Ribavirin pharmacokinetics

Common Questions and Answers about Ribavirin pharmacokinetics

rebetol

158241 tn?1237723123 A good paper about the pharmacokinetics of Ribavirin: http://tinyurl.com/35zu3n Fulltext pdf download Pharmacokinetics of ribavirin in patients with hepatitis C virus Janet R.
Avatar f tn 3 Pharmacokinetics The terminal half-life of ribavirin following administration of a single oral dose of ribavirin is about 120 to 170 hours. The total apparent clearance following administration of a single oral dose of ribavirin is about 26 L/h. There is extensive accumulation of ribavirin after multiple dosing (twice daily) such that the Cmax at steady state was four-fold higher than that of a single dose. http://kadmon.com/files/ribasphere-tablets-pi.
Avatar m tn http://en.wikipedia.org/wiki/Ribavirin Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters. Ribavirin is widely distributed in all tissues, including the CSF and brain.
3093770 tn?1389742726 00 am then again when I ate diner, I was in a ribavirin study and the study docs were ok with that schedule Pharmacokinetics Multiple dose Ribavirin pharmacokinetic data are available for HCV patients who received Ribavirin in combination with peginterferon alfa-2a. Following administration of 1200 mg/day with food for 12 weeks mean ± SD (n = 39; body weight > 75 kg) AUC0-12hr was 25,361 ± 7110 ng•hr/mL and Cmax was 2748 ± 818 ng/mL. The average time to reach Cmax was 2 hours.
Avatar m tn Everybody's response is individual, however this approach is based on what we know of the pharmacokinetics of ribavirin, it's steady state levels and it's synergistic relationship with INF. The risk to this is relatively low, seems to me - you've spent extra dollars for X weeks of ribavirin to have anywhere from limited to maximum effect when you take that first INF injection.
233616 tn?1312790796 The mechanism is unknown but may be related to better dissolution of ribavirin. Although the extent to which food affected ribavirin pharmacokinetics differed widely among studies, ribavirin has been recommended to be taken with food according to the manufacturers' package inserts. The human concentrative nucleoside transporter 2 (hCNT2, SLC28A2) is a member of the solute carrier 28 family.
Avatar f tn this is a link I got from hrsepwrguy .http://www.spfiles.com/pipeg-intron.pdf Effect of food on absorption of ribavirin: Both AUC and C-MAX increased by seventy percent when Rebetol Capsules were administered with a high fat meal: (841 kcal, 53.8 g fat, 31.6 g protein, and 57.4 g carbohydrate) in a single-dose pharmacokinetic study If you do the math you will have to eat 26.9 grams of fat with each dose for a 35% increase in absorbtion . He felt like this was too much fat to take in.
Avatar f tn If you have questions about what to do, call your healthcare provider. -------------------------------------------------------------------------------------------------- Pharmacokinetics Multiple dose Ribavirin pharmacokinetic data are available for HCV patients who received Ribavirin in combination with peginterferon alfa-2a.
Avatar m tn Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h. The type of meal also influenced the first-order input part of the absorption model (Table 1).
Avatar m tn the half life of ribavirin is 12 days - Multiple Dose; 120-170 hours - Single Dose. Ribavirin will also stay in your body for up to six months after tx because it is stored in your red blood cells and as the blood cells degrade it is was again released. The only reason we take two doses of ribavirin is because it can cause gastro issues for some.
7510956 tn?1411675017 Ribavirin has direct antiviral activity in tissue culture against many RNA viruses (such as HCV). Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
Avatar n tn org/article/S0016-5085(10)01584-2/abstract Telaprevir Is Effective Given Every 8 or 12 Hours With Ribavirin and Peginterferon Alfa-2a or -2b to Patients With Chronic Hepatitis C Gastroenterology Volume 140, Issue 2 , Pages 459-468.e1, February 2011 Patrick Marcellin, Xavier Forns, Tobias Goeser, Peter Ferenci, Frederik Nevens, Giampiero Carosi, Joost P.
1418633 tn?1314550345 Another forum member (bill1954) who I spoke with about why they separate the dose into twice daily suggested that it may be to minimize the GI issues that some people experience when taking riba. Pharmacokinetics Ribavirin is absorbed from the GI tract probably by nucleoside transporters. Absorption is about 45%, and this is modestly increased (to about 75%) by a fatty meal. Once in the plasma, ribavirin is transported through the cell membrane also by nucleoside transporters.
Avatar m tn Phase 1 OPTIMA Trial Finds Controlled-release Nitazoxanide Improves Response to Pegylated Interferon plus Ribavirin Researchers are studying a variety of approaches to improve response to interferon-based therapy for hepatitis C virus (HCV) infection. One agent under study, nitazoxanide, is a thiazolide anti-infective with activity against a variety of protozoa, bacteria, and viruses; it is currently FDA-approved for the treatment of Cryptosporidium and Giardia (under the brand name Alinia).
Avatar n tn For a chance to knock it out, I did Pegasys interferon and ribavirin in 2006-7. I dont have to tell you the sides effects were absolute hell. It has left me with some residual anxiety issues as well, anticipating the attacks I had on the treatment. My viral load got close to undetected on the interferon and riba. but then relapsed and I stopped at about 30 weeks. Fast forward to early 2013 when my (one of the best) liver dr let me know about ION-2 at my yearly appointment.
Avatar m tn Ribavirin is widely distributed in all tissues, including the CSF and brain. * Distributed to ALL tissues* The pharmacokinetics of ribavirin is dominated by trapping of the phosphated form inside cells, particularly red blood cells * Trapping it inside the Red Blood Cell* The volume of distribution of ribavirin is large (2000 L/kg) and the length of time the drug is trapped varies greatly from tissue to tissue.
Avatar n tn A Phase I Study of Chimeric Anti-Phosphatidylserine Monoclonal Antibody (Tarvacin™) in Patients Chronically Infected with Hepatitis C Virus (HCV) who are Non-responders or Relapsers after Treatment with Pegylated Interferon plus Ribavirin Contact Information Karen Roberts, MS 714.508.6035 ***@**** PHASE I STUDY SITE Bach & Godofsky, MD, PA, Bradenton, Florida, 34205, United States; Recruiting Mickey Mays, RNMS, ARNP 941-746-2711 Ext.
1253246 tn?1332076910 Both AUC and C-MAX increased by seventy percent when Rebetol Capsules were administered with a high fat meal: (841 kcal, 53.8 g fat, 31.6 g protein, and 57.4 g carbohydrate) in a single-dose pharmacokinetic study.
1084115 tn?1385232189 however, patients should be monitored for the signs and symptoms of increased narcotic effect. ------------------------------------------------------------------------------------------------------ 12.3 Pharmacokinetics Methadone The pharmacokinetics of concomitant administration of methadone and PegIntron were evaluated in 18 PegIntron-naïve chronic hepatitis C subjects receiving 1.5 mcg/kg PegIntron subcutaneously weekly.
732047 tn?1236014044 SAFETY, PHARMACOKINETICS, AND VIROLOGIC RESULTS FROM INFORM-1 Introduction: The combination of two potent direct-acting antivirals (DAAs), targeting two distinct viral enzymes, may offer advantages over single DAA strategies by enhancing potency, reducing the emergence of drug resistance, and possibly eliminating the need for PEG-IFN +/- ribavirin. The combination of R7128/R7227 offers the potential for a highly potent regimen with a high genetic barrier to resistance.
131114 tn?1380086790 The trial I am speaking of is not listed yet. It is with their polymerase + protease + ribavirin (only one arm has interferon). It's a Pharmasset+Tibotec study ......................................
Avatar m tn (1) improving the pharmacokinetics and side-effect profile of interferon; (2) improving the pharmacokinetics and side-effect profile of ribavirin; and (3) targeting viral enzymes required for HCV viral replication. This report discusses the most recent findings with regard to these new approaches to the treatment of HCV infection, with special focus on specifically targeted antiviral therapy for hepatitis C (STAT-C) regimens.
Avatar f tn I qualified my response with a reasoning based on the pharmacokinetics of interferon and the known synergistic relationship between interferon and ribavirin. It's more than the pharmacokinetics of ribavirin. It's the pharmacokinetics of interferon. There's a reason why interferon injections went from 3x a week to 1 time a week rather than every two weeks, etc.
897070 tn?1320656229 Ribavirin (RBV) Ribavirin (tablets) Arms, Groups and Cohorts in this Clinical Trial Experimental: Group A ABT-450/r, ABT-267, ABT-333, Ribavirin (RBV) in combination Experimental: Group B ABT-450/r and ABT-333, RBV in combination Experimental: Group C ABT-450/r, ABT-267, RBV in combination Experimental: Group D ABT-450/r, ABT-267, RBV in combination Experimental: Group E ABT-450/r, ABT-267, ABT-333 in combination Experimental: Group F ABT-450/r, ABT-267, ABT-333, RBV in combination Expe
Avatar m tn Although it makes sense to use such an assay to determine ribavirin pharmacokinetics, putting this method into practice in a clinical setting would be a challenge. Aside from the limitations of being able to access such an assay, the method would first have to be validated across multiple sites and in various patient populations—for example, according to race, body mass index, HCV genotype, and the presence or absence of renal failure—before becoming readily accepted.
Avatar m tn I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out. I'd query Schering-Plough as well as your hepatologist, if I were you. Please give me a heads-up if you solve the riddle.
5045042 tn?1365893700 Riba reaches it's peak concentration at about 2 hrs after taking Pharmacokinetics Multiple dose ribavirin pharmacokinetic data are available for HCV patients who received ribavirin in combination with peginterferon alfa-2a. Following administration of 1200 mg/day with food for 12 weeks mean±SD (n=39; body weight greater than 75 kg) AUC0-12hr was 25,361±7110 ng∙hr/mL and Cmax was 2748±818 ng/mL. The average time to reach Cmax was 2 hours. http://www.drugs.com/pro/copegus.
1476285 tn?1287341384 Hi I am curious if anyone has found a chart or info on how much interferon, ribavirin and telaprevir a person should take based on their weight. Maybe some of these are not even weight based altho it sure seems like a 100# person would not require as much of any of these as a 300# person but I don't know. If anyone has a link to this or a chart or any info, I'm just curious to know.
87972 tn?1322664839 Future studies should address the dosing, pharmacokinetics, and mechanism of action of ribavirin. The rationale for choosing a target concentration of 15 mol/L appeared to be arbitrary and not based on good pharmacokinetic and pharmacodynamic data. Lower plasma concentrations may have been as effective but it also raises the question as to whether ribavirin should continue to be administered based on body weight or dosed to achieve a target serum concentration.