in a couple of months with Ledipasvir/Sovaldi. Both drugs (sof and oly) probably create mutant strains that t are not very fit.
179856 tn?1333550962 Insulin resistance is the term used when the body needs more insulin than normal to control the blood sugar. Only when the pancreas can no longer produce sufficient insulin to overcome the resistance does diabetes occur, so TESTING THE BLOOD SUGAR ALONE WILL NOT BE ENOUGH TO ESTIMATE INSULIN RESISTANCE." "it is clear that INSULIN RESISTANCE IS UNDESIRABLE EVEN IF THE BLOOD SUGAR REMAINS RELATIVELY NORMAL (i.e. in the non-diabetic range).