In comparison with corresponding plasma values of ribavirin
following a high-purine meal, Cmax, AUC0-144 and AUC0-∞ of ribavirin
following a low-purine meal were 136% (90% confidence internal [CI]: 120%-155%), 134% (90% CI: 118%-153%), and 139% (90% CI: 120%-159%), respectively. This study indicates that dietary purines have an effect on ribavirin absorption. Dosage regimens of ribavirin might need to be adjusted according to the purine content of the meal.