Ribavirin monotherapy

Common Questions and Answers about Ribavirin monotherapy

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Avatar f tn Those meds go thru every organ you can think of including your kidneys. I can't think of any current tx that excludes the use of Ribavirin. Maybe you can get into a trial, whatever you decide I hope your doctor knows what he's doing. Also just to use the IFN doesn't work, here’s a link that is current. One last thing is I didn’t read that you’ve had a biopsy and what I did read says that your liver has minimal damage.
1815939 tn?1377995399 Yes both PSI 7977 and PSI 938 are both being tried as monotherapies. But it will be a long time before our trials are done dosing and have achieved SVR (6 months later). How are you doing Susie? Are you in Quantum?
979080 tn?1323437239 My doc thinks I have this for a long time ago (maybe 20 years) Being type 4 I am heavily considering giving Alinia monotherapy a shot (Gastroentereology March 2009 article) and eventually following it with standard treatment. Anybody in this forum that is type 4 and has experiences with Alina ? Is there a fibroscan available in NYC or close by ?
Avatar m tn Hi All, My treatment is in month 4 and the rash from the Ribavirin is giving me a run for my money. The itching and bumps have really started popping up all over. The Dr. has been very vague on what, if anything I can do. This is as bad or worse than poison ivy ever was. Has anyone had to deal with this side effect and are there any solutions.
Avatar f tn This was shown in a retrospective analysis of a large, randomized, placebo-controlled trial in which patients who achieved RVR had an SVR rate of approximately 90% regardless of whether they received peginterferon alfa and ribavirin, standard interferon and ribavirin, or peginterferon alfa monotherapy. In addition, the likelihood of SVR patients with genotype 1 infection who achieve an RVR does not appear to be affected by shortening the duration or reducing the dose of ribavirin.
Avatar m tn As a monotherapy it had a very low success rate. Pegalayted interferon was licensed in 2000-it is less harsh. If you were taking it daily you were probably on concensus interferon known as Infergen,generally considered the harshest regime. You have to factor in the effects of ribavirin which you probably did not take at that time. It is ,to quote a leading hepatologist, 'A filthy drug'. All in all you should find the current regime more tolerable than the daily shots.
Avatar m tn I was wondering any information you might have regarding svr and the ribavirin dose reduction (i did see a study regarding monotherapy with a viral load of less than 100,000 and genotype 2 here is the link http://www.ncbi.nlm.nih.gov/pubmed/19084937 any insight will be greatly appreciated.
Avatar m tn I began a 12 week treatment of Sovaldi /Ribavirin treatment for HCV 20 days ago. On the 17th day I developed a rash on my lower left leg. by the 18th day, my body was covered over 85% with the itchy red rash. I called the Sovaldi helpline and a nurse called me back. She said that they have not had any case reporting a rash on Sovaldi. I went to see my prescribing APRN and she saw the rash and had me stop the Ribavirin but continue Sovaldi.
223152 tn?1346981971 Fueloep and colleagues retrospectively analyzed the effect of ribavirin monotherapy followed by standard combination therapy (pegylated interferon plus ribavirin) on initial decline in HCV viral load and overall treatment outcomes. Addition of ribavirin reduces the risk of relapse after completing treatment, and therefore increases the likelihood of sustained virological response (SVR) to interferon-based therapy.
2030686 tn?1351692148 Keep this medication in the container it came in, tightly closed, and out of reach of children. Store ribavirin tablets and capsules at room temperature and away from excess heat and moisture (not in the bathroom). Store ribavirin oral solution in the refrigerator or at room temperature. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
Avatar f tn Last week blood test hemoglobin is at 8.7. My doctor just reduced Ribavirin from 1000mg daily to 800mg daily for the reason that my hemoglobin is going down. Blood work again in two weeks and he will see me after the blood test results. He told me he might stop the treatment is the hemoglobin continues to low. He will make that decision in the next visit after seen the results of the blood test he ordered.
Avatar m tn Riba is done for now and your b/f is on INF monotherapy until ribavirin resumes. A one week dosage reduction of ribavirin at this stage is considered manageable (although reduction is different than complete stoppage). I'd want to know how soon the doctor will resume ribavirin after the transfusion. Your boyfriend's RVR is in his favour. Good luck.
135456 tn?1301441224 I'll try and look into it later, but maybe you have a link? Ribavirin has been on the planet a long time as monotherapy for one thing or another, so I don't see any obvious red flags.
3140551 tn?1343255037 pdf Ribavirin monotherapy is not effective for the treatment of chronic hepatitis C virus infection and should not be used alone for this indication. http://www.drugs.com/pro/ribavirin.
Avatar m tn 25 Several studies have been conducted to evaluate ribavirin monotherapy in daily doses of 600-1,200 mg in the treatment of chronic hepatitis C.26-28 While all trials consistently showed a decrease in aminotransferase levels, no virologic end-of-treatment responses were observed. Moreover, the effect on aminotransferase levels was not maintained after the drug was discontinued. The antiviral mechanisms of ribavirin in patients with chronic hepatitis C are unknown.
Avatar f tn Anemia The primary toxicity of Ribavirin is hemolytic anemia, which was observed in approximately 13% of all Ribavirin/peginterferon alfa-2a- treated subjects in clinical trials. Anemia associated with Ribavirin occurs within 1 to 2 weeks of initiation of therapy. Because the initial drop in hemoglobin may be significant, it is advised that hemoglobin or hematocrit be obtained pretreatment and at week 2 and week 4 of therapy or more frequently if clinically indicated.
173930 tn?1196341998 Prediction of sustained virological response in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD) and ribavirin. Foster GR, Fried MW, Hadziyannis SJ, Messinger D, Freivogel K, Weiland O. The Royal London Hospital. London. UK. Objective. Patient- and virus-related factors influence the response of patients with chronic hepatitis C to interferon-based therapy.
Avatar m tn This is new research about boceprevir in treatment naive pacients with 2 and 3 genotypes,still unclear how it works, alone without SOC with peginterferon and ribavirin or with triple therapy after the initial boceprevir monotherapy.
Avatar n tn Pegasys is not used as a monotherapy in hep C patients. If he is taking it with ribavirin that would be for hepatitis C. People with pregnant partners should not use ribavirin during their partners pregnancy. Interferon alone is sometimes used for hairy cell leukemia, kidney cancer and melanoma. It is not used for liver damage as a monotherapy since it was proven that it does not help the liver recover from damage due to any reason.
Avatar m tn * PSI-7977 400mg QD with peginterferon and ribavirin for 12 weeks, followed by either PSI-7977 400mg QD monotherapy for 12 weeks or PSI-7977 400mg QD plus ribavirin for 12 weeks. HCV GT1 patients will be stratified by IL28B status and baseline HCV RNA to ensure balance across cohorts. An additional 25 treatment-naïve patients with HCV genotype 4, 5, 6 or indeterminate genotype, will receive PSI-7977 400mg QD with peginterferon and ribavirin for 24 weeks. ----- http://finance.yahoo.
Avatar n tn Mutation Rate of the Hepatitis C Virus NS5B in Patients Undergoing Treatment With Ribavirin Monotherapy. Lutchman G, Danehower S, Song BC, Liang TJ, Hoofnagle JH, Thomson M, Ghany MG. Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Background & Aims: Error catastrophe from an increase in mutation rate may be a possible mechanism of action of ribavirin in chronic hepatitis C (CHC).
Avatar m tn interferon monotherapy - interferon + ribavirin =13-15% interferon monotherapy - Peg +ribavirin = 25-40% Relapsers interferon monotherapy - Peg +ribavrin 32-50% "Previous Treatment With Inferior Therapy Many patients who have a nonresponse to treatment or who relapse following treatment may have been previously given standard interferon-based therapy. Peginterferon/ribavirin is more effective at achieving an SVR than treatment with standard interferon with or without ribavirin.
1084115 tn?1385232189 2012 Mode of action Hypotheses include: *ribovarin monophosphate inhibits inosine monophosphate dehydrogenase which results in decreased synthesis of guanosine triphosphate (GTP).
Avatar f tn I believe Zoogie did 73 weeks of monotherapy due to allergic reaction from ribavirin. Genotype 3 Hope the future drugs will give more promising results for those that can't take the ribavirin Zoogie. Enjoy everyday and keep an eye open for better treatment options.
Avatar m tn PEG-IFN-2a and ribavirin for 48 weeks (n=40), nitazoxanide monotherapy for 12 weeks, followed by nitazoxanide plus PEG-IFN -2a for 36 weeks (n=28), or nitazoxanide monotherapy for 12 weeks, followed by nitazoxanide plus PEG-IFN-2a and ribavirin for 36 weeks (n=28). , The percentages of patients with RVR and SVR were significantly higher in patients receiving triple therapy than in those receiving the standard of care (64 vs. 38%, P=0.048 and 79 vs. 50%, P=0.023 respectively).
Avatar m tn - what is the incidence of neutropenia due to ribavirin monotherapy? - what is the incidence of neutropenia due to SOC treatment? - how does interferon lower neutrophil counts? - how does ribavirin lower neutrophil counts? - what are appropriate steps in dealing with treatment neutropenia? I will start by setting what I think I know about the subject aside and go to my personal treatment history, but hope to follow up with some answers sourced in literature.
7510956 tn?1411675017 Ribavirin has direct antiviral activity in tissue culture against many RNA viruses (such as HCV). Ribavirin increases the mutation frequency in the genomes of several RNA viruses and ribavirin triphosphate inhibits HCV polymerase in a biochemical reaction.
Avatar m tn 7% in a meta-analysis of 14 trials with interferon monotherapy. After four years of follow up of treatment with interferon and ribavirin, late virological relapse rates of 3% (95% CI 1.4--4.6) and 1% (95% CI 0--2.0) have been reported for patients treated for 24 weeks and 48 weeks, respectively. After treatment with pegylated interferon with or without ribavirin, a late relapse rate of 0.8% was reported after four years of follow up.
149918 tn?1208132344 Sustained Response to Anti-Hepatitis C Virus Drugs Results in Cure in Virtually All Cases: Presented at EASL By Jill Stein BARCELONA, SPAIN -- April 16, 2007 -- More than 99% of patients infected with hepatitis C virus (HCV) who achieve a sustained virological response (SVR) have an outcome that may be considered a cure, according to data presented here at the 42nd Annual Meeting of the European Association for the Study of the Liver (EASL). Lead investigator Mark G.